Morphine Increases Plasma Immunoreactive Atrial Natriuretic Peptide Levels in Humans
Plasma immunoreactive α-atrial natriuretic peptide (IR α-ANP) levels were determined before, and at 5 and 10 min after bolus intravenous administration of morphine (0·15 or 0·30 mg/kg) in 21 otherwise healthy human subjects who underwent elective surgery. Five min after injection IR α-ANP levels had...
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| Veröffentlicht in: | Annals of clinical biochemistry 1990-01, Vol.27 (1), p.21-24 |
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| container_title | Annals of clinical biochemistry |
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| creator | Öğütman, Ç Özben, T Şadan, G Trakya, A İsbir, M |
| description | Plasma immunoreactive α-atrial natriuretic peptide (IR α-ANP) levels were determined before, and at 5 and 10 min after bolus intravenous administration of morphine (0·15 or 0·30 mg/kg) in 21 otherwise healthy human subjects who underwent elective surgery. Five min after injection IR α-ANP levels had nearly doubled in response to both doses of morphine. At 10 min, plasma IR α-ANP concentrations were lower than at 5 min in the 0·15 mg/kg group suggesting that IR α-ANP levels peak shortly after morphine administration. Morphine has been widely used in the treatment of acute left ventricular failure and ANP is a recently discovered hormone which possesses unique favourable effects in patients with congestive heart failure when administered exogenously. The combination of these data suggests an important potential role for ANP in the mechanism of action of morphine in the treatment of acute left ventricular failure. |
| doi_str_mv | 10.1177/000456329002700105 |
| format | Article |
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Five min after injection IR α-ANP levels had nearly doubled in response to both doses of morphine. At 10 min, plasma IR α-ANP concentrations were lower than at 5 min in the 0·15 mg/kg group suggesting that IR α-ANP levels peak shortly after morphine administration. Morphine has been widely used in the treatment of acute left ventricular failure and ANP is a recently discovered hormone which possesses unique favourable effects in patients with congestive heart failure when administered exogenously. The combination of these data suggests an important potential role for ANP in the mechanism of action of morphine in the treatment of acute left ventricular failure.</description><identifier>ISSN: 0004-5632</identifier><identifier>EISSN: 1758-1001</identifier><identifier>DOI: 10.1177/000456329002700105</identifier><identifier>PMID: 2138000</identifier><identifier>CODEN: ACBOBU</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Atrial Natriuretic Factor - blood ; Biological and medical sciences ; Endocrinology ; Female ; Heart Failure - blood ; Heart Failure - physiopathology ; Hemodynamics - drug effects ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Morphine - pharmacology ; Pathology. Cytology. Biochemistry. Spectrometry. 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Five min after injection IR α-ANP levels had nearly doubled in response to both doses of morphine. At 10 min, plasma IR α-ANP concentrations were lower than at 5 min in the 0·15 mg/kg group suggesting that IR α-ANP levels peak shortly after morphine administration. Morphine has been widely used in the treatment of acute left ventricular failure and ANP is a recently discovered hormone which possesses unique favourable effects in patients with congestive heart failure when administered exogenously. The combination of these data suggests an important potential role for ANP in the mechanism of action of morphine in the treatment of acute left ventricular failure.</description><subject>Adult</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Biological and medical sciences</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - physiopathology</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morphine - pharmacology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><issn>0004-5632</issn><issn>1758-1001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEGmPwB5CQckDcypz0I-1xmoBNGrDDOFdZ6kKmfpG0k_j3pGq1CxIny_Zjv_ZLyC2DR8aEmANAEEY-TwC4AGAQnpEpE2HsMZedk2kPeD1xSa6sPcDATciEMz922ZTsXmvTfOkK6bpSBqVFS7eFtKWk67LsqtrVVKuPSBet0bKgb9LFzmCrFd1i0-oM6QaPWFiqK7rqSlnZa3KRy8LizRhn5OP5abdceZv3l_VysfGUH4nWS3IVyFAo7qtYZHEQ7zMUCInK0Z2XS44hoHsw2EOAjOdJzHnAReRHqBTyyJ-Rh2FvY-rvDm2bltoqLApZYd3ZVCRRKELgDuQDqExtrcE8bYwupflJGaS9lelfK93Q3bi925eYnUZG71z_fuxLq2SRG1kpbU9YFCfgB732fMCs_MT0UHemcp78J_wLHoCIBA</recordid><startdate>199001</startdate><enddate>199001</enddate><creator>Öğütman, Ç</creator><creator>Özben, T</creator><creator>Şadan, G</creator><creator>Trakya, A</creator><creator>İsbir, M</creator><general>SAGE Publications</general><general>Royal Society of Medicine Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199001</creationdate><title>Morphine Increases Plasma Immunoreactive Atrial Natriuretic Peptide Levels in Humans</title><author>Öğütman, Ç ; Özben, T ; Şadan, G ; Trakya, A ; İsbir, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-9fc4a57c23c87d848bde7e09cfe138fa2e50e4564b04e12f9822427636ecce263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>Biological and medical sciences</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - physiopathology</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Morphine - pharmacology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Öğütman, Ç</creatorcontrib><creatorcontrib>Özben, T</creatorcontrib><creatorcontrib>Şadan, G</creatorcontrib><creatorcontrib>Trakya, A</creatorcontrib><creatorcontrib>İsbir, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Öğütman, Ç</au><au>Özben, T</au><au>Şadan, G</au><au>Trakya, A</au><au>İsbir, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphine Increases Plasma Immunoreactive Atrial Natriuretic Peptide Levels in Humans</atitle><jtitle>Annals of clinical biochemistry</jtitle><addtitle>Ann Clin Biochem</addtitle><date>1990-01</date><risdate>1990</risdate><volume>27</volume><issue>1</issue><spage>21</spage><epage>24</epage><pages>21-24</pages><issn>0004-5632</issn><eissn>1758-1001</eissn><coden>ACBOBU</coden><abstract>Plasma immunoreactive α-atrial natriuretic peptide (IR α-ANP) levels were determined before, and at 5 and 10 min after bolus intravenous administration of morphine (0·15 or 0·30 mg/kg) in 21 otherwise healthy human subjects who underwent elective surgery. Five min after injection IR α-ANP levels had nearly doubled in response to both doses of morphine. At 10 min, plasma IR α-ANP concentrations were lower than at 5 min in the 0·15 mg/kg group suggesting that IR α-ANP levels peak shortly after morphine administration. Morphine has been widely used in the treatment of acute left ventricular failure and ANP is a recently discovered hormone which possesses unique favourable effects in patients with congestive heart failure when administered exogenously. The combination of these data suggests an important potential role for ANP in the mechanism of action of morphine in the treatment of acute left ventricular failure.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>2138000</pmid><doi>10.1177/000456329002700105</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Atrial Natriuretic Factor - blood Biological and medical sciences Endocrinology Female Heart Failure - blood Heart Failure - physiopathology Hemodynamics - drug effects Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Morphine - pharmacology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques |
| title | Morphine Increases Plasma Immunoreactive Atrial Natriuretic Peptide Levels in Humans |
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