The Hyperthyroid Heart: An Analysis of Systolic and Diastolic Properties in Single Rat Ventricular Myocytes

Single ventricular myocytes were isolated by collagenase digestion from the hearts of 6–8-month-old male Wistar rats in either the control (euthyroid) state or after 7 days of daily injection of 0.64 mg/kg thyroxine (hyperthyroid). Myocytes were field-stimulated from slack length, and contraction wa...

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Veröffentlicht in:	Circulation research 1990-03, Vol.66 (3), p.773-781
Hauptverfasser:	Josephson, Richard A, Spurgeon, Harold A, Lakatta, Edward G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Cell Separation Diastole Electric Stimulation Endocrinopathies Heart - physiopathology Heart Ventricles Hyperthyroidism - pathology Hyperthyroidism - physiopathology Medical sciences Myocardial Contraction Myocardium - metabolism Myocardium - pathology Non tumoral diseases. Target tissue resistance. Benign neoplasms Ouabain - pharmacology Sarcoplasmic Reticulum - metabolism Systole Thyroid. Thyroid axis (diseases)
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