Interferon-γ and activin A promote insulin-like growth factor-binding protein-2 and -4 accumulation by human luteinizing granulosa cells, and interferon-γ promotes their apoptosis

Insulin-like growth factor (IGF)-binding proteins (IGFBPs) antagonize IGF and gonadotropin actions on granulosa cells. Human atretic follicles express IGFBP-2 in granulosa cells more strongly and contain higher levels of IGFBP-2 and IGFBP-4 than healthy follicles. We studied the effects of interfero...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 1998, Vol.83 (1), p.179-186
Hauptverfasser:	CATALDO, N. A, FUJIMOTO, V. Y, JAFFE, R. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Activins Amniotic Fluid - physiology Apoptosis - drug effects Biological and medical sciences Cells, Cultured Culture Media Female Fundamental and applied biological sciences. Psychology Granulosa Cells - cytology Granulosa Cells - drug effects Granulosa Cells - physiology Hormone metabolism and regulation Humans Inhibins - pharmacology Insulin-Like Growth Factor Binding Protein 2 - biosynthesis Insulin-Like Growth Factor Binding Protein 4 - biosynthesis Interferon-gamma - pharmacology Kinetics Luteinizing Hormone - pharmacology Male Mammalian female genital system Metalloendopeptidases - metabolism Pregnancy Pregnancy-Associated Plasma Protein-A Recombinant Proteins - pharmacology Semen - physiology Vertebrates: reproduction
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