Inhibitory effect of a new α-glucosidase inhibitor on fatty liver in Zucker fatty rats
The livers of Zucker fatty (fa/fa) and lean (Fa/−) rats treated with standard rat chow diet containing 0, 10 or 50 ppm α-glucosidase inhibitor (AO-128) for 10 weeks were studied morphologically and biochemically. Light microscopic examination of livers from untreated Zucker fatty rats showed severe...
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| Veröffentlicht in: | Journal of hepatology 1990, Vol.10 (1), p.62-68 |
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| container_title | Journal of hepatology |
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| creator | Inui, Yoshiaki Kawata, Sumio Matsuzawa, Yuji Tokunaga, Katsuto Fujioka, Shigenori Tamura, Shinji Kobatake, Takashi Kenoxa, Yoshiaki Odaka, Hiroyuki Matsuo, Takao Tarui, Seiichiro |
| description | The livers of Zucker fatty (fa/fa) and lean (Fa/−) rats treated with standard rat chow diet containing 0, 10 or 50 ppm α-glucosidase inhibitor (AO-128) for 10 weeks were studied morphologically and biochemically. Light microscopic examination of livers from untreated Zucker fatty rats showed severe steatosis. The triglyceride content in the livers from Zucker fatty rats was significantly higher than that from lean rats (73 ± 9 μg/mg protein for Zucker fatty rats vs. 30 ± 10 for lean rats,
p < 0.01). Administration of the inhibitor caused a marked decrease in the number and size of lipid droplets in the hepatocytes from Zucker fatty rats and a decrease in the triglyceride content in the liver (73 ± 9 μg/mg protein for untreated, 54 ±16 for 10-ppm-treated and 48 ± 23 for 50-ppm-treated rats,
p < 0.05). This is the first report showing an inhibitory effect of an α-glucosidase inhibitor on steatosis in Zucker fatty rats. |
| doi_str_mv | 10.1016/0168-8278(90)90074-2 |
| format | Article |
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p < 0.01). Administration of the inhibitor caused a marked decrease in the number and size of lipid droplets in the hepatocytes from Zucker fatty rats and a decrease in the triglyceride content in the liver (73 ± 9 μg/mg protein for untreated, 54 ±16 for 10-ppm-treated and 48 ± 23 for 50-ppm-treated rats,
p < 0.05). This is the first report showing an inhibitory effect of an α-glucosidase inhibitor on steatosis in Zucker fatty rats.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/0168-8278(90)90074-2</identifier><identifier>PMID: 2407772</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cyclohexanols - pharmacology ; Digestive system ; Fatty Liver - metabolism ; Fatty Liver - pathology ; Female ; Glycoside Hydrolase Inhibitors ; Lipid Metabolism ; Liver - metabolism ; Liver - pathology ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Zucker ; Reference Values</subject><ispartof>Journal of hepatology, 1990, Vol.10 (1), p.62-68</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-c3acc9373a1bf808861ca775939c1c13d65b1c4fba9077130bfcbc6f2745b9903</citedby><cites>FETCH-LOGICAL-c386t-c3acc9373a1bf808861ca775939c1c13d65b1c4fba9077130bfcbc6f2745b9903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0168827890900742$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6826011$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2407772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inui, Yoshiaki</creatorcontrib><creatorcontrib>Kawata, Sumio</creatorcontrib><creatorcontrib>Matsuzawa, Yuji</creatorcontrib><creatorcontrib>Tokunaga, Katsuto</creatorcontrib><creatorcontrib>Fujioka, Shigenori</creatorcontrib><creatorcontrib>Tamura, Shinji</creatorcontrib><creatorcontrib>Kobatake, Takashi</creatorcontrib><creatorcontrib>Kenoxa, Yoshiaki</creatorcontrib><creatorcontrib>Odaka, Hiroyuki</creatorcontrib><creatorcontrib>Matsuo, Takao</creatorcontrib><creatorcontrib>Tarui, Seiichiro</creatorcontrib><title>Inhibitory effect of a new α-glucosidase inhibitor on fatty liver in Zucker fatty rats</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>The livers of Zucker fatty (fa/fa) and lean (Fa/−) rats treated with standard rat chow diet containing 0, 10 or 50 ppm α-glucosidase inhibitor (AO-128) for 10 weeks were studied morphologically and biochemically. Light microscopic examination of livers from untreated Zucker fatty rats showed severe steatosis. The triglyceride content in the livers from Zucker fatty rats was significantly higher than that from lean rats (73 ± 9 μg/mg protein for Zucker fatty rats vs. 30 ± 10 for lean rats,
p < 0.01). Administration of the inhibitor caused a marked decrease in the number and size of lipid droplets in the hepatocytes from Zucker fatty rats and a decrease in the triglyceride content in the liver (73 ± 9 μg/mg protein for untreated, 54 ±16 for 10-ppm-treated and 48 ± 23 for 50-ppm-treated rats,
p < 0.05). This is the first report showing an inhibitory effect of an α-glucosidase inhibitor on steatosis in Zucker fatty rats.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cyclohexanols - pharmacology</subject><subject>Digestive system</subject><subject>Fatty Liver - metabolism</subject><subject>Fatty Liver - pathology</subject><subject>Female</subject><subject>Glycoside Hydrolase Inhibitors</subject><subject>Lipid Metabolism</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Reference Values</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMo4zj6BgpZiOiietJ2kmYjyOANBDeK4Cakp4lGO60mrTKP5Yv4TGaccZYuciH_d04OHyG7DI4ZMH4SV5EUqSgOJRxJAJEn6RoZMg6QAM_ZOhmukE2yFcILAGQg8wEZpDkIIdIhebhunl3putbPqLHWYEdbSzVtzCf9_kqe6h7b4CodDHV_JG0banXXzWjtPoyPAX3s8TXeFq9ed2GbbFhdB7OzPEfk_uL8bnKV3NxeXk_ObhLMCt7FXSPKTGSalbaAouAMtRBjmUlkyLKKj0uGuS21jAOzDEqLJXKbinxcSgnZiBws-r759r03oVNTF9DUtW5M2wclJB-nUUYE8wWIvg3BG6vevJtqP1MM1NynmstSc1lKgvr1qdJYtrfs35dTU62KlgJjvr_MdUBdW68bdGGF8SLlwOa_ny4wE118OONVQGcaNJXz0bmqWvf_HD-GKJGy</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Inui, Yoshiaki</creator><creator>Kawata, Sumio</creator><creator>Matsuzawa, Yuji</creator><creator>Tokunaga, Katsuto</creator><creator>Fujioka, Shigenori</creator><creator>Tamura, Shinji</creator><creator>Kobatake, Takashi</creator><creator>Kenoxa, Yoshiaki</creator><creator>Odaka, Hiroyuki</creator><creator>Matsuo, Takao</creator><creator>Tarui, Seiichiro</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Inhibitory effect of a new α-glucosidase inhibitor on fatty liver in Zucker fatty rats</title><author>Inui, Yoshiaki ; Kawata, Sumio ; Matsuzawa, Yuji ; Tokunaga, Katsuto ; Fujioka, Shigenori ; Tamura, Shinji ; Kobatake, Takashi ; Kenoxa, Yoshiaki ; Odaka, Hiroyuki ; Matsuo, Takao ; Tarui, Seiichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-c3acc9373a1bf808861ca775939c1c13d65b1c4fba9077130bfcbc6f2745b9903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclohexanols - pharmacology</topic><topic>Digestive system</topic><topic>Fatty Liver - metabolism</topic><topic>Fatty Liver - pathology</topic><topic>Female</topic><topic>Glycoside Hydrolase Inhibitors</topic><topic>Lipid Metabolism</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inui, Yoshiaki</creatorcontrib><creatorcontrib>Kawata, Sumio</creatorcontrib><creatorcontrib>Matsuzawa, Yuji</creatorcontrib><creatorcontrib>Tokunaga, Katsuto</creatorcontrib><creatorcontrib>Fujioka, Shigenori</creatorcontrib><creatorcontrib>Tamura, Shinji</creatorcontrib><creatorcontrib>Kobatake, Takashi</creatorcontrib><creatorcontrib>Kenoxa, Yoshiaki</creatorcontrib><creatorcontrib>Odaka, Hiroyuki</creatorcontrib><creatorcontrib>Matsuo, Takao</creatorcontrib><creatorcontrib>Tarui, Seiichiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inui, Yoshiaki</au><au>Kawata, Sumio</au><au>Matsuzawa, Yuji</au><au>Tokunaga, Katsuto</au><au>Fujioka, Shigenori</au><au>Tamura, Shinji</au><au>Kobatake, Takashi</au><au>Kenoxa, Yoshiaki</au><au>Odaka, Hiroyuki</au><au>Matsuo, Takao</au><au>Tarui, Seiichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effect of a new α-glucosidase inhibitor on fatty liver in Zucker fatty rats</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>1990</date><risdate>1990</risdate><volume>10</volume><issue>1</issue><spage>62</spage><epage>68</epage><pages>62-68</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>The livers of Zucker fatty (fa/fa) and lean (Fa/−) rats treated with standard rat chow diet containing 0, 10 or 50 ppm α-glucosidase inhibitor (AO-128) for 10 weeks were studied morphologically and biochemically. Light microscopic examination of livers from untreated Zucker fatty rats showed severe steatosis. The triglyceride content in the livers from Zucker fatty rats was significantly higher than that from lean rats (73 ± 9 μg/mg protein for Zucker fatty rats vs. 30 ± 10 for lean rats,
p < 0.01). Administration of the inhibitor caused a marked decrease in the number and size of lipid droplets in the hepatocytes from Zucker fatty rats and a decrease in the triglyceride content in the liver (73 ± 9 μg/mg protein for untreated, 54 ±16 for 10-ppm-treated and 48 ± 23 for 50-ppm-treated rats,
p < 0.05). This is the first report showing an inhibitory effect of an α-glucosidase inhibitor on steatosis in Zucker fatty rats.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>2407772</pmid><doi>10.1016/0168-8278(90)90074-2</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of hepatology, 1990, Vol.10 (1), p.62-68 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cyclohexanols - pharmacology Digestive system Fatty Liver - metabolism Fatty Liver - pathology Female Glycoside Hydrolase Inhibitors Lipid Metabolism Liver - metabolism Liver - pathology Medical sciences Pharmacology. Drug treatments Rats Rats, Zucker Reference Values |
| title | Inhibitory effect of a new α-glucosidase inhibitor on fatty liver in Zucker fatty rats |
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