Exercise modulates the insulin-induced translocation of glucose transporters in rat skeletal muscle
Insulin and acute exercise (45 min of treadmill run) increased glucose uptake into perfused rat hindlimbs 5-fold and 3.2-fold, respectively. Following exercise, insulin treatment resulted in a further increase in glucose uptake. The subcellular distribution of the muscle glucose transporters GLUT-1...
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| Veröffentlicht in: | FEBS letters 1990-02, Vol.261 (2), p.256-260 |
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| creator | Douen, Andre G. Ramlal, Toolsie Cartee, Gregory D. Klip, Amira |
| description | Insulin and acute exercise (45 min of treadmill run) increased glucose uptake into perfused rat hindlimbs 5-fold and 3.2-fold, respectively. Following exercise, insulin treatment resulted in a further increase in glucose uptake. The subcellular distribution of the muscle glucose transporters GLUT-1 and GLUT-4 was determined in plasma membranes and intracellular membranes. Neither exercise nor exercise→ insulin treatment altered the distribution of GLUT-1 transporters in these medmbrane fractions. In contrast, exercise, insulin and exercise→ insulin treatment caused comparable increases in GLUT-4 transporters in the plasma membrane. The results suggest that exercise might limit insulin-induced GLUT-4 recruitment and that following exercise, insulin may alter the intrinsic activity of plasma membrane glucose transporters. |
| doi_str_mv | 10.1016/0014-5793(90)80566-2 |
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Following exercise, insulin treatment resulted in a further increase in glucose uptake. The subcellular distribution of the muscle glucose transporters GLUT-1 and GLUT-4 was determined in plasma membranes and intracellular membranes. Neither exercise nor exercise→ insulin treatment altered the distribution of GLUT-1 transporters in these medmbrane fractions. In contrast, exercise, insulin and exercise→ insulin treatment caused comparable increases in GLUT-4 transporters in the plasma membrane. 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Following exercise, insulin treatment resulted in a further increase in glucose uptake. The subcellular distribution of the muscle glucose transporters GLUT-1 and GLUT-4 was determined in plasma membranes and intracellular membranes. Neither exercise nor exercise→ insulin treatment altered the distribution of GLUT-1 transporters in these medmbrane fractions. In contrast, exercise, insulin and exercise→ insulin treatment caused comparable increases in GLUT-4 transporters in the plasma membrane. The results suggest that exercise might limit insulin-induced GLUT-4 recruitment and that following exercise, insulin may alter the intrinsic activity of plasma membrane glucose transporters.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Cell Membrane - metabolism</subject><subject>Cell physiology</subject><subject>Cytochalasin B - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - metabolism</subject><subject>Glucose uptake</subject><subject>insulin</subject><subject>Insulin - pharmacology</subject><subject>Insulin action</subject><subject>Male</subject><subject>Membrane and intracellular transports</subject><subject>Molecular and cellular biology</subject><subject>Monosaccharide Transport Proteins - metabolism</subject><subject>Muscles - drug effects</subject><subject>Muscles - metabolism</subject><subject>Physical Exertion - physiology</subject><subject>physical training</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>skeletal muscle</subject><subject>Space life sciences</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcuOFCEUJUYz9oz-gSZsNOOilFdBsZlEJ91qMokbXRMKbilKFS1UqfP3Ut2dcaeuCPc8LpyD0BNKXlJC5StCqGhapfmlJi860krZsHtoQzvFGy5kdx9t7igP0XkpX0m9d1SfoTNGVacV3SC3_QXZhQJ4TH6JdoaC5y-Aw1SWGKYmTH5x4PGc7VRicnYOacJpwJ_j4lKVHYB9yjPkUlU42xmXbxBhthGPS3ERHqEHg40FHp_OC_Rpt_14_a65-fD2_fXrm8a1mrOGd971DBRIDnYgQoKkgvQdU8Cp74WnTvSkl4oPylHFoReCeitBWFfhjl-g50fffU7fFyizGUNxEKOdIC3FKC0la7X8J5G2bauZpJUojkSXUykZBrPPYbT51lBi1hLMmrBZEzaamEMJhlXZ05P_0o_g70Sn1Cv-7ITb4mwcaoS1gj_eWrVMirbydkfezxDh9r92m932DVuBda7JYbo-6OpoBDX-HwGyKS7AVIsNGdxsfAp__9FvPEe4PQ</recordid><startdate>19900226</startdate><enddate>19900226</enddate><creator>Douen, Andre G.</creator><creator>Ramlal, Toolsie</creator><creator>Cartee, Gregory D.</creator><creator>Klip, Amira</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19900226</creationdate><title>Exercise modulates the insulin-induced translocation of glucose transporters in rat skeletal muscle</title><author>Douen, Andre G. ; Ramlal, Toolsie ; Cartee, Gregory D. ; Klip, Amira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5932-38dcb2e7e63eaf046e6140b827e31db4d1c4b0b673f7c173eb441da6e4acdb483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Cell Membrane - metabolism</topic><topic>Cell physiology</topic><topic>Cytochalasin B - metabolism</topic><topic>Fundamental and applied biological sciences. 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Following exercise, insulin treatment resulted in a further increase in glucose uptake. The subcellular distribution of the muscle glucose transporters GLUT-1 and GLUT-4 was determined in plasma membranes and intracellular membranes. Neither exercise nor exercise→ insulin treatment altered the distribution of GLUT-1 transporters in these medmbrane fractions. In contrast, exercise, insulin and exercise→ insulin treatment caused comparable increases in GLUT-4 transporters in the plasma membrane. The results suggest that exercise might limit insulin-induced GLUT-4 recruitment and that following exercise, insulin may alter the intrinsic activity of plasma membrane glucose transporters.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2178971</pmid><doi>10.1016/0014-5793(90)80566-2</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1990-02, Vol.261 (2), p.256-260 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blotting, Western Cell Membrane - metabolism Cell physiology Cytochalasin B - metabolism Fundamental and applied biological sciences. Psychology Glucose - metabolism Glucose uptake insulin Insulin - pharmacology Insulin action Male Membrane and intracellular transports Molecular and cellular biology Monosaccharide Transport Proteins - metabolism Muscles - drug effects Muscles - metabolism Physical Exertion - physiology physical training Rats Rats, Inbred Strains skeletal muscle Space life sciences |
| title | Exercise modulates the insulin-induced translocation of glucose transporters in rat skeletal muscle |
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