Association of an HLA-DQ Allele With Clinical Tuberculosis

CONTEXT.— Although tuberculosis (TB) is the leading worldwide cause of death due to an infectious disease, the extent to which progressive clinical disease is associated with genetic host factors remains undefined. OBJECTIVE.— To determine the distribution of HLA antigens and the frequency of 2 alle...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 1998-01, Vol.279 (3), p.226-228
Hauptverfasser:	Goldfeld, Anne E, Delgado, Julio C, Thim, Sok, Bozon, M. Viviana, Uglialoro, Adele M, Turbay, David, Cohen, Carol, Yunis, Edmond J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alleles Bacterial diseases Biological and medical sciences Cambodia Case-Control Studies Child Child, Preschool Female Genes Genetic Predisposition to Disease Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class II - genetics HLA-DQ Antigens - genetics Human bacterial diseases Humans Infectious diseases Male Medical sciences Middle Aged Nucleic Acid Hybridization Polymorphism, Restriction Fragment Length Tropical medicine Tuberculosis Tuberculosis - genetics Tuberculosis - immunology Tuberculosis and atypical mycobacterial infections Tumor Necrosis Factor-alpha - genetics
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