Manifestations and treatment of human parvovirus B19 infection in immunocompromised patients
We diagnosed infections from human parvovirus B19 in three patients by using dot-blot hybrodization and a polymerase chain reaction to detect B19 DNA and using an enzyme immunoassay to detect IgG and IgM to B19. For 5 months a 5-year-old boy with acute lymphoblastic leukemia in remission had anemia...
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| Veröffentlicht in: | The Journal of pediatrics 1990-03, Vol.116 (3), p.355-359 |
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| container_title | The Journal of pediatrics |
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| creator | Koch, William C. Massey, Gita Russell, Clifton E. Adler, Stuart P. |
| description | We diagnosed infections from human parvovirus B19 in three patients by using dot-blot hybrodization and a polymerase chain reaction to detect B19 DNA and using an enzyme immunoassay to detect IgG and IgM to B19. For 5 months a 5-year-old boy with acute lymphoblastic leukemia in remission had anemia without reticulocytes or bone marrow erythrocyte precursors. His serum lacked IgG and IgM to B19 but contained B19 DNA. He received gamma globulin intravenously (0.4 gm/kg/day for 5 days); his viremia promptly cleared and reticulocytosis developed. A 14-year-old boy with acute lymphoblastic leukemia in remission had fever, rash, neutropenia ( |
| doi_str_mv | 10.1016/S0022-3476(05)82820-3 |
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3), and a hemophagocytic syndrome lasting 3 weeks. His serum contained IgM to B19 and B19 DNA. Without therapy, IgG to B19 developed; although low levels of B19 DNA persisted, the leukocyte count returned to normal. In a 19-year-old patient with systemic lupus erythrmatosus and hemolytic anemia, an aplastic crisis lasted 2 weeks. Her serum lacked IgG and IgM to B19 but contained B19 DNA. Without therapy, IgG and IgM to B19 appeared, viremia diminished, and reticulocytosis occurred. These patients illustrate the varied manifestations of chronic B19 infections, the importance of DNA detection for diagnosis, and the possible efficacy of gamma globulin therapy</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(05)82820-3</identifier><identifier>PMID: 1689774</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Child, Preschool ; DNA, Viral - analysis ; Female ; gamma-Globulins - therapeutic use ; Humans ; Immune Tolerance ; Immunoenzyme Techniques ; Lupus Erythematosus, Systemic - complications ; Male ; Parvoviridae Infections - diagnosis ; Parvoviridae Infections - etiology ; Parvoviridae Infections - immunology ; Parvoviridae Infections - therapy ; Polymerase Chain Reaction ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</subject><ispartof>The Journal of pediatrics, 1990-03, Vol.116 (3), p.355-359</ispartof><rights>1990 The C.V. Mosby Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-1fa57bc688a278b0c8596b57c9675cd99651f025bd54dd2bee1ccc1ac57ec0363</citedby><cites>FETCH-LOGICAL-c412t-1fa57bc688a278b0c8596b57c9675cd99651f025bd54dd2bee1ccc1ac57ec0363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347605828203$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1689774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koch, William C.</creatorcontrib><creatorcontrib>Massey, Gita</creatorcontrib><creatorcontrib>Russell, Clifton E.</creatorcontrib><creatorcontrib>Adler, Stuart P.</creatorcontrib><title>Manifestations and treatment of human parvovirus B19 infection in immunocompromised patients</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>We diagnosed infections from human parvovirus B19 in three patients by using dot-blot hybrodization and a polymerase chain reaction to detect B19 DNA and using an enzyme immunoassay to detect IgG and IgM to B19. For 5 months a 5-year-old boy with acute lymphoblastic leukemia in remission had anemia without reticulocytes or bone marrow erythrocyte precursors. His serum lacked IgG and IgM to B19 but contained B19 DNA. He received gamma globulin intravenously (0.4 gm/kg/day for 5 days); his viremia promptly cleared and reticulocytosis developed. A 14-year-old boy with acute lymphoblastic leukemia in remission had fever, rash, neutropenia (<300 leukocytes/mm
3), and a hemophagocytic syndrome lasting 3 weeks. His serum contained IgM to B19 and B19 DNA. Without therapy, IgG to B19 developed; although low levels of B19 DNA persisted, the leukocyte count returned to normal. In a 19-year-old patient with systemic lupus erythrmatosus and hemolytic anemia, an aplastic crisis lasted 2 weeks. Her serum lacked IgG and IgM to B19 but contained B19 DNA. Without therapy, IgG and IgM to B19 appeared, viremia diminished, and reticulocytosis occurred. These patients illustrate the varied manifestations of chronic B19 infections, the importance of DNA detection for diagnosis, and the possible efficacy of gamma globulin therapy</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child, Preschool</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>gamma-Globulins - therapeutic use</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immunoenzyme Techniques</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Male</subject><subject>Parvoviridae Infections - diagnosis</subject><subject>Parvoviridae Infections - etiology</subject><subject>Parvoviridae Infections - immunology</subject><subject>Parvoviridae Infections - therapy</subject><subject>Polymerase Chain Reaction</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9LxDAQxYMo67r6ERZ6Ej1UJ2mTtCfRxX-w4kG9CSFNUoxsmzVpF_z2pttFj55mYN6befNDaI7hAgNmly8AhKRZztkZ0POCFATSbA9NMZQ8ZUWW7aPpr-QQHYXwCQBlDjBBE8yKkvN8it6fZGtrEzrZWdeGRLY66byRXWPaLnF18tE3sk3W0m_cxvo-JDe4TGxbGzUYYpfYpulbp1yz9q6xweio7my0h2N0UMtVMCe7OkNvd7evi4d0-Xz_uLhepirHpEtxLSmvFCsKSXhRgSpoySrKVck4VbosGcU1EFppmmtNKmOwUgpLRblRkLFshk7HvTHBVx-fETGHMquVbI3rg-BxAyU8i0I6CpV3IXhTi7W3jfTfAoMYqIotVTEgE0DFlqoYfPPdgb5qjP5zjRjj_Gqcm_jlxhovgooElNHWR1BCO_vPhR-G8Iiz</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>Koch, William C.</creator><creator>Massey, Gita</creator><creator>Russell, Clifton E.</creator><creator>Adler, Stuart P.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900301</creationdate><title>Manifestations and treatment of human parvovirus B19 infection in immunocompromised patients</title><author>Koch, William C. ; Massey, Gita ; Russell, Clifton E. ; Adler, Stuart P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-1fa57bc688a278b0c8596b57c9675cd99651f025bd54dd2bee1ccc1ac57ec0363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Child, Preschool</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>gamma-Globulins - therapeutic use</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immunoenzyme Techniques</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Male</topic><topic>Parvoviridae Infections - diagnosis</topic><topic>Parvoviridae Infections - etiology</topic><topic>Parvoviridae Infections - immunology</topic><topic>Parvoviridae Infections - therapy</topic><topic>Polymerase Chain Reaction</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koch, William C.</creatorcontrib><creatorcontrib>Massey, Gita</creatorcontrib><creatorcontrib>Russell, Clifton E.</creatorcontrib><creatorcontrib>Adler, Stuart P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koch, William C.</au><au>Massey, Gita</au><au>Russell, Clifton E.</au><au>Adler, Stuart P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manifestations and treatment of human parvovirus B19 infection in immunocompromised patients</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>116</volume><issue>3</issue><spage>355</spage><epage>359</epage><pages>355-359</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>We diagnosed infections from human parvovirus B19 in three patients by using dot-blot hybrodization and a polymerase chain reaction to detect B19 DNA and using an enzyme immunoassay to detect IgG and IgM to B19. For 5 months a 5-year-old boy with acute lymphoblastic leukemia in remission had anemia without reticulocytes or bone marrow erythrocyte precursors. His serum lacked IgG and IgM to B19 but contained B19 DNA. He received gamma globulin intravenously (0.4 gm/kg/day for 5 days); his viremia promptly cleared and reticulocytosis developed. A 14-year-old boy with acute lymphoblastic leukemia in remission had fever, rash, neutropenia (<300 leukocytes/mm
3), and a hemophagocytic syndrome lasting 3 weeks. His serum contained IgM to B19 and B19 DNA. Without therapy, IgG to B19 developed; although low levels of B19 DNA persisted, the leukocyte count returned to normal. In a 19-year-old patient with systemic lupus erythrmatosus and hemolytic anemia, an aplastic crisis lasted 2 weeks. Her serum lacked IgG and IgM to B19 but contained B19 DNA. Without therapy, IgG and IgM to B19 appeared, viremia diminished, and reticulocytosis occurred. These patients illustrate the varied manifestations of chronic B19 infections, the importance of DNA detection for diagnosis, and the possible efficacy of gamma globulin therapy</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>1689774</pmid><doi>10.1016/S0022-3476(05)82820-3</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Child, Preschool DNA, Viral - analysis Female gamma-Globulins - therapeutic use Humans Immune Tolerance Immunoenzyme Techniques Lupus Erythematosus, Systemic - complications Male Parvoviridae Infections - diagnosis Parvoviridae Infections - etiology Parvoviridae Infections - immunology Parvoviridae Infections - therapy Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications |
| title | Manifestations and treatment of human parvovirus B19 infection in immunocompromised patients |
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