Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study
Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1998-01, Vol.279 (5350), p.563-566 |
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| creator | Chan, June M. Stampfer, Meir J. Giovannucci, Edward Gann, Peter H. Ma, Jing Wilkinson, Peter Hennekens, Charles H. Pollak, Michael |
| description | Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment. |
| doi_str_mv | 10.1126/science.279.5350.563 |
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To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.279.5350.563</identifier><identifier>PMID: 9438850</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Anti smoking movements ; Biological and medical sciences ; Blood ; Blood plasma ; Blood specimen collection ; Body Composition ; Body mass index ; Cancer ; Case-Control Studies ; Cell growth ; Cellular biology ; Confidence Intervals ; Diagnosis ; Disease Susceptibility ; Estrogens ; Growth factors ; Gynecology. Andrology. Obstetrics ; Health risk assessment ; Humans ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor I - analysis ; Insulin-Like Growth Factor II - analysis ; Male ; Male genital diseases ; Males ; Medical sciences ; Middle Aged ; Odds Ratio ; Physicians ; Prospective Studies ; Prostate ; Prostate cancer ; Prostate-Specific Antigen - blood ; Prostatic Neoplasms - etiology ; Reference Groups ; Reference Values ; Regression (Statistics) ; Regression Analysis ; Risk ; Risk Factors ; Scientific Concepts ; Statistical Significance ; Tumors</subject><ispartof>Science (American Association for the Advancement of Science), 1998-01, Vol.279 (5350), p.563-566</ispartof><rights>Copyright 1998 American Association for the Advancement of Science</rights><rights>1998 INIST-CNRS</rights><rights>COPYRIGHT 1998 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1998 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jan 23, 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c782t-b0dcce04d5cf12d4102d13050bfcaa834916ada39027c380cf71a0f8ec91f6593</citedby><cites>FETCH-LOGICAL-c782t-b0dcce04d5cf12d4102d13050bfcaa834916ada39027c380cf71a0f8ec91f6593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2894045$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2894045$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2134453$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9438850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, June M.</creatorcontrib><creatorcontrib>Stampfer, Meir J.</creatorcontrib><creatorcontrib>Giovannucci, Edward</creatorcontrib><creatorcontrib>Gann, Peter H.</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Wilkinson, Peter</creatorcontrib><creatorcontrib>Hennekens, Charles H.</creatorcontrib><creatorcontrib>Pollak, Michael</creatorcontrib><title>Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Anti smoking movements</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood plasma</subject><subject>Blood specimen collection</subject><subject>Body Composition</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Cell growth</subject><subject>Cellular biology</subject><subject>Confidence Intervals</subject><subject>Diagnosis</subject><subject>Disease Susceptibility</subject><subject>Estrogens</subject><subject>Growth factors</subject><subject>Gynecology. Andrology. 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prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>9438850</pmid><doi>10.1126/science.279.5350.563</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1998-01, Vol.279 (5350), p.563-566 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Adult Aged Aged, 80 and over Analysis of Variance Anti smoking movements Biological and medical sciences Blood Blood plasma Blood specimen collection Body Composition Body mass index Cancer Case-Control Studies Cell growth Cellular biology Confidence Intervals Diagnosis Disease Susceptibility Estrogens Growth factors Gynecology. Andrology. Obstetrics Health risk assessment Humans Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - analysis Insulin-Like Growth Factor II - analysis Male Male genital diseases Males Medical sciences Middle Aged Odds Ratio Physicians Prospective Studies Prostate Prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - etiology Reference Groups Reference Values Regression (Statistics) Regression Analysis Risk Risk Factors Scientific Concepts Statistical Significance Tumors |
| title | Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study |
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