Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors

To determine the earliest changes that occur in the retina after the onset of ectopic expression of vascular endothelial growth factor (VEGF) by photoreceptors in transgenic mice, to characterize the development of neovascularization (NV), and to determine the feasibility of using these mice to test...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1998-01, Vol.39 (1), p.180-188
Hauptverfasser:	Tobe, T, Okamoto, N, Vinores, MA, Derevjanik, NL, Vinores, SA, Zack, DJ, Campochiaro, PA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences DNA Primers - chemistry Endothelial Growth Factors - genetics Endothelial Growth Factors - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Fluorescent Antibody Technique, Indirect Immunohistochemistry Lymphokines - genetics Lymphokines - metabolism Medical sciences Mice Mice, Transgenic Microscopy, Confocal Ophthalmology Photoreceptor Cells - metabolism Photoreceptor Cells - pathology Polymerase Chain Reaction Retinal Neovascularization - etiology Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Retinal Vessels - metabolism Retinal Vessels - pathology Retinal Vessels - ultrastructure Retinopathies Rhodopsin - genetics Rhodopsin - metabolism RNA, Messenger - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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