Characterization of DNA-Binding Proteins Required for Glucocorticoid Induction of CYP3A23

Cytochrome P450 (CYP) 3A23 is transcriptionally regulated in rat liver by such glucocorticoids as dexamethasone (DEX) and by such antiglucocorticoids as pregnenolone 16α-carbonitrile (PCN). Based on studies of CYP3A23 gene fragments expressed in primary cultures of adult rat hepatocytes and tested f...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1998-01, Vol.349 (2), p.251-260
Hauptverfasser:	Quattrochi, Linda C., Yockey, Charles B., Barwick, Joyce L., Guzelian, Philip S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases Base Sequence Cells, Cultured Chloramphenicol O-Acetyltransferase - biosynthesis CYP3A23 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics dexamethasone Dexamethasone - pharmacology DNA Methylation DNA-binding proteins DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Enzyme Induction Genes, Reporter Glucocorticoids - pharmacology hepatocytes Liver - enzymology Male P450 induction Rats Rats, Sprague-Dawley Receptors, Glucocorticoid - metabolism Recombinant Fusion Proteins - biosynthesis Transcription, Genetic - drug effects Transfection
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