Granulosa cells as a source and target organ for tumor necrosis factor-α
Tumor necrosis factor (TNF-α), a 17 kDa cytokine, is a product of activated macrophages which was recently shown to be produced by rat and bovine granulosa cells. In the present work, human granulosa cells derived from preovulatory follicles were used. It was demonstrated that human granulosa cells...
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| Veröffentlicht in: | FEBS letters 1990-02, Vol.261 (2), p.253-255 |
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| creator | Zolti, Mati Meirom, Ruth Shemesh, Mordechai Wollach, David Mashiach, Shlomo Shore, Laurence Ben Rafael, Zion |
| description | Tumor necrosis factor (TNF-α), a 17 kDa cytokine, is a product of activated macrophages which was recently shown to be produced by rat and bovine granulosa cells. In the present work, human granulosa cells derived from preovulatory follicles were used. It was demonstrated that human granulosa cells produce TNF-α (5–10 units/300 000 cells per 15 h). This production was increased by addition of follicle-stimulating hormone or by a combination of human chorionic gonadotrophin and CSF to the culture media. TNF was also found in bovine follicular fluid and the concentration was higher in the periovulatory than mid-cycle follicles. TNF-α was found to increase prostaglandin F-2α production by human granulosa cells (
P < 0.001). We conclude that granulosa cells are both a source and target organ for TNF-α. |
| doi_str_mv | 10.1016/0014-5793(90)80565-Z |
| format | Article |
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Humoral and cellular immunity</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Chorionic Gonadotropin - pharmacology</topic><topic>Colony-Stimulating Factors - pharmacology</topic><topic>Dinoprost - biosynthesis</topic><topic>Dinoprost - pharmacology</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - pharmacology</topic><topic>Follicle-stimulating hormone</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Granulosa cell</topic><topic>Granulosa Cells - drug effects</topic><topic>Granulosa Cells - metabolism</topic><topic>Human, Bovine</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>Macrophage Colony-Stimulating Factor</topic><topic>Ovarian follicle</topic><topic>Regulatory factors and their cellular receptors</topic><topic>Tumor necrosis factor</topic><topic>tumor necrosis factor- alpha</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>Tumor Necrosis Factor-alpha - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zolti, Mati</creatorcontrib><creatorcontrib>Meirom, Ruth</creatorcontrib><creatorcontrib>Shemesh, Mordechai</creatorcontrib><creatorcontrib>Wollach, David</creatorcontrib><creatorcontrib>Mashiach, Shlomo</creatorcontrib><creatorcontrib>Shore, Laurence</creatorcontrib><creatorcontrib>Ben Rafael, Zion</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zolti, Mati</au><au>Meirom, Ruth</au><au>Shemesh, Mordechai</au><au>Wollach, David</au><au>Mashiach, Shlomo</au><au>Shore, Laurence</au><au>Ben Rafael, Zion</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulosa cells as a source and target organ for tumor necrosis factor-α</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1990-02-26</date><risdate>1990</risdate><volume>261</volume><issue>2</issue><spage>253</spage><epage>255</epage><pages>253-255</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Tumor necrosis factor (TNF-α), a 17 kDa cytokine, is a product of activated macrophages which was recently shown to be produced by rat and bovine granulosa cells. 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| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1990-02, Vol.261 (2), p.253-255 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Cells, Cultured Chorionic Gonadotropin - pharmacology Colony-Stimulating Factors - pharmacology Dinoprost - biosynthesis Dinoprost - pharmacology Female Follicle Stimulating Hormone - pharmacology Follicle-stimulating hormone Fundamental and applied biological sciences. Psychology Fundamental immunology Granulosa cell Granulosa Cells - drug effects Granulosa Cells - metabolism Human, Bovine Humans Immunobiology Lymphokines, interleukins ( function, expression) Macrophage Colony-Stimulating Factor Ovarian follicle Regulatory factors and their cellular receptors Tumor necrosis factor tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - pharmacology |
| title | Granulosa cells as a source and target organ for tumor necrosis factor-α |
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