Novel Technetium (III)-Q Complexes for Functional Imaging of Multidrug Resistance (MDR1) P-Glycoprotein

Overexpression of the multidrug resistance (MDR1) P-glycoprotein (Pgp) correlates with cancer chemotherapeutic failure. Lipophilic cationic radiopharmaceuticals such as 99mTc-sestamibi, 99mTc-tetrofosmin and 99Tc-furifosmin (Tc-Q12) have been validated as transport substrates for the MDR1 Pgp and ma...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 1998-01, Vol.39 (1), p.77-86
Hauptverfasser:	Crankshaw, Carolyn L, Marmion, Mary, Luker, Gary D, Rao, Vallabhaneni, Dahlheimer, Julie, Burleigh, B. Daniel, Webb, Elizabeth, Deutsch, Karen F, Piwnica-Worms, David
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette, Sub-Family B, Member 1 Biological and medical sciences Contrast media. Radiopharmaceuticals Drug Resistance, Neoplasm Humans Medical sciences Organophosphorus Compounds Organotechnetium Compounds Pharmacology. Drug treatments Radiopharmaceuticals Technetium Tc 99m Sestamibi Tumor Cells, Cultured
Online-Zugang:	Volltext
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