Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery
Nitroglycerin (0-3 mg) was administeredsublingually to 14patients undergoing cardiac catheterization, and pressure waves compared in the ascending aorta and brachial artery. After nitroglycerin, ascending aortic systolic pressure fell in all cases (by 6–44, average 22 mmHg) whereas brachial systolic...
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| Veröffentlicht in: | European heart journal 1990-02, Vol.11 (2), p.138-144 |
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| container_title | European heart journal |
| container_volume | 11 |
| creator | KELLY, R. P. GIBS, H. H. O'ROURKE, M. F. DALEY, J. E. MANG, K. MORGEN, J. J. AVOLID, A. P. |
| description | Nitroglycerin (0-3 mg) was administeredsublingually to 14patients undergoing cardiac catheterization, and pressure waves compared in the ascending aorta and brachial artery. After nitroglycerin, ascending aortic systolic pressure fell in all cases (by 6–44, average 22 mmHg) whereas brachial systolic pressure remained unchanged (in three) or fell to a lesser degree (4–33, average12 mmHg). Diastolic pressure did not change significantly. Alterations in pressure and in wave contour were explained on the basis of arterial dilation, with reduction in wave reflection. Nitroglycerin reduces left ventricular afterload through arterial dilation as well as preload through venous dilation. This effect on afterload is not apparent from measurement of pressure in the brachial artery. |
| doi_str_mv | 10.1093/oxfordjournals.eurheartj.a059669 |
| format | Article |
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P. ; GIBS, H. H. ; O'ROURKE, M. F. ; DALEY, J. E. ; MANG, K. ; MORGEN, J. J. ; AVOLID, A. P.</creator><creatorcontrib>KELLY, R. P. ; GIBS, H. H. ; O'ROURKE, M. F. ; DALEY, J. E. ; MANG, K. ; MORGEN, J. J. ; AVOLID, A. P.</creatorcontrib><description>Nitroglycerin (0-3 mg) was administeredsublingually to 14patients undergoing cardiac catheterization, and pressure waves compared in the ascending aorta and brachial artery. After nitroglycerin, ascending aortic systolic pressure fell in all cases (by 6–44, average 22 mmHg) whereas brachial systolic pressure remained unchanged (in three) or fell to a lesser degree (4–33, average12 mmHg). Diastolic pressure did not change significantly. Alterations in pressure and in wave contour were explained on the basis of arterial dilation, with reduction in wave reflection. Nitroglycerin reduces left ventricular afterload through arterial dilation as well as preload through venous dilation. This effect on afterload is not apparent from measurement of pressure in the brachial artery.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/oxfordjournals.eurheartj.a059669</identifier><identifier>PMID: 2107077</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Administration, Sublingual ; Adult ; afterload ; Aged ; Aorta - drug effects ; Blood Pressure - drug effects ; Blood Pressure Determination ; Cardiac Catheterization ; Female ; Heart Ventricles - drug effects ; Humans ; Male ; Middle Aged ; Nitroglycerin ; Nitroglycerin - administration & dosage ; Nitroglycerin - pharmacology ; Vasodilation - drug effects ; wave reflection</subject><ispartof>European heart journal, 1990-02, Vol.11 (2), p.138-144</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-a24bf8a7e48b4014932bcea30b82b3f4854cad2646f6c693ab1d4a3d0a0556a63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2107077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KELLY, R. P.</creatorcontrib><creatorcontrib>GIBS, H. H.</creatorcontrib><creatorcontrib>O'ROURKE, M. F.</creatorcontrib><creatorcontrib>DALEY, J. E.</creatorcontrib><creatorcontrib>MANG, K.</creatorcontrib><creatorcontrib>MORGEN, J. J.</creatorcontrib><creatorcontrib>AVOLID, A. P.</creatorcontrib><title>Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Nitroglycerin (0-3 mg) was administeredsublingually to 14patients undergoing cardiac catheterization, and pressure waves compared in the ascending aorta and brachial artery. After nitroglycerin, ascending aortic systolic pressure fell in all cases (by 6–44, average 22 mmHg) whereas brachial systolic pressure remained unchanged (in three) or fell to a lesser degree (4–33, average12 mmHg). Diastolic pressure did not change significantly. Alterations in pressure and in wave contour were explained on the basis of arterial dilation, with reduction in wave reflection. Nitroglycerin reduces left ventricular afterload through arterial dilation as well as preload through venous dilation. This effect on afterload is not apparent from measurement of pressure in the brachial artery.</description><subject>Administration, Sublingual</subject><subject>Adult</subject><subject>afterload</subject><subject>Aged</subject><subject>Aorta - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure Determination</subject><subject>Cardiac Catheterization</subject><subject>Female</subject><subject>Heart Ventricles - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitroglycerin</subject><subject>Nitroglycerin - administration & dosage</subject><subject>Nitroglycerin - pharmacology</subject><subject>Vasodilation - drug effects</subject><subject>wave reflection</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUcFu1DAQtSpQWUo_AcknxCWLHTtOcgNV0CKVwgGkqhdrkozZLEkcxk7V_YT-NV7taiVOo5k3ek_vPcbeS7GWolYf_JPz1G39QhMMYY0LbRAobtcgitqY-oytZJHnWW108YKthKyLzJjq_hV7HcJWCFEZac7ZeS5FKcpyxZ7v-kj-97BrkfqJbyDw0RNyB49JBJoBOTqHbQzcT3xAF_kjTpH6dhmAOLiINHjoeNzAxGGegRLMHfmRjwhhIRz3B-_4TBj2O086wOekN2-QYODJANLuDXvpkie8PM4L9uvL559XN9nt9-uvV59us1YZHTPIdeMqKFFXjRZS1ypvWgQlmipvlNNVoVvocqONM62pFTSy06A6kRIqDBh1wd4deGfyfxcM0Y59aHEYYEK_BFumHE1eqPT48fDYkg-B0NmZ-hFoZ6Ww-zbs_23YUxv22EaieHvUWpoRuxPBMf6EZwe8DxGfTjDQH2tKVRb25v7B3gmjH36Yb7ZW_wBHoKNt</recordid><startdate>19900201</startdate><enddate>19900201</enddate><creator>KELLY, R. P.</creator><creator>GIBS, H. H.</creator><creator>O'ROURKE, M. F.</creator><creator>DALEY, J. E.</creator><creator>MANG, K.</creator><creator>MORGEN, J. J.</creator><creator>AVOLID, A. P.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900201</creationdate><title>Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery</title><author>KELLY, R. P. ; GIBS, H. H. ; O'ROURKE, M. F. ; DALEY, J. E. ; MANG, K. ; MORGEN, J. J. ; AVOLID, A. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-a24bf8a7e48b4014932bcea30b82b3f4854cad2646f6c693ab1d4a3d0a0556a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Administration, Sublingual</topic><topic>Adult</topic><topic>afterload</topic><topic>Aged</topic><topic>Aorta - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure Determination</topic><topic>Cardiac Catheterization</topic><topic>Female</topic><topic>Heart Ventricles - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitroglycerin</topic><topic>Nitroglycerin - administration & dosage</topic><topic>Nitroglycerin - pharmacology</topic><topic>Vasodilation - drug effects</topic><topic>wave reflection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KELLY, R. P.</creatorcontrib><creatorcontrib>GIBS, H. H.</creatorcontrib><creatorcontrib>O'ROURKE, M. F.</creatorcontrib><creatorcontrib>DALEY, J. E.</creatorcontrib><creatorcontrib>MANG, K.</creatorcontrib><creatorcontrib>MORGEN, J. J.</creatorcontrib><creatorcontrib>AVOLID, A. P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KELLY, R. P.</au><au>GIBS, H. H.</au><au>O'ROURKE, M. F.</au><au>DALEY, J. E.</au><au>MANG, K.</au><au>MORGEN, J. J.</au><au>AVOLID, A. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1990-02-01</date><risdate>1990</risdate><volume>11</volume><issue>2</issue><spage>138</spage><epage>144</epage><pages>138-144</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Nitroglycerin (0-3 mg) was administeredsublingually to 14patients undergoing cardiac catheterization, and pressure waves compared in the ascending aorta and brachial artery. After nitroglycerin, ascending aortic systolic pressure fell in all cases (by 6–44, average 22 mmHg) whereas brachial systolic pressure remained unchanged (in three) or fell to a lesser degree (4–33, average12 mmHg). Diastolic pressure did not change significantly. Alterations in pressure and in wave contour were explained on the basis of arterial dilation, with reduction in wave reflection. Nitroglycerin reduces left ventricular afterload through arterial dilation as well as preload through venous dilation. This effect on afterload is not apparent from measurement of pressure in the brachial artery.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>2107077</pmid><doi>10.1093/oxfordjournals.eurheartj.a059669</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-668X |
| ispartof | European heart journal, 1990-02, Vol.11 (2), p.138-144 |
| issn | 0195-668X 1522-9645 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79666253 |
| source | MEDLINE; Oxford University Press Archive |
| subjects | Administration, Sublingual Adult afterload Aged Aorta - drug effects Blood Pressure - drug effects Blood Pressure Determination Cardiac Catheterization Female Heart Ventricles - drug effects Humans Male Middle Aged Nitroglycerin Nitroglycerin - administration & dosage Nitroglycerin - pharmacology Vasodilation - drug effects wave reflection |
| title | Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery |
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