Immunoreactivity affects the biodistribution and tumor targeting of radiolabeled anti-P97 Fab fragment

Hydroxylapatite high performance liquid chromatography was used to prepare two fractions from 125I- Fab 96.5. One fraction (peak 1) had relatively low immunoreactivity (25-38%) and the second fraction (peak 2) had high immunoreactivity (70-81%). Scatchard analysis showed similar affinity constants f...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 1990-02, Vol.31 (2), p.202-210
Hauptverfasser:	YOKOYAMA, K, REYNOLDS, J. C, PAIK, C. H, SOOD, V. K, MALONEY, P. J, LARSON, S. M, REBA, R. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacokinetics Antigens, Neoplasm Biological and medical sciences Experimental skin tumors Female Immunoglobulin Fab Fragments - immunology Immunoglobulin Fab Fragments - pharmacokinetics Immunoglobulin Fragments - immunology Immunoglobulin Fragments - pharmacokinetics In Vitro Techniques Iodine Radioisotopes Medical sciences Melanoma - diagnostic imaging Melanoma - metabolism Melanoma-Specific Antigens Mice Mice, Inbred BALB C Mice, Nude Neoplasm Proteins - immunology Neoplasm Transplantation Radionuclide Imaging Tissue Distribution Transplantation, Heterologous Tumors
Online-Zugang:	Volltext
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