Myeloperoxidase catalysed cooxidative metabolism of methimazole: Oxidation of glutathione and NADH by free radical intermediates

The myeloperoxidase catalysed oxidation of methimazole in the presence of NADH or GSH resulted in oxygen uptake suggesting that metabolism proceeded via a one electron mechanism. The GSH was oxidised to GSSG and the thiyl radical could be trapped with DMPO while NADH was oxidized to NAD +. Metabolis...

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Veröffentlicht in:	Chemico-biological interactions 1990, Vol.73 (2), p.279-295
Hauptverfasser:	McGirr, Larry G., Jatoe, Samuel D., O'Brien, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Free Radicals Glutathione - metabolism Horseradish Peroxidase - metabolism Hydrogen Peroxide - metabolism Iodides - pharmacology Methimazole Methimazole - metabolism Myeloperoxidase NAD - metabolism Oxidation-Reduction Oxygen - metabolism Peroxidase - metabolism Superoxide Dismutase - pharmacology Thiourea - metabolism Thiyl radicals
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