Peripheral neuropathy associated with IgM monoclonal gammopathy: Correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases
Forty cases of polyneuropathy associated with IgM monoclonal gammopathy were retrospectively studied to investigate the relevance of clinical and electrophysiological features to M‐protein antibody activity. There were 26 men and 14 women; mean age was 65 ± 11.7 years at the time of the study. Thirt...
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| Veröffentlicht in: | Muscle & nerve 1998-01, Vol.21 (1), p.55-62 |
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| creator | Chassande, Bénédicte Léger, Jean-Marc Younes-Chennoufi, Amena Ben Bengoufa, Djaouida Maisonobe, Thierry Bouche, Pierre Baumann, Nicole |
| description | Forty cases of polyneuropathy associated with IgM monoclonal gammopathy were retrospectively studied to investigate the relevance of clinical and electrophysiological features to M‐protein antibody activity. There were 26 men and 14 women; mean age was 65 ± 11.7 years at the time of the study. Thirty‐nine patients had a symmetrical polyneuropathy, of whom 13 had a predominantly sensory and 17 a purely sensory neuropathy (i.e., 30 sensory neuropathies). The remaining patient had a multifocal mononeuropathy. Electrophysiological studies allowed the polyneuropathies to be classified as demyelinating in 33 cases (82.5%) and axonal in 6 cases. Antibody studies disclosed anti‐MAG antibodies in 65% and anti‐SGPG antibodies in 82.5% of patients. Anti‐MAG antibodies were associated with only demyelinating polyneuropathies. Anti‐SGPG antibodies were found in 91% of demyelinating polyneuropathies and 50% of axonopathies. In addition, anti‐MAG/SGPG antibody activity was significantly correlated with the subgroup of sensory neuropathies (P < 0.01). Last, antisulfatide antibodies were found at significant titers in 18 cases, and their presence was significantly correlated with anti‐MAG/SGPG antibody activity, but not with some clinical/electrophysiological features. © 1998 John Wiley & Sons, Inc. Muscle Nerve, 21: 55–62, 1998. |
| doi_str_mv | 10.1002/(SICI)1097-4598(199801)21:1<55::AID-MUS8>3.0.CO;2-F |
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Last, antisulfatide antibodies were found at significant titers in 18 cases, and their presence was significantly correlated with anti‐MAG/SGPG antibody activity, but not with some clinical/electrophysiological features. © 1998 John Wiley & Sons, Inc. Muscle Nerve, 21: 55–62, 1998.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/(SICI)1097-4598(199801)21:1<55::AID-MUS8>3.0.CO;2-F</identifier><identifier>PMID: 9427224</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; anti-MAG ; antibodies ; antisulfatide antibodies ; Autoantibodies - blood ; Axons - physiology ; Biological and medical sciences ; Connectin ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Disease Progression ; Electromyography ; Electrophysiology - methods ; Female ; Humans ; Immunoglobulin M ; M-protein ; Male ; Medical sciences ; Middle Aged ; Muscle Proteins ; Myelin-Associated Glycoprotein - immunology ; Myeloma Proteins - immunology ; Nervous system (semeiology, syndromes) ; Neural Conduction ; Neurology ; Paraproteinemias - complications ; Paraproteinemias - immunology ; Paraproteinemias - physiopathology ; Paresthesia - etiology ; Paresthesia - physiopathology ; Patient Selection ; Peripheral Nervous System Diseases - etiology ; Peripheral Nervous System Diseases - immunology ; Peripheral Nervous System Diseases - physiopathology ; Recurrence ; Retrospective Studies</subject><ispartof>Muscle & nerve, 1998-01, Vol.21 (1), p.55-62</ispartof><rights>Copyright © 1998 John Wiley & Sons, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4258-41a6c7dd4e1ba55e5700456bebd42be6039f9913ffd4d8798c4c9608791c02663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-4598%28199801%2921%3A1%3C55%3A%3AAID-MUS8%3E3.0.CO%3B2-F$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-4598%28199801%2921%3A1%3C55%3A%3AAID-MUS8%3E3.0.CO%3B2-F$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2113230$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9427224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chassande, Bénédicte</creatorcontrib><creatorcontrib>Léger, Jean-Marc</creatorcontrib><creatorcontrib>Younes-Chennoufi, Amena Ben</creatorcontrib><creatorcontrib>Bengoufa, Djaouida</creatorcontrib><creatorcontrib>Maisonobe, Thierry</creatorcontrib><creatorcontrib>Bouche, Pierre</creatorcontrib><creatorcontrib>Baumann, Nicole</creatorcontrib><title>Peripheral neuropathy associated with IgM monoclonal gammopathy: Correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Forty cases of polyneuropathy associated with IgM monoclonal gammopathy were retrospectively studied to investigate the relevance of clinical and electrophysiological features to M‐protein antibody activity. There were 26 men and 14 women; mean age was 65 ± 11.7 years at the time of the study. Thirty‐nine patients had a symmetrical polyneuropathy, of whom 13 had a predominantly sensory and 17 a purely sensory neuropathy (i.e., 30 sensory neuropathies). The remaining patient had a multifocal mononeuropathy. Electrophysiological studies allowed the polyneuropathies to be classified as demyelinating in 33 cases (82.5%) and axonal in 6 cases. Antibody studies disclosed anti‐MAG antibodies in 65% and anti‐SGPG antibodies in 82.5% of patients. Anti‐MAG antibodies were associated with only demyelinating polyneuropathies. Anti‐SGPG antibodies were found in 91% of demyelinating polyneuropathies and 50% of axonopathies. In addition, anti‐MAG/SGPG antibody activity was significantly correlated with the subgroup of sensory neuropathies (P < 0.01). Last, antisulfatide antibodies were found at significant titers in 18 cases, and their presence was significantly correlated with anti‐MAG/SGPG antibody activity, but not with some clinical/electrophysiological features. © 1998 John Wiley & Sons, Inc. Muscle Nerve, 21: 55–62, 1998.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>anti-MAG</subject><subject>antibodies</subject><subject>antisulfatide antibodies</subject><subject>Autoantibodies - blood</subject><subject>Axons - physiology</subject><subject>Biological and medical sciences</subject><subject>Connectin</subject><subject>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</subject><subject>Disease Progression</subject><subject>Electromyography</subject><subject>Electrophysiology - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin M</subject><subject>M-protein</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle Proteins</subject><subject>Myelin-Associated Glycoprotein - immunology</subject><subject>Myeloma Proteins - immunology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neural Conduction</subject><subject>Neurology</subject><subject>Paraproteinemias - complications</subject><subject>Paraproteinemias - immunology</subject><subject>Paraproteinemias - physiopathology</subject><subject>Paresthesia - etiology</subject><subject>Paresthesia - physiopathology</subject><subject>Patient Selection</subject><subject>Peripheral Nervous System Diseases - etiology</subject><subject>Peripheral Nervous System Diseases - immunology</subject><subject>Peripheral Nervous System Diseases - physiopathology</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEUhUcIVELhEZC8QKhdTGp7_lOEVFISIjWkKK1gd-Xx3ElcJuNgO4S8EY-Jh0RhAcIbX9vH5x77C4JLRvuMUn5xNp8MJ-eMFlkYJ0V-xooip-ycswF7kySDwdXkOpzez_O3UZ_2h7NLHo4eBb2j_nHQoyzOwzQqvjwNnln7QClleZqdBCdFzDPO417w8xaNWi_RiIa0uDF6LdxyR4S1WirhsCJb5ZZkspiSlW61bHTrlQuxWu2VAzLUxmAjnNKtJSW6LWJLpuHaaIeqJaJ1qtSVt5ROfVfOF21FZKNaJUVzgQ1K57sud1bpRi-6TVKjcBuDlvj7MSVSWLTPgye1aCy-OMynwf3o_d3wQ3gzG0-GVzehjHmShzETqcyqKkZWiiTBJKM0TtISyyrmJaY0KuqiYFFdV3GVZ0UuY1mk1FdMUp6m0Wnweu_rH_Btg9bBSlmJTSNa1BsLWZEmfmReON8LpdHWGqxhbdRKmB0wCh0_gI4fdDyg4wF7fsAZMEgSAM8POn4QAYXhDDiMvOvLQ_tNucLq6HkA5s9fHc6F9V9VG9FKZY8yzljEI_on3FY1uPsr2f-D_SPX77V3Dfeuyjr8cXQV5iukWZQl8PnjGK5v391F8_EnYNEvL5DVcA</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Chassande, Bénédicte</creator><creator>Léger, Jean-Marc</creator><creator>Younes-Chennoufi, Amena Ben</creator><creator>Bengoufa, Djaouida</creator><creator>Maisonobe, Thierry</creator><creator>Bouche, Pierre</creator><creator>Baumann, Nicole</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>Peripheral neuropathy associated with IgM monoclonal gammopathy: Correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases</title><author>Chassande, Bénédicte ; Léger, Jean-Marc ; Younes-Chennoufi, Amena Ben ; Bengoufa, Djaouida ; Maisonobe, Thierry ; Bouche, Pierre ; Baumann, Nicole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4258-41a6c7dd4e1ba55e5700456bebd42be6039f9913ffd4d8798c4c9608791c02663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>anti-MAG</topic><topic>antibodies</topic><topic>antisulfatide antibodies</topic><topic>Autoantibodies - blood</topic><topic>Axons - physiology</topic><topic>Biological and medical sciences</topic><topic>Connectin</topic><topic>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</topic><topic>Disease Progression</topic><topic>Electromyography</topic><topic>Electrophysiology - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin M</topic><topic>M-protein</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle Proteins</topic><topic>Myelin-Associated Glycoprotein - immunology</topic><topic>Myeloma Proteins - immunology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neural Conduction</topic><topic>Neurology</topic><topic>Paraproteinemias - complications</topic><topic>Paraproteinemias - immunology</topic><topic>Paraproteinemias - physiopathology</topic><topic>Paresthesia - etiology</topic><topic>Paresthesia - physiopathology</topic><topic>Patient Selection</topic><topic>Peripheral Nervous System Diseases - etiology</topic><topic>Peripheral Nervous System Diseases - immunology</topic><topic>Peripheral Nervous System Diseases - physiopathology</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chassande, Bénédicte</creatorcontrib><creatorcontrib>Léger, Jean-Marc</creatorcontrib><creatorcontrib>Younes-Chennoufi, Amena Ben</creatorcontrib><creatorcontrib>Bengoufa, Djaouida</creatorcontrib><creatorcontrib>Maisonobe, Thierry</creatorcontrib><creatorcontrib>Bouche, Pierre</creatorcontrib><creatorcontrib>Baumann, Nicole</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chassande, Bénédicte</au><au>Léger, Jean-Marc</au><au>Younes-Chennoufi, Amena Ben</au><au>Bengoufa, Djaouida</au><au>Maisonobe, Thierry</au><au>Bouche, Pierre</au><au>Baumann, Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral neuropathy associated with IgM monoclonal gammopathy: Correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>1998-01</date><risdate>1998</risdate><volume>21</volume><issue>1</issue><spage>55</spage><epage>62</epage><pages>55-62</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Forty cases of polyneuropathy associated with IgM monoclonal gammopathy were retrospectively studied to investigate the relevance of clinical and electrophysiological features to M‐protein antibody activity. There were 26 men and 14 women; mean age was 65 ± 11.7 years at the time of the study. Thirty‐nine patients had a symmetrical polyneuropathy, of whom 13 had a predominantly sensory and 17 a purely sensory neuropathy (i.e., 30 sensory neuropathies). The remaining patient had a multifocal mononeuropathy. Electrophysiological studies allowed the polyneuropathies to be classified as demyelinating in 33 cases (82.5%) and axonal in 6 cases. Antibody studies disclosed anti‐MAG antibodies in 65% and anti‐SGPG antibodies in 82.5% of patients. Anti‐MAG antibodies were associated with only demyelinating polyneuropathies. Anti‐SGPG antibodies were found in 91% of demyelinating polyneuropathies and 50% of axonopathies. In addition, anti‐MAG/SGPG antibody activity was significantly correlated with the subgroup of sensory neuropathies (P < 0.01). Last, antisulfatide antibodies were found at significant titers in 18 cases, and their presence was significantly correlated with anti‐MAG/SGPG antibody activity, but not with some clinical/electrophysiological features. © 1998 John Wiley & Sons, Inc. Muscle Nerve, 21: 55–62, 1998.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9427224</pmid><doi>10.1002/(SICI)1097-4598(199801)21:1<55::AID-MUS8>3.0.CO;2-F</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Analysis of Variance anti-MAG antibodies antisulfatide antibodies Autoantibodies - blood Axons - physiology Biological and medical sciences Connectin Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Disease Progression Electromyography Electrophysiology - methods Female Humans Immunoglobulin M M-protein Male Medical sciences Middle Aged Muscle Proteins Myelin-Associated Glycoprotein - immunology Myeloma Proteins - immunology Nervous system (semeiology, syndromes) Neural Conduction Neurology Paraproteinemias - complications Paraproteinemias - immunology Paraproteinemias - physiopathology Paresthesia - etiology Paresthesia - physiopathology Patient Selection Peripheral Nervous System Diseases - etiology Peripheral Nervous System Diseases - immunology Peripheral Nervous System Diseases - physiopathology Recurrence Retrospective Studies |
| title | Peripheral neuropathy associated with IgM monoclonal gammopathy: Correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases |
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