Galactocerebroside and not glucocerebroside or ceramide stimulate epidermal β-glucocerebrosidase activity

Glycosphingolipids including glucocerebroside (GluCer) and galactocerebroside (GalCer) have been recognized as bioreguratory lipids by our group and others. In addition, our recent study demonstrated that GalCer corrects dry skin conditions in humans. The processing of stratum corneum lipids, which...

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Veröffentlicht in:	Journal of dermatological science 1998, Vol.16 (2), p.111-119
Hauptverfasser:	Hara, Mariko, Uchida, Yoshikazu, Haratake, Akinori, Mimura, Kunio, Hamanaka, Sumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylceramide Animals Ceramide Ceramides - pharmacology Enzyme Activation - drug effects Galactocerebroside Galactosylceramides - analysis Galactosylceramides - pharmacology Glucocerebroside Glucosylceramidase - drug effects Glucosylceramidase - metabolism Glucosylceramides - pharmacology Glycosphingolipids - metabolism Humans Male Mice Mice, Hairless Sensitivity and Specificity Skin - chemistry Skin - enzymology Sphingolipids - pharmacology β-glucocerebrosidase
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