Prospective association between lipid soluble antioxidants and coronary heart disease in men : The Multiple Risk Factor intervention Trial
A nested case-control study was performed using participants enrolled in the Multiple Risk Factor Intervention Trial (MRFIT). The cases involved nonfatal myocardial infarction or death from coronary heart disease. Serum samples (n = 734) obtained at baseline and frozen for approximately 20 years wer...
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| Veröffentlicht in: | American journal of epidemiology 1998-01, Vol.147 (2), p.180-186 |
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| creator | EVANS, R. W SHATEN, B. J DAY, B. W KULLER, L. H |
| description | A nested case-control study was performed using participants enrolled in the Multiple Risk Factor Intervention Trial (MRFIT). The cases involved nonfatal myocardial infarction or death from coronary heart disease. Serum samples (n = 734) obtained at baseline and frozen for approximately 20 years were analyzed for the antioxidants, carotenoids, retinol, and alpha-, gamma-, and total tocopherol. The concentrations of antioxidants were in the expected range and their association with low density lipoprotein (LDL) cholesterol reflected their absorption and transport mechanisms. Among nonsmokers, the odds ratios (95% confidence intervals (CI)) for quartile IV versus quartile I were 1.40 (0.40-4.89), 0.77 (0.20-2.96), 1.45 (0.38-5.56), 2.34 (0.56-9.81), and 2.40 (0.52-11.07) for retinol, total carotenoids, and alpha-, gamma-, and total tocopherol, respectively. The equivalent odds ratios (95% CI) for smokers were 0.90 (0.34-2.41), 0.66 (0.23-1.84), 0.67 (0.21-2.13), 2.04 (0.88-4.73), and 0.52 (0.16-1.67), respectively. This analysis of antioxidant concentrations by quartiles indicated no significant association of antioxidant levels with the risk of coronary disease death or nonfatal myocardial infarction. |
| doi_str_mv | 10.1093/oxfordjournals.aje.a009432 |
| format | Article |
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Among nonsmokers, the odds ratios (95% confidence intervals (CI)) for quartile IV versus quartile I were 1.40 (0.40-4.89), 0.77 (0.20-2.96), 1.45 (0.38-5.56), 2.34 (0.56-9.81), and 2.40 (0.52-11.07) for retinol, total carotenoids, and alpha-, gamma-, and total tocopherol, respectively. The equivalent odds ratios (95% CI) for smokers were 0.90 (0.34-2.41), 0.66 (0.23-1.84), 0.67 (0.21-2.13), 2.04 (0.88-4.73), and 0.52 (0.16-1.67), respectively. This analysis of antioxidant concentrations by quartiles indicated no significant association of antioxidant levels with the risk of coronary disease death or nonfatal myocardial infarction.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/oxfordjournals.aje.a009432</identifier><identifier>PMID: 9457009</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Antioxidants - analysis ; Biological and medical sciences ; Cardiology. 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W</creatorcontrib><creatorcontrib>SHATEN, B. J</creatorcontrib><creatorcontrib>DAY, B. W</creatorcontrib><creatorcontrib>KULLER, L. H</creatorcontrib><title>Prospective association between lipid soluble antioxidants and coronary heart disease in men : The Multiple Risk Factor intervention Trial</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>A nested case-control study was performed using participants enrolled in the Multiple Risk Factor Intervention Trial (MRFIT). The cases involved nonfatal myocardial infarction or death from coronary heart disease. Serum samples (n = 734) obtained at baseline and frozen for approximately 20 years were analyzed for the antioxidants, carotenoids, retinol, and alpha-, gamma-, and total tocopherol. The concentrations of antioxidants were in the expected range and their association with low density lipoprotein (LDL) cholesterol reflected their absorption and transport mechanisms. Among nonsmokers, the odds ratios (95% confidence intervals (CI)) for quartile IV versus quartile I were 1.40 (0.40-4.89), 0.77 (0.20-2.96), 1.45 (0.38-5.56), 2.34 (0.56-9.81), and 2.40 (0.52-11.07) for retinol, total carotenoids, and alpha-, gamma-, and total tocopherol, respectively. The equivalent odds ratios (95% CI) for smokers were 0.90 (0.34-2.41), 0.66 (0.23-1.84), 0.67 (0.21-2.13), 2.04 (0.88-4.73), and 0.52 (0.16-1.67), respectively. This analysis of antioxidant concentrations by quartiles indicated no significant association of antioxidant levels with the risk of coronary disease death or nonfatal myocardial infarction.</description><subject>Adult</subject><subject>Antioxidants - analysis</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Carotenoids - blood</subject><subject>Cohort Studies</subject><subject>Coronary Disease - blood</subject><subject>Coronary heart disease</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Prospective Studies</subject><subject>Statistical Distributions</subject><subject>Vitamin A - blood</subject><subject>Vitamin E - blood</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd9qFTEQxoMo9bT6CEIQ8W6P-bfZk95Jaa1QUeR4vcwmszTHnM2aZGt9BZ_aaJeCV8Pw_b4ZZj5CXnO25czId_F-jMkd4pImCHkLB9wCY0ZJ8YRsuOp0o0Wrn5INY0w0RmjxnJzmfGCMc9OyE3JiVNtVx4b8_pJintEWf4cUco7WQ_FxogOWn4gTDX72juYYliFUYqrivXe15to4amOKE6Rf9BYhFep8RshI_USP1XxO97dIPy2h-Lm6v_r8nV6BLTFVomC6w-nfsn3yEF6QZ2M9B1-u9Yx8u7rcX1w3N58_fLx4f9NYpXlppBkMjhwZdArGVrZaD7Id1Y45jS0aqNio2E5pMzgUrRrQ6R3oTkitdh3KM_L2Ye6c4o8Fc-mPPlsMASaMS-47U1nOZQXPH0Bbf5QTjv2c_LEe23PW_w2i_z-IvgbRr0FU86t1yzIc0T1a189X_c2qQ7YQxgST9fkRE1wJI4T8A9dsmuY</recordid><startdate>19980115</startdate><enddate>19980115</enddate><creator>EVANS, R. W</creator><creator>SHATEN, B. J</creator><creator>DAY, B. W</creator><creator>KULLER, L. H</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980115</creationdate><title>Prospective association between lipid soluble antioxidants and coronary heart disease in men : The Multiple Risk Factor intervention Trial</title><author>EVANS, R. W ; SHATEN, B. J ; DAY, B. W ; KULLER, L. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-39b9ef1e0a74af53566b35f480d6e5e9ac46f408469bde254bed68a67236487e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Antioxidants - analysis</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Carotenoids - blood</topic><topic>Cohort Studies</topic><topic>Coronary Disease - blood</topic><topic>Coronary heart disease</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Prospective Studies</topic><topic>Statistical Distributions</topic><topic>Vitamin A - blood</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EVANS, R. W</creatorcontrib><creatorcontrib>SHATEN, B. J</creatorcontrib><creatorcontrib>DAY, B. W</creatorcontrib><creatorcontrib>KULLER, L. 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H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective association between lipid soluble antioxidants and coronary heart disease in men : The Multiple Risk Factor intervention Trial</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>1998-01-15</date><risdate>1998</risdate><volume>147</volume><issue>2</issue><spage>180</spage><epage>186</epage><pages>180-186</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>A nested case-control study was performed using participants enrolled in the Multiple Risk Factor Intervention Trial (MRFIT). The cases involved nonfatal myocardial infarction or death from coronary heart disease. Serum samples (n = 734) obtained at baseline and frozen for approximately 20 years were analyzed for the antioxidants, carotenoids, retinol, and alpha-, gamma-, and total tocopherol. The concentrations of antioxidants were in the expected range and their association with low density lipoprotein (LDL) cholesterol reflected their absorption and transport mechanisms. Among nonsmokers, the odds ratios (95% confidence intervals (CI)) for quartile IV versus quartile I were 1.40 (0.40-4.89), 0.77 (0.20-2.96), 1.45 (0.38-5.56), 2.34 (0.56-9.81), and 2.40 (0.52-11.07) for retinol, total carotenoids, and alpha-, gamma-, and total tocopherol, respectively. The equivalent odds ratios (95% CI) for smokers were 0.90 (0.34-2.41), 0.66 (0.23-1.84), 0.67 (0.21-2.13), 2.04 (0.88-4.73), and 0.52 (0.16-1.67), respectively. This analysis of antioxidant concentrations by quartiles indicated no significant association of antioxidant levels with the risk of coronary disease death or nonfatal myocardial infarction.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>9457009</pmid><doi>10.1093/oxfordjournals.aje.a009432</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Antioxidants - analysis Biological and medical sciences Cardiology. Vascular system Carotenoids - blood Cohort Studies Coronary Disease - blood Coronary heart disease Heart Humans Male Medical sciences Middle Aged Myocardial Infarction - blood Prospective Studies Statistical Distributions Vitamin A - blood Vitamin E - blood |
| title | Prospective association between lipid soluble antioxidants and coronary heart disease in men : The Multiple Risk Factor intervention Trial |
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