Role of Ceruloplasmin in Cellular Iron Uptake

Individuals with hereditary ceruloplasmin (Cp) deficiency have profound iron accumulation in most tissues, which suggests that Cp is important for normal release of cellular iron. Here, in contrast to expectations, Cp was shown to increase iron uptake by HepG2 cells, increasing the apparent affinity...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-01, Vol.279 (5351), p.714-717
Hauptverfasser:	Mukhopadhyay, Chinmay K., Attieh, Zouhair K., Fox, Paul L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biological and medical sciences Biological Transport Cell metabolism Cell physiology Cellular biology Ceruloplasmin - biosynthesis Ceruloplasmin - genetics Ceruloplasmin - pharmacology Ceruloplasmin - physiology Chlorides Complementary DNA Culture Media, Conditioned Ferric Compounds - pharmacology Fundamental and applied biological sciences. Psychology Hep G2 cells Hepatocytes Homeostasis Humans Iron Iron (Nutrient) Iron - metabolism Iron Chelating Agents - pharmacology Iron in the body Liver - metabolism Membrane and intracellular transports Messenger RNA Molecular and cellular biology Observations Oxidases Patients Physiological aspects Physiological regulation RNA RNA, Messenger - genetics RNA, Messenger - metabolism Space life sciences Transcription, Genetic Transferrin - metabolism Transferrins Tumor Cells, Cultured Yeasts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!