Thyroid peroxidase gene promoter confers TSH responsiveness to heterologous reporter genes in transfection experiments

The cyclic AMP-mediated transcriptional regulation of the enzyme thyroperoxidase by thyrotropin (TSH) in thyroid follicular cells was examined at the molecular level. The 5′ end of the human thyroperoxidase gene was isolated and sequenced and the transcription start site was mapped by S1 nuclease an...

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Veröffentlicht in:	Biochemical and biophysical research communications 1990-02, Vol.166 (3), p.1257-1264
Hauptverfasser:	Abramowicz, Marc J., Vassart, Gilbert, Christophe, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cells, Cultured Chloramphenicol O-Acetyltransferase - genetics Cloning, Molecular Colforsin - pharmacology DNA - genetics Dogs Fundamental and applied biological sciences. Psychology Genes - drug effects Genome, Human Humans Iodide Peroxidase - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Oligonucleotide Probes Promoter Regions, Genetic - drug effects Restriction Mapping Thyroid Gland - enzymology Thyrotropin - pharmacology Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing Transfection
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