HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses
AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybrid...
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| Veröffentlicht in: | The Lancet (British edition) 1990-03, Vol.335 (8689), p.565-568 |
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| container_title | The Lancet (British edition) |
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| creator | Lewis, S.H. Fox, H.E. Lewis, S.H. Lewis, S.H. Reynolds-Kohler, C. Nelson, J.A. |
| description | AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age. |
| doi_str_mv | 10.1016/0140-6736(90)90349-A |
| format | Article |
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Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(90)90349-A</identifier><identifier>PMID: 1689792</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; AIDS/HIV ; Antibodies, Monoclonal ; Biological and medical sciences ; Blood cells ; Children ; Chorionic Villi - analysis ; Decidua ; Disease transmission ; Endothelium, Vascular - pathology ; Enzyme-linked immunosorbent assay ; Erythroid Precursor Cells - analysis ; Female ; Fetuses ; Gestational age ; Hemopoiesis ; HIV ; HIV Antigens - analysis ; HIV Envelope Protein gp41 - analysis ; HIV Seropositivity - immunology ; HIV-1 - immunology ; Human immunodeficiency virus ; Humans ; Hybridization ; Immunocytochemistry ; Immunopathology ; Leukocytes ; Leukocytes - analysis ; Macrophages - analysis ; Medical sciences ; Mesenchyme ; Nucleic acids ; Placenta ; Placenta - analysis ; Precursors ; Pregnancy ; Pregnancy Trimester, First ; Staining and Labeling ; Tests ; Trophoblasts - analysis ; Viruses</subject><ispartof>The Lancet (British edition), 1990-03, Vol.335 (8689), p.565-568</ispartof><rights>1990</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Lancet Ltd. 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Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Blood cells</subject><subject>Children</subject><subject>Chorionic Villi - analysis</subject><subject>Decidua</subject><subject>Disease transmission</subject><subject>Endothelium, Vascular - pathology</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Erythroid Precursor Cells - analysis</subject><subject>Female</subject><subject>Fetuses</subject><subject>Gestational age</subject><subject>Hemopoiesis</subject><subject>HIV</subject><subject>HIV Antigens - analysis</subject><subject>HIV Envelope Protein gp41 - analysis</subject><subject>HIV Seropositivity - immunology</subject><subject>HIV-1 - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hybridization</subject><subject>Immunocytochemistry</subject><subject>Immunopathology</subject><subject>Leukocytes</subject><subject>Leukocytes - analysis</subject><subject>Macrophages - analysis</subject><subject>Medical sciences</subject><subject>Mesenchyme</subject><subject>Nucleic acids</subject><subject>Placenta</subject><subject>Placenta - analysis</subject><subject>Precursors</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Staining and Labeling</subject><subject>Tests</subject><subject>Trophoblasts - analysis</subject><subject>Viruses</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFrFDEUhYModa3-A4VBi1hwNNlkkrkvhaWoWyj4ouJbyCQ33dTZyZrMVPz3ZrpLBaE-5eF89-Tcewh5zug7Rpl8T5mgtVRcvgF6CpQLqFcPyIIJJepGqO8PyeIOeUye5HxNKRWSNkfkiMkWFCwXxK8vvtWsCkM1prjbxK43eQy2MoOrbkLfxylX6-g7M2GqLPZ9fnurbQxuzRj7eBWs6atdQjulHFOerTBcbcb6F-KPyuM4ZcxPySNv-ozPDu8x-frxw5fzdX35-dPF-eqytoIuTQ1dC7KRQEXrGXpobNc67tEJBlSBF4IzY4x1qkMrHSwddAqwk0KA4NzxY_J677tL8eeEedTbkOfYZsCyilYgBUArC_jqH_A6Tmko2fSSNVIUTLWFenkfxaCFlsuGFUjsIZtizgm93qWwNem3ZlTPTem5Bj3XoIHq26b0qoy9OHhP3Rbd36F9NUU_OegmlxP7ZAYb8h0mJJMc5t_P9hiWs94ETDrbgINFF0ono3Yx_D_HH0k_rnU</recordid><startdate>19900310</startdate><enddate>19900310</enddate><creator>Lewis, S.H.</creator><creator>Fox, H.E.</creator><creator>Lewis, S.H.</creator><creator>Lewis, S.H.</creator><creator>Reynolds-Kohler, C.</creator><creator>Nelson, J.A.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19900310</creationdate><title>HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses</title><author>Lewis, S.H. ; Fox, H.E. ; Lewis, S.H. ; Lewis, S.H. ; Reynolds-Kohler, C. ; Nelson, J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402a-9b896569048f1ef95cb8d3fed419079f4431aaacd7bec6d92d9b79eb6449433d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Blood cells</topic><topic>Children</topic><topic>Chorionic Villi - analysis</topic><topic>Decidua</topic><topic>Disease transmission</topic><topic>Endothelium, Vascular - pathology</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Erythroid Precursor Cells - analysis</topic><topic>Female</topic><topic>Fetuses</topic><topic>Gestational age</topic><topic>Hemopoiesis</topic><topic>HIV</topic><topic>HIV Antigens - analysis</topic><topic>HIV Envelope Protein gp41 - analysis</topic><topic>HIV Seropositivity - immunology</topic><topic>HIV-1 - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Hybridization</topic><topic>Immunocytochemistry</topic><topic>Immunopathology</topic><topic>Leukocytes</topic><topic>Leukocytes - analysis</topic><topic>Macrophages - analysis</topic><topic>Medical sciences</topic><topic>Mesenchyme</topic><topic>Nucleic acids</topic><topic>Placenta</topic><topic>Placenta - analysis</topic><topic>Precursors</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Staining and Labeling</topic><topic>Tests</topic><topic>Trophoblasts - analysis</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lewis, S.H.</creatorcontrib><creatorcontrib>Fox, H.E.</creatorcontrib><creatorcontrib>Lewis, S.H.</creatorcontrib><creatorcontrib>Lewis, S.H.</creatorcontrib><creatorcontrib>Reynolds-Kohler, C.</creatorcontrib><creatorcontrib>Nelson, J.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lewis, S.H.</au><au>Fox, H.E.</au><au>Lewis, S.H.</au><au>Lewis, S.H.</au><au>Reynolds-Kohler, C.</au><au>Nelson, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1990-03-10</date><risdate>1990</risdate><volume>335</volume><issue>8689</issue><spage>565</spage><epage>568</epage><pages>565-568</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). 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| subjects | Acquired immune deficiency syndrome Adult AIDS AIDS/HIV Antibodies, Monoclonal Biological and medical sciences Blood cells Children Chorionic Villi - analysis Decidua Disease transmission Endothelium, Vascular - pathology Enzyme-linked immunosorbent assay Erythroid Precursor Cells - analysis Female Fetuses Gestational age Hemopoiesis HIV HIV Antigens - analysis HIV Envelope Protein gp41 - analysis HIV Seropositivity - immunology HIV-1 - immunology Human immunodeficiency virus Humans Hybridization Immunocytochemistry Immunopathology Leukocytes Leukocytes - analysis Macrophages - analysis Medical sciences Mesenchyme Nucleic acids Placenta Placenta - analysis Precursors Pregnancy Pregnancy Trimester, First Staining and Labeling Tests Trophoblasts - analysis Viruses |
| title | HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses |
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