Cytotoxic sterols from the formosan brown alga Turbinaria ornata

Abstract Two hydroperoxysterols 24-hydroperoxy-24-vinyl-cholesterol (1) and 29-hydroperoxystigmasta-5,24(28)-dien-3β-ol (2), and fucosterol (3) were isolated from the brown alga TURBINARIA ORNATA (Sargassaceae). Hydroperoxide 2 is a new natural compound and was converted into 29-hydroxystigmasta-5,2...

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Veröffentlicht in:	Planta medica 1997-12, Vol.63 (6), p.571-572
Hauptverfasser:	Sheu, J.H, Wang, G.H, Sung, P.J, Chiu, Y.H, Duh, C.Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences cell lines chemical composition chemical structure cytotoxic compounds cytotoxicity General pharmacology Letters Medical sciences neoplasms nuclear magnetic resonance spectroscopy Phaeophycophyta Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments spectral analysis sterols
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Zusammenfassung:	Abstract Two hydroperoxysterols 24-hydroperoxy-24-vinyl-cholesterol (1) and 29-hydroperoxystigmasta-5,24(28)-dien-3β-ol (2), and fucosterol (3) were isolated from the brown alga TURBINARIA ORNATA (Sargassaceae). Hydroperoxide 2 is a new natural compound and was converted into 29-hydroxystigmasta-5,24 (28)-dien-3β-ol (4) by reaction with LAH. Sterols 1, 2, and 4 exhibited cytotoxicity against various cancer cell lines.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-957772