Pharmacokinetics and pharmacodynamics of terfenadine and chlorpheniramine in the elderly

In a double-blind, randomized, crossover study, the H 1-receptor antagonists, terfenadine and chlorpheniramine, were investigated in eight healthy, fasting female subjects, aged 67.8 ± SD 0.8 years, who ingested single doses of terfenadine, 1 mg/kg (mean dose, 69.6 ± 11.2 mg), and chlorpheniramine,...

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