Actions of pinacidil on membrane currents in canine ventricular myocytes and their modulation by intracellular ATP and cAMP

We studied the effects of pinacidil (3-50 microM) on the membrane currents of canine ventricular myocytes, using the whole-cell variant of the patch-clamp technique, and the modulation of these effects by intracellular environment, using the pipette perfusion technique. The following observations we...

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Veröffentlicht in:	Pflügers Archiv 1990, Vol.415 (4), p.414-424
Hauptverfasser:	GEA-NY TSENG, HOFFMAN, B. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - physiology Animals Antihypertensive agents Biological and medical sciences Cardiovascular system Cyclic AMP - physiology Dogs Guanidines - pharmacology Heart - drug effects Heart - physiology Heart Ventricles In Vitro Techniques Medical sciences Membrane Potentials - drug effects Myocardium - cytology Pharmacology. Drug treatments Pinacidil Potassium Channels - physiology Vasodilator Agents - pharmacology
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