Serum and pleural adenosine deaminase. Correlation with lymphocytic populations
This study attempts to correlate levels of ADA in tuberculous and neoplastic pleural exudates with the different immunologic cellular expressions that follow these clinical situations. Seventy-three patients with pleural effusion were studied in order to assess ADA activity (pleural and serum); in 2...
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| Veröffentlicht in: | Chest 1990-03, Vol.97 (3), p.605-610 |
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| creator | BAGANHA, M. F PEGO, A LIMA, M. A GASPAR, E. V CORDEIRO, A. R |
| description | This study attempts to correlate levels of ADA in tuberculous and neoplastic pleural exudates with the different immunologic
cellular expressions that follow these clinical situations. Seventy-three patients with pleural effusion were studied in order
to assess ADA activity (pleural and serum); in 25 of them, a study of delayed cellular immunity (pleural and sanguineous)
was performed through B, CD3, CD4, and CD8 lymphocytic populations. The activity of ADA was determined, and the study of lymphocytic
populations was made through the use of monoclonal antibodies. The data obtained showed the following: levels of ADA were
significantly (p less than 0.0005) higher in the pleural fluid and the serum of tuberculous effusions compared to neoplastic
effusions; percentages of CD3 and CD4 T-cells were significantly (p less than 0.05 and p less than 0.0005, respectively) greater
in tuberculous effusions. The statistical study of the levels of ADA activity and the percentage of CD4 T-cells in pleural
exudates produced a significant regression curve (r = 0.612 and p less than 0.0001) which showed a positive correlation between
these two parameters. The pathogenic implications of these results suggest the possibility that ADA could be a new marker
of cell-mediated immune activity. |
| doi_str_mv | 10.1378/chest.97.3.605 |
| format | Article |
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cellular expressions that follow these clinical situations. Seventy-three patients with pleural effusion were studied in order
to assess ADA activity (pleural and serum); in 25 of them, a study of delayed cellular immunity (pleural and sanguineous)
was performed through B, CD3, CD4, and CD8 lymphocytic populations. The activity of ADA was determined, and the study of lymphocytic
populations was made through the use of monoclonal antibodies. The data obtained showed the following: levels of ADA were
significantly (p less than 0.0005) higher in the pleural fluid and the serum of tuberculous effusions compared to neoplastic
effusions; percentages of CD3 and CD4 T-cells were significantly (p less than 0.05 and p less than 0.0005, respectively) greater
in tuberculous effusions. The statistical study of the levels of ADA activity and the percentage of CD4 T-cells in pleural
exudates produced a significant regression curve (r = 0.612 and p less than 0.0001) which showed a positive correlation between
these two parameters. The pathogenic implications of these results suggest the possibility that ADA could be a new marker
of cell-mediated immune activity.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.97.3.605</identifier><identifier>PMID: 1689629</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Adenosine Deaminase - analysis ; Adenosine Deaminase - blood ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; B-Lymphocytes - pathology ; Biological and medical sciences ; Child ; Epitopes ; Female ; Humans ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; Nucleoside Deaminases - blood ; Pleural Effusion - enzymology ; Pleural Effusion - pathology ; Pleural Neoplasms - enzymology ; Pleural Neoplasms - pathology ; Pneumology ; T-Lymphocytes - immunology ; T-Lymphocytes - pathology ; T-Lymphocytes, Helper-Inducer - pathology ; T-Lymphocytes, Regulatory - pathology ; Tuberculosis, Pleural - enzymology ; Tuberculosis, Pleural - pathology</subject><ispartof>Chest, 1990-03, Vol.97 (3), p.605-610</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4614207$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1689629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BAGANHA, M. F</creatorcontrib><creatorcontrib>PEGO, A</creatorcontrib><creatorcontrib>LIMA, M. A</creatorcontrib><creatorcontrib>GASPAR, E. V</creatorcontrib><creatorcontrib>CORDEIRO, A. R</creatorcontrib><title>Serum and pleural adenosine deaminase. Correlation with lymphocytic populations</title><title>Chest</title><addtitle>Chest</addtitle><description>This study attempts to correlate levels of ADA in tuberculous and neoplastic pleural exudates with the different immunologic
cellular expressions that follow these clinical situations. Seventy-three patients with pleural effusion were studied in order
to assess ADA activity (pleural and serum); in 25 of them, a study of delayed cellular immunity (pleural and sanguineous)
was performed through B, CD3, CD4, and CD8 lymphocytic populations. The activity of ADA was determined, and the study of lymphocytic
populations was made through the use of monoclonal antibodies. The data obtained showed the following: levels of ADA were
significantly (p less than 0.0005) higher in the pleural fluid and the serum of tuberculous effusions compared to neoplastic
effusions; percentages of CD3 and CD4 T-cells were significantly (p less than 0.05 and p less than 0.0005, respectively) greater
in tuberculous effusions. The statistical study of the levels of ADA activity and the percentage of CD4 T-cells in pleural
exudates produced a significant regression curve (r = 0.612 and p less than 0.0001) which showed a positive correlation between
these two parameters. The pathogenic implications of these results suggest the possibility that ADA could be a new marker
of cell-mediated immune activity.</description><subject>Adenosine Deaminase - analysis</subject><subject>Adenosine Deaminase - blood</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>B-Lymphocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Epitopes</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nucleoside Deaminases - blood</subject><subject>Pleural Effusion - enzymology</subject><subject>Pleural Effusion - pathology</subject><subject>Pleural Neoplasms - enzymology</subject><subject>Pleural Neoplasms - pathology</subject><subject>Pneumology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - pathology</subject><subject>T-Lymphocytes, Helper-Inducer - pathology</subject><subject>T-Lymphocytes, Regulatory - pathology</subject><subject>Tuberculosis, Pleural - enzymology</subject><subject>Tuberculosis, Pleural - pathology</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtLxDAUhYMo4_jYuhO6EHeteTRJs5TBFwy4UNflNr1jM6QPkxaZf291BheXy-V8nAvnEHLFaMaELu5sg3HMjM5Epqg8IktmBEuFzMUxWVLKeCqU4afkLMYtnW9m1IIsmCqM4mZJXt8wTG0CXZ0MHqcAPoEauz66DpMaoXUdRMySVR8Cehhd3yXfbmwSv2uHpre70dlk6Idpr8ULcrIBH_HysM_Jx-PD--o5Xb8-vazu12nDdT6mFVaF1qIyteWKc6zEJq85aJQ1U1pSpPk8G81ZLbFSsrAMNNCqsNJKA1qck9u97xD6r2mOoGxdtOg9dNhPsdRGSSE0n8HrAzhVLdblEFwLYVceEpj1m4MO0YLfBOisi_9YrljO6e-_bI817rP5dgHL2IL3s6ko_yrY9lPowBtdinIuQvwAXDp8hg</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>BAGANHA, M. F</creator><creator>PEGO, A</creator><creator>LIMA, M. A</creator><creator>GASPAR, E. V</creator><creator>CORDEIRO, A. R</creator><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19900301</creationdate><title>Serum and pleural adenosine deaminase. Correlation with lymphocytic populations</title><author>BAGANHA, M. F ; PEGO, A ; LIMA, M. A ; GASPAR, E. V ; CORDEIRO, A. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h274t-beb8773b9dc2622eb3f4d2a7e5d16750e040e0f721d5eb658c1a7a0b8c5c59a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adenosine Deaminase - analysis</topic><topic>Adenosine Deaminase - blood</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>B-Lymphocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Epitopes</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nucleoside Deaminases - blood</topic><topic>Pleural Effusion - enzymology</topic><topic>Pleural Effusion - pathology</topic><topic>Pleural Neoplasms - enzymology</topic><topic>Pleural Neoplasms - pathology</topic><topic>Pneumology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - pathology</topic><topic>T-Lymphocytes, Helper-Inducer - pathology</topic><topic>T-Lymphocytes, Regulatory - pathology</topic><topic>Tuberculosis, Pleural - enzymology</topic><topic>Tuberculosis, Pleural - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BAGANHA, M. F</creatorcontrib><creatorcontrib>PEGO, A</creatorcontrib><creatorcontrib>LIMA, M. A</creatorcontrib><creatorcontrib>GASPAR, E. V</creatorcontrib><creatorcontrib>CORDEIRO, A. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BAGANHA, M. F</au><au>PEGO, A</au><au>LIMA, M. A</au><au>GASPAR, E. V</au><au>CORDEIRO, A. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum and pleural adenosine deaminase. Correlation with lymphocytic populations</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>97</volume><issue>3</issue><spage>605</spage><epage>610</epage><pages>605-610</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>This study attempts to correlate levels of ADA in tuberculous and neoplastic pleural exudates with the different immunologic
cellular expressions that follow these clinical situations. Seventy-three patients with pleural effusion were studied in order
to assess ADA activity (pleural and serum); in 25 of them, a study of delayed cellular immunity (pleural and sanguineous)
was performed through B, CD3, CD4, and CD8 lymphocytic populations. The activity of ADA was determined, and the study of lymphocytic
populations was made through the use of monoclonal antibodies. The data obtained showed the following: levels of ADA were
significantly (p less than 0.0005) higher in the pleural fluid and the serum of tuberculous effusions compared to neoplastic
effusions; percentages of CD3 and CD4 T-cells were significantly (p less than 0.05 and p less than 0.0005, respectively) greater
in tuberculous effusions. The statistical study of the levels of ADA activity and the percentage of CD4 T-cells in pleural
exudates produced a significant regression curve (r = 0.612 and p less than 0.0001) which showed a positive correlation between
these two parameters. The pathogenic implications of these results suggest the possibility that ADA could be a new marker
of cell-mediated immune activity.</abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><pmid>1689629</pmid><doi>10.1378/chest.97.3.605</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenosine Deaminase - analysis Adenosine Deaminase - blood Adolescent Adult Aged Aged, 80 and over B-Lymphocytes - pathology Biological and medical sciences Child Epitopes Female Humans Leukocyte Count Male Medical sciences Middle Aged Nucleoside Deaminases - blood Pleural Effusion - enzymology Pleural Effusion - pathology Pleural Neoplasms - enzymology Pleural Neoplasms - pathology Pneumology T-Lymphocytes - immunology T-Lymphocytes - pathology T-Lymphocytes, Helper-Inducer - pathology T-Lymphocytes, Regulatory - pathology Tuberculosis, Pleural - enzymology Tuberculosis, Pleural - pathology |
| title | Serum and pleural adenosine deaminase. Correlation with lymphocytic populations |
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