A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes

The protein product of the c-Cbl proto-oncogene is prominently tyrosine phosphorylated in response to insulin in 3T3-L1 adipocytes and not in 3T3-L1 fibroblasts. After insulin-dependent tyrosine phosphorylation, c-Cbl specifically associates with endogenous c-Crk and Fyn. These results suggest a rol...

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Veröffentlicht in:	Molecular and cellular biology 1998-02, Vol.18 (2), p.872-879
Hauptverfasser:	Ribon, V, Printen, J A, Hoffman, N G, Kay, B K, Saltiel, A R
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adipocytes - metabolism Animals Carrier Proteins - chemistry Carrier Proteins - isolation & purification Guanine Nucleotide Exchange Factors Mice Phosphorylation Protein-Tyrosine Kinases - metabolism Proteins - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-cbl Proto-Oncogene Proteins c-crk Proto-Oncogene Proteins c-fyn Receptor, Insulin - metabolism Signal Transduction Tyrosine - metabolism Ubiquitin-Protein Ligases
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