Bradycardia and syncope as manifestations of partial epilepsy
Although transient increases in heart rate typically occur, bradycardia has infrequently been noted in association with partial seizures. Five patients with temporal lobe epilepsy are described in whom sinus bradyarrhythmias and syncope were prominent manifestations of seizure activity. Partial impr...
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| Veröffentlicht in: | Journal of the American College of Cardiology 1990-03, Vol.15 (4), p.900-905 |
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| container_title | Journal of the American College of Cardiology |
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| creator | Constantin, Luis Martins, James B. Fincham, Richard W. Dagli, Rajesh D. |
| description | Although transient increases in heart rate typically occur, bradycardia has infrequently been noted in association with partial seizures. Five patients with temporal lobe epilepsy are described in whom sinus bradyarrhythmias and syncope were prominent manifestations of seizure activity. Partial improvement occurred in one of two patients in whom a permanent pacemaker was implanted before a diagnosis of epilepsy was established. Treatment with phenytoin or carbamazepine resulted in nearly complete resolution of symptoms in all five patients.
Because pacemaker implantation does not prevent recurrent symptoms, but anticonvulsant therapy does, this experience underscores the importance of considering the diagnosis of partial epilepsy in selected patients with sinus bradyarrhythmias and syncope. |
| doi_str_mv | 10.1016/0735-1097(90)90290-6 |
| format | Article |
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Because pacemaker implantation does not prevent recurrent symptoms, but anticonvulsant therapy does, this experience underscores the importance of considering the diagnosis of partial epilepsy in selected patients with sinus bradyarrhythmias and syncope.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/0735-1097(90)90290-6</identifier><identifier>PMID: 2307800</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Bradycardia - etiology ; Bradycardia - therapy ; Carbamazepine - therapeutic use ; Electrocardiography ; Electroencephalography ; Epilepsy, Temporal Lobe - complications ; Epilepsy, Temporal Lobe - drug therapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pacemaker, Artificial ; Pharmacology. Drug treatments ; Phenytoin - therapeutic use ; Syncope - etiology</subject><ispartof>Journal of the American College of Cardiology, 1990-03, Vol.15 (4), p.900-905</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-c60d72d68fdf3e1c04d3a195af1191a6df51e8bf32ae4c61f98a0638296e5a053</citedby><cites>FETCH-LOGICAL-c533t-c60d72d68fdf3e1c04d3a195af1191a6df51e8bf32ae4c61f98a0638296e5a053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0735-1097(90)90290-6$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19305117$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2307800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Constantin, Luis</creatorcontrib><creatorcontrib>Martins, James B.</creatorcontrib><creatorcontrib>Fincham, Richard W.</creatorcontrib><creatorcontrib>Dagli, Rajesh D.</creatorcontrib><title>Bradycardia and syncope as manifestations of partial epilepsy</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Although transient increases in heart rate typically occur, bradycardia has infrequently been noted in association with partial seizures. Five patients with temporal lobe epilepsy are described in whom sinus bradyarrhythmias and syncope were prominent manifestations of seizure activity. Partial improvement occurred in one of two patients in whom a permanent pacemaker was implanted before a diagnosis of epilepsy was established. Treatment with phenytoin or carbamazepine resulted in nearly complete resolution of symptoms in all five patients.
Because pacemaker implantation does not prevent recurrent symptoms, but anticonvulsant therapy does, this experience underscores the importance of considering the diagnosis of partial epilepsy in selected patients with sinus bradyarrhythmias and syncope.</description><subject>Adult</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Bradycardia - etiology</subject><subject>Bradycardia - therapy</subject><subject>Carbamazepine - therapeutic use</subject><subject>Electrocardiography</subject><subject>Electroencephalography</subject><subject>Epilepsy, Temporal Lobe - complications</subject><subject>Epilepsy, Temporal Lobe - drug therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pacemaker, Artificial</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenytoin - therapeutic use</subject><subject>Syncope - etiology</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LJDEQhoO46PjxDxT64qKHXqs6k3TnoLCK7i4IXvQcyqQCkZ7uNulZmH9vjzPozVMd3ud9KR4hThB-IaC-hFqqEsHU5wYuDFQGSr0jZqhUU0pl6l0x-0T2xUHOrwCgGzR7Yq-SUDcAM3F1k8ivHCUfqaDOF3nVuX7ggnKxoC4GziONse9y0YdioDRGagseYstDXh2JH4HazMfbeyie7--ebv-WD49__t3-fiidknIsnQZfV143wQfJ6GDuJaFRFBANkvZBITcvQVbEc6cxmIZAy6YymhWBkofi52Z3SP3bcnrJLmJ23LbUcb_MtjZaVXOJEzjfgC71OScOdkhxQWllEezaml0rsWsl1oD9sGb1VDvd7i9fFuw_S1tNU362zSk7akOizsX8tW0kKMR64q43HE8y_kdONrvInWMfE7vR-j5-_8g7CNiINA</recordid><startdate>19900315</startdate><enddate>19900315</enddate><creator>Constantin, Luis</creator><creator>Martins, James B.</creator><creator>Fincham, Richard W.</creator><creator>Dagli, Rajesh D.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900315</creationdate><title>Bradycardia and syncope as manifestations of partial epilepsy</title><author>Constantin, Luis ; Martins, James B. ; Fincham, Richard W. ; Dagli, Rajesh D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-c60d72d68fdf3e1c04d3a195af1191a6df51e8bf32ae4c61f98a0638296e5a053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Bradycardia - etiology</topic><topic>Bradycardia - therapy</topic><topic>Carbamazepine - therapeutic use</topic><topic>Electrocardiography</topic><topic>Electroencephalography</topic><topic>Epilepsy, Temporal Lobe - complications</topic><topic>Epilepsy, Temporal Lobe - drug therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pacemaker, Artificial</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenytoin - therapeutic use</topic><topic>Syncope - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Constantin, Luis</creatorcontrib><creatorcontrib>Martins, James B.</creatorcontrib><creatorcontrib>Fincham, Richard W.</creatorcontrib><creatorcontrib>Dagli, Rajesh D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Constantin, Luis</au><au>Martins, James B.</au><au>Fincham, Richard W.</au><au>Dagli, Rajesh D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bradycardia and syncope as manifestations of partial epilepsy</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1990-03-15</date><risdate>1990</risdate><volume>15</volume><issue>4</issue><spage>900</spage><epage>905</epage><pages>900-905</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Although transient increases in heart rate typically occur, bradycardia has infrequently been noted in association with partial seizures. Five patients with temporal lobe epilepsy are described in whom sinus bradyarrhythmias and syncope were prominent manifestations of seizure activity. Partial improvement occurred in one of two patients in whom a permanent pacemaker was implanted before a diagnosis of epilepsy was established. Treatment with phenytoin or carbamazepine resulted in nearly complete resolution of symptoms in all five patients.
Because pacemaker implantation does not prevent recurrent symptoms, but anticonvulsant therapy does, this experience underscores the importance of considering the diagnosis of partial epilepsy in selected patients with sinus bradyarrhythmias and syncope.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2307800</pmid><doi>10.1016/0735-1097(90)90290-6</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American College of Cardiology, 1990-03, Vol.15 (4), p.900-905 |
| issn | 0735-1097 1558-3597 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Bradycardia - etiology Bradycardia - therapy Carbamazepine - therapeutic use Electrocardiography Electroencephalography Epilepsy, Temporal Lobe - complications Epilepsy, Temporal Lobe - drug therapy Humans Male Medical sciences Middle Aged Neuropharmacology Pacemaker, Artificial Pharmacology. Drug treatments Phenytoin - therapeutic use Syncope - etiology |
| title | Bradycardia and syncope as manifestations of partial epilepsy |
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