Prognostic significance of tumor markers in colorectal cancer patients: DNA index, S-phase fraction, p53 expression, and Ki-67 index
Risk of colorectal cancer recurrence has traditionally been determined by use of pathologic staging. However, it is apparent that subgroups of patients exist within tumor stages whose clinical behavior differs. This study was undertaken to identify tumor-associated factors that might be predictive o...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 1997-05, Vol.1 (3), p.266-273 |
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| creator | Chen, Ya-Ting Henk, Mary Jo Carney, Kathy-Jean Wong, W.Douglas Rothenberger, David A. Zheng, Tongzhang Feygin, Marina Madoff, Robert D. |
| description | Risk of colorectal cancer recurrence has traditionally been determined by use of pathologic staging. However, it is apparent that subgroups of patients exist within tumor stages whose clinical behavior differs. This study was undertaken to identify tumor-associated factors that might be predictive of outcome in patients with intermediate stages who will benefit the most from postsurgical adjuvant therapy. Seventy patients with stage II and III colorectal cancer were assessed for DNA index, S-phase fraction, p53 expression, and Ki-67 index. Tumor recurrence was analyzed by means of nonparametric tests and Cox proportional hazard models incorporating standard clinical and pathologic criteria. Of the four prognostic markers evaluated, Ki-67 index was significantly associated with disease recurrence (
P = 0.02), whereas DNA index, S-phase fraction, and p53 expression were not. After stratification by tumor stage, significant associations between Ki-67 index and disease recurrence were retained in stage II tumors (
P = 0.01) but not in stage III tumors (
P = 0.23). Cox proportional hazard regression analysis indicated that among stage II patients, those with a Ki-67 index >45% were associated with 6.5 times greater risk for disease recurrence than those with a Ki-67 index ≤45%. It was concluded that an elevated Ki-67 index is associated with an increased risk of tumor recurrence in stage II colorectal cancer. |
| doi_str_mv | 10.1016/S1091-255X(97)80119-9 |
| format | Article |
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P = 0.02), whereas DNA index, S-phase fraction, and p53 expression were not. After stratification by tumor stage, significant associations between Ki-67 index and disease recurrence were retained in stage II tumors (
P = 0.01) but not in stage III tumors (
P = 0.23). Cox proportional hazard regression analysis indicated that among stage II patients, those with a Ki-67 index >45% were associated with 6.5 times greater risk for disease recurrence than those with a Ki-67 index ≤45%. It was concluded that an elevated Ki-67 index is associated with an increased risk of tumor recurrence in stage II colorectal cancer.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1016/S1091-255X(97)80119-9</identifier><identifier>PMID: 9834357</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Biomarkers, Tumor - analysis ; Colorectal cancer ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Deoxyribonucleic acid ; Disease-Free Survival ; DNA ; DNA, Neoplasm - genetics ; Female ; Fractions ; Humans ; Ki-67 Antigen - analysis ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Ploidies ; Prognosis ; Risk Factors ; S Phase ; Studies ; Survival Rate ; Tumor Suppressor Protein p53 - analysis ; Tumors</subject><ispartof>Journal of gastrointestinal surgery, 1997-05, Vol.1 (3), p.266-273</ispartof><rights>1997</rights><rights>The Society for Surgery of the Alimentary Tract, Inc. 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3509-5edcc46ed44dc07f9035f5a542f27fce6a543eba5621593c58b3ad5d283ffb3b3</citedby><cites>FETCH-LOGICAL-c3509-5edcc46ed44dc07f9035f5a542f27fce6a543eba5621593c58b3ad5d283ffb3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9834357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ya-Ting</creatorcontrib><creatorcontrib>Henk, Mary Jo</creatorcontrib><creatorcontrib>Carney, Kathy-Jean</creatorcontrib><creatorcontrib>Wong, W.Douglas</creatorcontrib><creatorcontrib>Rothenberger, David A.</creatorcontrib><creatorcontrib>Zheng, Tongzhang</creatorcontrib><creatorcontrib>Feygin, Marina</creatorcontrib><creatorcontrib>Madoff, Robert D.</creatorcontrib><title>Prognostic significance of tumor markers in colorectal cancer patients: DNA index, S-phase fraction, p53 expression, and Ki-67 index</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><description>Risk of colorectal cancer recurrence has traditionally been determined by use of pathologic staging. However, it is apparent that subgroups of patients exist within tumor stages whose clinical behavior differs. This study was undertaken to identify tumor-associated factors that might be predictive of outcome in patients with intermediate stages who will benefit the most from postsurgical adjuvant therapy. Seventy patients with stage II and III colorectal cancer were assessed for DNA index, S-phase fraction, p53 expression, and Ki-67 index. Tumor recurrence was analyzed by means of nonparametric tests and Cox proportional hazard models incorporating standard clinical and pathologic criteria. Of the four prognostic markers evaluated, Ki-67 index was significantly associated with disease recurrence (
P = 0.02), whereas DNA index, S-phase fraction, and p53 expression were not. After stratification by tumor stage, significant associations between Ki-67 index and disease recurrence were retained in stage II tumors (
P = 0.01) but not in stage III tumors (
P = 0.23). Cox proportional hazard regression analysis indicated that among stage II patients, those with a Ki-67 index >45% were associated with 6.5 times greater risk for disease recurrence than those with a Ki-67 index ≤45%. It was concluded that an elevated Ki-67 index is associated with an increased risk of tumor recurrence in stage II colorectal cancer.</description><subject>Aged</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Deoxyribonucleic acid</subject><subject>Disease-Free Survival</subject><subject>DNA</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Fractions</subject><subject>Humans</subject><subject>Ki-67 Antigen - analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Ploidies</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>S Phase</subject><subject>Studies</subject><subject>Survival Rate</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><subject>Tumors</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkV1rFjEQhYNYaq3-hEJAEIVuTTabZNMbKfWjxaJCFbwL2WRSU_dN1mRX6r0_3LwfeuGNVzPDPGcSzkHoiJITSqh4cU2Jok3L-ZdnSj7vCaWqUffQAe0lazrRivu1_4M8QA9LuSWESkL7fbSvetYxLg_Qr4853cRU5mBxCTcx-GBNtICTx_OyShmvTP4GueAQsU1jymBnM-INlPFk5gBxLqf41fuziji4O8bXzfTVFMA-GzuHFI_xxBmGuylDKZvZRIffhUbIreQR2vNmLPB4Vw_R5zevP51fNFcf3l6en101lnGiGg7O2k6A6zpnifSKMO654V3rW-ktiNoyGAwXLeWKWd4PzDju2p55P7CBHaKn27tTTt8XKLNehWJhHE2EtBQtleCCKVbBJ_-At2nJsf5NU0rblgna80rxLWVzKiWD11MO1a6fmhK9zkhvMtLrALSSepORVlV3tLu-DCtwf1W7UOr-5XYP1YsfAbIutrpswYW1-9ql8J8XfgOuRKF8</recordid><startdate>199705</startdate><enddate>199705</enddate><creator>Chen, Ya-Ting</creator><creator>Henk, Mary Jo</creator><creator>Carney, Kathy-Jean</creator><creator>Wong, W.Douglas</creator><creator>Rothenberger, David A.</creator><creator>Zheng, Tongzhang</creator><creator>Feygin, Marina</creator><creator>Madoff, Robert D.</creator><general>Elsevier Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>199705</creationdate><title>Prognostic significance of tumor markers in colorectal cancer patients: DNA index, S-phase fraction, p53 expression, and Ki-67 index</title><author>Chen, Ya-Ting ; 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P = 0.02), whereas DNA index, S-phase fraction, and p53 expression were not. After stratification by tumor stage, significant associations between Ki-67 index and disease recurrence were retained in stage II tumors (
P = 0.01) but not in stage III tumors (
P = 0.23). Cox proportional hazard regression analysis indicated that among stage II patients, those with a Ki-67 index >45% were associated with 6.5 times greater risk for disease recurrence than those with a Ki-67 index ≤45%. It was concluded that an elevated Ki-67 index is associated with an increased risk of tumor recurrence in stage II colorectal cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9834357</pmid><doi>10.1016/S1091-255X(97)80119-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of gastrointestinal surgery, 1997-05, Vol.1 (3), p.266-273 |
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| subjects | Aged Biomarkers, Tumor - analysis Colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Deoxyribonucleic acid Disease-Free Survival DNA DNA, Neoplasm - genetics Female Fractions Humans Ki-67 Antigen - analysis Male Middle Aged Neoplasm Recurrence, Local Ploidies Prognosis Risk Factors S Phase Studies Survival Rate Tumor Suppressor Protein p53 - analysis Tumors |
| title | Prognostic significance of tumor markers in colorectal cancer patients: DNA index, S-phase fraction, p53 expression, and Ki-67 index |
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