Two cytochromes P450 are major hepatocellular autoantigens in autoimmune polyglandular syndrome type 1

Background & Aims: Liver disease has been described in 10%–15% of patients with autoimmune polyglandular syndrome type 1 (APS-1). After the discovery of cytochrome P450 1A2 (CYP1A2) as a hepatocellular autoantigen in liver-kidney microsomal autoantibody (LKM)-positive patients with APS-1, the in...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1998-02, Vol.114 (2), p.324-328
Hauptverfasser:	Clemente, Maria Grazia, Meloni, Antonella, Obermayer-Straub, Petra, Frau, Fulvia, Manns, Michael Peter, de Virgiliis, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aryl Hydrocarbon Hydroxylases Autoantibodies - analysis Autoantibodies - immunology Autoantigens - analysis Autoantigens - immunology Biological and medical sciences Blotting, Western Cytochrome P-450 CYP1A2 - analysis Cytochrome P-450 CYP1A2 - immunology Cytochrome P-450 CYP2A6 Cytochrome P-450 Enzyme System - analysis Cytochrome P-450 Enzyme System - immunology Female Fluorescent Antibody Technique, Indirect Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mixed Function Oxygenases - analysis Mixed Function Oxygenases - immunology Other diseases. Semiology Pedigree Polyendocrinopathies, Autoimmune - genetics Polyendocrinopathies, Autoimmune - immunology
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