Polyomavirus Large T Can Support DNA Replication in Human Cells

Human cells are generally thought to be nonpermissive for polyomavirus (Py) DNA replication. Using transient transfection, we show that Py large T-antigen (LT) was able to support replication of a Py origin-containing plasmid in two human cell lines. Replication supported by LT in human cells was sp...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1998-01, Vol.240 (1), p.50-56
Hauptverfasser:	Sverdrup, Francis, Schaffhausen, Brian S., Androphy, Elliot J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Antigens, Polyomavirus Transforming - physiology Bovine papillomavirus 1 - genetics Bovine papillomavirus 1 - physiology Cell Line Cercopithecus aethiops Cytomegalovirus - genetics DNA Primase - metabolism DNA Replication DNA, Viral - biosynthesis Female Humans Mice Polyomavirus - genetics Polyomavirus - physiology Promoter Regions, Genetic Simian virus 40 - genetics Simian virus 40 - physiology Tumor Cells, Cultured Uterine Cervical Neoplasms Virus Replication
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