Norepinephrine Uptake Is Enhanced in Discrete Telencephalic and Diencephalic Areas and Nuclei in Prehepatic Portal Hypertensive Rats
Several evidences support the hypothesis that central catecholamines may play a significant role in the production and/or maintenance of different alterations that characterize portal hypertension. The aim of the present work was to study the possible modifications in norepinephrine (NE) metabolism...
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| Veröffentlicht in: | Brain research bulletin 1998, Vol.45 (2), p.153-156 |
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| creator | Lemberg, Abraham Perazzo, Juan Romay, Salvador Eizayaga, Francisco Vatta, Marcelo Rodriguez–Fermepin, Martin Bianciotti, Liliana Monserrat, Alberto Fernandez, Belisario |
| description | Several evidences support the hypothesis that central catecholamines may play a significant role in the production and/or maintenance of different alterations that characterize portal hypertension. The aim of the present work was to study the possible modifications in norepinephrine (NE) metabolism in several telencephalic and diencephalic areas rich in NE in experimental prehepatic portal hypertension. NE uptake was studied as an index of NE metabolism. The experiments were carried out
in vitro
in encephalic areas and nuclei, obtained according to the punch-out technique. Results indicated that portal hypertensive rats showed an enhancement of NE uptake in olfactory bulb (OB), preoptic area (PA), and supraoptic, periventricular, paraventricular, and arcuate nuclei (SON, PeVN, PaVN, and AN, respectively) compared to sham-operated rats. However, no modifications on NE uptake was observed in the median eminence (ME). Present results suggest that the changes observed in central NE uptake may be related to the development and/or maintenance of the portal hypertensive state. |
| doi_str_mv | 10.1016/S0361-9230(97)00331-6 |
| format | Article |
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in vitro
in encephalic areas and nuclei, obtained according to the punch-out technique. Results indicated that portal hypertensive rats showed an enhancement of NE uptake in olfactory bulb (OB), preoptic area (PA), and supraoptic, periventricular, paraventricular, and arcuate nuclei (SON, PeVN, PaVN, and AN, respectively) compared to sham-operated rats. However, no modifications on NE uptake was observed in the median eminence (ME). Present results suggest that the changes observed in central NE uptake may be related to the development and/or maintenance of the portal hypertensive state.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/S0361-9230(97)00331-6</identifier><identifier>PMID: 9443832</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Arcuate nucleus ; Arterial hypertension. Arterial hypotension ; Basal Ganglia - metabolism ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - physiology ; Cardiology. Vascular system ; Diencephalon - metabolism ; Experimental diseases ; Hypertension, Portal - metabolism ; Male ; Median eminence ; Medical sciences ; Norepinephrine - metabolism ; Olfactory bulb ; Paraventricular nucleus ; Periventricular nucleus ; Prehepatic portal hypertension ; Preoptic area ; Rats ; Rats, Wistar ; Supraoptic nucleus ; Telencephalon - metabolism</subject><ispartof>Brain research bulletin, 1998, Vol.45 (2), p.153-156</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-4bf5ba89c429b4f3efafead9c238eb26fdf49ba5dc6f637609146989baed1a103</citedby><cites>FETCH-LOGICAL-c420t-4bf5ba89c429b4f3efafead9c238eb26fdf49ba5dc6f637609146989baed1a103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0361923097003316$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2108259$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9443832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lemberg, Abraham</creatorcontrib><creatorcontrib>Perazzo, Juan</creatorcontrib><creatorcontrib>Romay, Salvador</creatorcontrib><creatorcontrib>Eizayaga, Francisco</creatorcontrib><creatorcontrib>Vatta, Marcelo</creatorcontrib><creatorcontrib>Rodriguez–Fermepin, Martin</creatorcontrib><creatorcontrib>Bianciotti, Liliana</creatorcontrib><creatorcontrib>Monserrat, Alberto</creatorcontrib><creatorcontrib>Fernandez, Belisario</creatorcontrib><title>Norepinephrine Uptake Is Enhanced in Discrete Telencephalic and Diencephalic Areas and Nuclei in Prehepatic Portal Hypertensive Rats</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Several evidences support the hypothesis that central catecholamines may play a significant role in the production and/or maintenance of different alterations that characterize portal hypertension. The aim of the present work was to study the possible modifications in norepinephrine (NE) metabolism in several telencephalic and diencephalic areas rich in NE in experimental prehepatic portal hypertension. NE uptake was studied as an index of NE metabolism. The experiments were carried out
in vitro
in encephalic areas and nuclei, obtained according to the punch-out technique. Results indicated that portal hypertensive rats showed an enhancement of NE uptake in olfactory bulb (OB), preoptic area (PA), and supraoptic, periventricular, paraventricular, and arcuate nuclei (SON, PeVN, PaVN, and AN, respectively) compared to sham-operated rats. However, no modifications on NE uptake was observed in the median eminence (ME). Present results suggest that the changes observed in central NE uptake may be related to the development and/or maintenance of the portal hypertensive state.</description><subject>Animals</subject><subject>Arcuate nucleus</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Basal Ganglia - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Diencephalon - metabolism</subject><subject>Experimental diseases</subject><subject>Hypertension, Portal - metabolism</subject><subject>Male</subject><subject>Median eminence</subject><subject>Medical sciences</subject><subject>Norepinephrine - metabolism</subject><subject>Olfactory bulb</subject><subject>Paraventricular nucleus</subject><subject>Periventricular nucleus</subject><subject>Prehepatic portal hypertension</subject><subject>Preoptic area</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Supraoptic nucleus</subject><subject>Telencephalon - metabolism</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFSEYhYnR1NvqT2gyC2PsYhQGBoaVaWq1TZraaLsm78BLLjp3ZgRuk-794XI_cuOuGwjnPIevQ8gpox8ZZfLTT8olq3XD6QetzijlnNXyBVmwTvG6UUK9JIsD8pocp_SLUiq7Vh6RIy0E73izIH9vp4hzGHFexjJWD3OG31hdp-pyXMJo0VVhrL6EZCNmrO5xwCLOSxiCrWB0xfpPOI8IaSvfru2AYZO9i7jEGXKx76aYYaiunmaMGccUHrH6ATm9Ia88DAnf7ucT8vD18v7iqr75_u364vymtqKhuRa9b3vodFnpXniOHjyC07bhHfaN9M4L3UPrrPSSK0k1E1J3RULHgFF-Qt7v9p3j9GeNKZtVeRgOA4w4rZNRWkqmZPcsyKRQnEpewHYH2jilFNGbOYYVxCfDqNnUZLY1mU0HRiuzrcnIkjvdH7DuV-gOqX0vxX-39yFZGHwsVYR0wBpGu6bVBfu8w7D82mPAaJLd9uFCRJuNm8IzF_kHzz6wyw</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Lemberg, Abraham</creator><creator>Perazzo, Juan</creator><creator>Romay, Salvador</creator><creator>Eizayaga, Francisco</creator><creator>Vatta, Marcelo</creator><creator>Rodriguez–Fermepin, Martin</creator><creator>Bianciotti, Liliana</creator><creator>Monserrat, Alberto</creator><creator>Fernandez, Belisario</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Norepinephrine Uptake Is Enhanced in Discrete Telencephalic and Diencephalic Areas and Nuclei in Prehepatic Portal Hypertensive Rats</title><author>Lemberg, Abraham ; Perazzo, Juan ; Romay, Salvador ; Eizayaga, Francisco ; Vatta, Marcelo ; Rodriguez–Fermepin, Martin ; Bianciotti, Liliana ; Monserrat, Alberto ; Fernandez, Belisario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-4bf5ba89c429b4f3efafead9c238eb26fdf49ba5dc6f637609146989baed1a103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Arcuate nucleus</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Basal Ganglia - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Diencephalon - metabolism</topic><topic>Experimental diseases</topic><topic>Hypertension, Portal - metabolism</topic><topic>Male</topic><topic>Median eminence</topic><topic>Medical sciences</topic><topic>Norepinephrine - metabolism</topic><topic>Olfactory bulb</topic><topic>Paraventricular nucleus</topic><topic>Periventricular nucleus</topic><topic>Prehepatic portal hypertension</topic><topic>Preoptic area</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Supraoptic nucleus</topic><topic>Telencephalon - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lemberg, Abraham</creatorcontrib><creatorcontrib>Perazzo, Juan</creatorcontrib><creatorcontrib>Romay, Salvador</creatorcontrib><creatorcontrib>Eizayaga, Francisco</creatorcontrib><creatorcontrib>Vatta, Marcelo</creatorcontrib><creatorcontrib>Rodriguez–Fermepin, Martin</creatorcontrib><creatorcontrib>Bianciotti, Liliana</creatorcontrib><creatorcontrib>Monserrat, Alberto</creatorcontrib><creatorcontrib>Fernandez, Belisario</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lemberg, Abraham</au><au>Perazzo, Juan</au><au>Romay, Salvador</au><au>Eizayaga, Francisco</au><au>Vatta, Marcelo</au><au>Rodriguez–Fermepin, Martin</au><au>Bianciotti, Liliana</au><au>Monserrat, Alberto</au><au>Fernandez, Belisario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Norepinephrine Uptake Is Enhanced in Discrete Telencephalic and Diencephalic Areas and Nuclei in Prehepatic Portal Hypertensive Rats</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1998</date><risdate>1998</risdate><volume>45</volume><issue>2</issue><spage>153</spage><epage>156</epage><pages>153-156</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>Several evidences support the hypothesis that central catecholamines may play a significant role in the production and/or maintenance of different alterations that characterize portal hypertension. The aim of the present work was to study the possible modifications in norepinephrine (NE) metabolism in several telencephalic and diencephalic areas rich in NE in experimental prehepatic portal hypertension. NE uptake was studied as an index of NE metabolism. The experiments were carried out
in vitro
in encephalic areas and nuclei, obtained according to the punch-out technique. Results indicated that portal hypertensive rats showed an enhancement of NE uptake in olfactory bulb (OB), preoptic area (PA), and supraoptic, periventricular, paraventricular, and arcuate nuclei (SON, PeVN, PaVN, and AN, respectively) compared to sham-operated rats. However, no modifications on NE uptake was observed in the median eminence (ME). Present results suggest that the changes observed in central NE uptake may be related to the development and/or maintenance of the portal hypertensive state.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9443832</pmid><doi>10.1016/S0361-9230(97)00331-6</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Arcuate nucleus Arterial hypertension. Arterial hypotension Basal Ganglia - metabolism Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Cardiology. Vascular system Diencephalon - metabolism Experimental diseases Hypertension, Portal - metabolism Male Median eminence Medical sciences Norepinephrine - metabolism Olfactory bulb Paraventricular nucleus Periventricular nucleus Prehepatic portal hypertension Preoptic area Rats Rats, Wistar Supraoptic nucleus Telencephalon - metabolism |
| title | Norepinephrine Uptake Is Enhanced in Discrete Telencephalic and Diencephalic Areas and Nuclei in Prehepatic Portal Hypertensive Rats |
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