Serum leptin and insulin concentrations in patients with insulinoma before and after surgery
Inferential studies suggest that circulating insulin concentrations positively regulate leptin secretion by adipocytes. In humans, however, insulin requires prolonged periods of time, and relatively artificial set-ups before a relationship with leptin can be observed. In the present work, serum lept...
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Veröffentlicht in: | European journal of endocrinology 1998-01, Vol.138 (1), p.86-88 |
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creator | Popovic, V Micic, D Danjanovic, S Zoric, S Djurovic, M Obradovic, S Petakov, M Dieguez, C Casanueva, FF |
description | Inferential studies suggest that circulating insulin concentrations positively regulate leptin secretion by adipocytes. In humans, however, insulin requires prolonged periods of time, and relatively artificial set-ups before a relationship with leptin can be observed. In the present work, serum leptin concentrations were measured in five patients with insulinoma before and one month after surgery and in five control subjects matched by sex and body mass index (BMI). The control subjects presented a mean serum leptin concentration of 6.7+/-1.5 microg/l and a BMI of 24.9+/-1.1. The mean serum leptin concentration in patients with insulinoma was 11.8+/-3.1 microg/l (P < 0.05 vs controls), with a BMI of 26.3+/-1.9. After surgery, there was a non-significant reduction in BMI (25.8+/-1.7), and a clear reduction in serum leptin concentration (5.6+/-2.4 microg/l, P < 0.05 vs pre surgical values and no difference vs control subjects). The fasting area under the curve (AUC) of insulin concentration (in mU/l per 120 min) before surgery was 14421+/-4981 and after surgery was 1306-/+171 (P < 0.05). Before surgery, serum leptin concentrations significantly correlated with BMI (r = 0.71) and AUC of insulin (r = 0.82), a correlation that was lost after surgery. In conclusion, serum leptin concentrations are significantly elevated in patients with chronically high insulin levels due to insulinoma. After surgical treatment and normalization of insulin values, leptin levels return to normal. |
doi_str_mv | 10.1530/eje.0.1380086 |
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In humans, however, insulin requires prolonged periods of time, and relatively artificial set-ups before a relationship with leptin can be observed. In the present work, serum leptin concentrations were measured in five patients with insulinoma before and one month after surgery and in five control subjects matched by sex and body mass index (BMI). The control subjects presented a mean serum leptin concentration of 6.7+/-1.5 microg/l and a BMI of 24.9+/-1.1. The mean serum leptin concentration in patients with insulinoma was 11.8+/-3.1 microg/l (P < 0.05 vs controls), with a BMI of 26.3+/-1.9. After surgery, there was a non-significant reduction in BMI (25.8+/-1.7), and a clear reduction in serum leptin concentration (5.6+/-2.4 microg/l, P < 0.05 vs pre surgical values and no difference vs control subjects). The fasting area under the curve (AUC) of insulin concentration (in mU/l per 120 min) before surgery was 14421+/-4981 and after surgery was 1306-/+171 (P < 0.05). Before surgery, serum leptin concentrations significantly correlated with BMI (r = 0.71) and AUC of insulin (r = 0.82), a correlation that was lost after surgery. In conclusion, serum leptin concentrations are significantly elevated in patients with chronically high insulin levels due to insulinoma. After surgical treatment and normalization of insulin values, leptin levels return to normal.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/eje.0.1380086</identifier><identifier>PMID: 9461322</identifier><language>eng</language><publisher>Colchester: European Society of Endocrinology</publisher><subject>Adult ; Biological and medical sciences ; Body Mass Index ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Fasting ; Female ; Humans ; Insulin - blood ; Insulinoma - blood ; Insulinoma - pathology ; Insulinoma - surgery ; Leptin ; Male ; Medical sciences ; Middle Aged ; Osmolar Concentration ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Postoperative Period ; Proteins - analysis ; Reference Values ; Tumors. Hypoglycemia</subject><ispartof>European journal of endocrinology, 1998-01, Vol.138 (1), p.86-88</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b409t-8a33693fc2ae49e6cd620be91207b2968b89211d406d0e945ab63ef920b606a43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2125114$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9461322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Popovic, V</creatorcontrib><creatorcontrib>Micic, D</creatorcontrib><creatorcontrib>Danjanovic, S</creatorcontrib><creatorcontrib>Zoric, S</creatorcontrib><creatorcontrib>Djurovic, M</creatorcontrib><creatorcontrib>Obradovic, S</creatorcontrib><creatorcontrib>Petakov, M</creatorcontrib><creatorcontrib>Dieguez, C</creatorcontrib><creatorcontrib>Casanueva, FF</creatorcontrib><title>Serum leptin and insulin concentrations in patients with insulinoma before and after surgery</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>Inferential studies suggest that circulating insulin concentrations positively regulate leptin secretion by adipocytes. In humans, however, insulin requires prolonged periods of time, and relatively artificial set-ups before a relationship with leptin can be observed. In the present work, serum leptin concentrations were measured in five patients with insulinoma before and one month after surgery and in five control subjects matched by sex and body mass index (BMI). The control subjects presented a mean serum leptin concentration of 6.7+/-1.5 microg/l and a BMI of 24.9+/-1.1. The mean serum leptin concentration in patients with insulinoma was 11.8+/-3.1 microg/l (P < 0.05 vs controls), with a BMI of 26.3+/-1.9. After surgery, there was a non-significant reduction in BMI (25.8+/-1.7), and a clear reduction in serum leptin concentration (5.6+/-2.4 microg/l, P < 0.05 vs pre surgical values and no difference vs control subjects). The fasting area under the curve (AUC) of insulin concentration (in mU/l per 120 min) before surgery was 14421+/-4981 and after surgery was 1306-/+171 (P < 0.05). Before surgery, serum leptin concentrations significantly correlated with BMI (r = 0.71) and AUC of insulin (r = 0.82), a correlation that was lost after surgery. In conclusion, serum leptin concentrations are significantly elevated in patients with chronically high insulin levels due to insulinoma. After surgical treatment and normalization of insulin values, leptin levels return to normal.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Fasting</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulinoma - blood</subject><subject>Insulinoma - pathology</subject><subject>Insulinoma - surgery</subject><subject>Leptin</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osmolar Concentration</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Postoperative Period</subject><subject>Proteins - analysis</subject><subject>Reference Values</subject><subject>Tumors. Hypoglycemia</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtLxDAQh4Mo67p69Cj0IN665tU0OYr4ggUPKngQSpJONUsfa9Ii-9-btXVP82Pmm0n4EDoneEkyhq9hDcsYmcRYigM0JzxXqZDs_RDNscQ85YKzY3QSwhpjEjOeoZnigjBK5-jjBfzQJDVsetcmui0T14ahjtl2rYW297p3XRtiO9nEGDsh-XH91z_XNToxUHUe_rZ11YNPwuA_wW9P0VGl6wBnU12gt_u719vHdPX88HR7s0oNx6pPpWZMKFZZqoErELYUFBtQhOLcUCWkkYoSUnIsSgyKZ9oIBpWKkMBCc7ZAV-Pdje--Bwh90bhgoa51C90QilyJXGWSRTAdQeu7EDxUxca7RvttQXCxs1lEm0WMo83IX0yHB9NAuacnfXF-Oc11sLquvG6tC3uMEpoRsvtfMmLGdcHuHLrKWb3n4ku_YkyJkQ</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Popovic, V</creator><creator>Micic, D</creator><creator>Danjanovic, S</creator><creator>Zoric, S</creator><creator>Djurovic, M</creator><creator>Obradovic, S</creator><creator>Petakov, M</creator><creator>Dieguez, C</creator><creator>Casanueva, FF</creator><general>European Society of Endocrinology</general><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980101</creationdate><title>Serum leptin and insulin concentrations in patients with insulinoma before and after surgery</title><author>Popovic, V ; Micic, D ; Danjanovic, S ; Zoric, S ; Djurovic, M ; Obradovic, S ; Petakov, M ; Dieguez, C ; Casanueva, FF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b409t-8a33693fc2ae49e6cd620be91207b2968b89211d406d0e945ab63ef920b606a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Fasting</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulinoma - blood</topic><topic>Insulinoma - pathology</topic><topic>Insulinoma - surgery</topic><topic>Leptin</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osmolar Concentration</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Postoperative Period</topic><topic>Proteins - analysis</topic><topic>Reference Values</topic><topic>Tumors. Hypoglycemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Popovic, V</creatorcontrib><creatorcontrib>Micic, D</creatorcontrib><creatorcontrib>Danjanovic, S</creatorcontrib><creatorcontrib>Zoric, S</creatorcontrib><creatorcontrib>Djurovic, M</creatorcontrib><creatorcontrib>Obradovic, S</creatorcontrib><creatorcontrib>Petakov, M</creatorcontrib><creatorcontrib>Dieguez, C</creatorcontrib><creatorcontrib>Casanueva, FF</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Popovic, V</au><au>Micic, D</au><au>Danjanovic, S</au><au>Zoric, S</au><au>Djurovic, M</au><au>Obradovic, S</au><au>Petakov, M</au><au>Dieguez, C</au><au>Casanueva, FF</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum leptin and insulin concentrations in patients with insulinoma before and after surgery</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>138</volume><issue>1</issue><spage>86</spage><epage>88</epage><pages>86-88</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>Inferential studies suggest that circulating insulin concentrations positively regulate leptin secretion by adipocytes. In humans, however, insulin requires prolonged periods of time, and relatively artificial set-ups before a relationship with leptin can be observed. In the present work, serum leptin concentrations were measured in five patients with insulinoma before and one month after surgery and in five control subjects matched by sex and body mass index (BMI). The control subjects presented a mean serum leptin concentration of 6.7+/-1.5 microg/l and a BMI of 24.9+/-1.1. The mean serum leptin concentration in patients with insulinoma was 11.8+/-3.1 microg/l (P < 0.05 vs controls), with a BMI of 26.3+/-1.9. After surgery, there was a non-significant reduction in BMI (25.8+/-1.7), and a clear reduction in serum leptin concentration (5.6+/-2.4 microg/l, P < 0.05 vs pre surgical values and no difference vs control subjects). The fasting area under the curve (AUC) of insulin concentration (in mU/l per 120 min) before surgery was 14421+/-4981 and after surgery was 1306-/+171 (P < 0.05). Before surgery, serum leptin concentrations significantly correlated with BMI (r = 0.71) and AUC of insulin (r = 0.82), a correlation that was lost after surgery. In conclusion, serum leptin concentrations are significantly elevated in patients with chronically high insulin levels due to insulinoma. After surgical treatment and normalization of insulin values, leptin levels return to normal.</abstract><cop>Colchester</cop><pub>European Society of Endocrinology</pub><pmid>9461322</pmid><doi>10.1530/eje.0.1380086</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Biological and medical sciences Body Mass Index Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fasting Female Humans Insulin - blood Insulinoma - blood Insulinoma - pathology Insulinoma - surgery Leptin Male Medical sciences Middle Aged Osmolar Concentration Pancreatic Neoplasms - blood Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Postoperative Period Proteins - analysis Reference Values Tumors. Hypoglycemia |
title | Serum leptin and insulin concentrations in patients with insulinoma before and after surgery |
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