Soluble Penicillin-Binding Protein 2a: β-Lactam Binding and Inhibition by Non-β-Lactams Using a 96-Well Format

High level methicillin resistance inStaphylococcus aureusis dependent upon the acquisition of themecAgene encoding penicillin-binding protein 2a (PBP2a). PBP2a is a member of a family of peptidoglycan biosynthetic enzymes involved in assembly of the cell wall in bacteria and is poorly inactivated by...

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Veröffentlicht in:	Analytical biochemistry 1998-01, Vol.255 (1), p.113-119
Hauptverfasser:	Toney, Jeffrey H., Hammond, Gail G., Leiting, Barbara, Pryor, KellyAnn D., Wu, Joseph K., Cuca, Gregory C., Pompliano, David L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Bacterial Proteins Binding Sites Binding, Competitive Biotechnology - instrumentation Biotechnology - methods Carbapenems - chemistry Carbapenems - metabolism Carrier Proteins - antagonists & inhibitors Carrier Proteins - chemistry Carrier Proteins - metabolism Chemical Precipitation Dimethyl Sulfoxide Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Hexosyltransferases Imidazoles - chemistry Imidazoles - metabolism Imipenem - chemistry Imipenem - metabolism Kinetics Methods Micropore Filters Muramoylpentapeptide Carboxypeptidase - antagonists & inhibitors Muramoylpentapeptide Carboxypeptidase - chemistry Muramoylpentapeptide Carboxypeptidase - metabolism Penicillin G - chemistry Penicillin G - metabolism Penicillin-Binding Proteins Peptidyl Transferases Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sensitivity and Specificity Solubility Triazines - chemistry Triazines - metabolism Triazines - pharmacology Tritium
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