Low‐grade intraosseous osteosarcoma
A study of 80 well‐differentiated osteosarcomas, 16 from the Mayo Clinic files and 64 from our consultation files, revealed that males and females were about equally affected, most of the patients were young adults, and skeletal distribution was similar to the distribution seen in conventional osteo...
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| Veröffentlicht in: | Cancer 1990-03, Vol.65 (6), p.1418-1428 |
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| container_title | Cancer |
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| creator | Kurt, Anne‐Marie Unni, K. Krishnan McLeod, Richard A. Pritchard, Douglas J. |
| description | A study of 80 well‐differentiated osteosarcomas, 16 from the Mayo Clinic files and 64 from our consultation files, revealed that males and females were about equally affected, most of the patients were young adults, and skeletal distribution was similar to the distribution seen in conventional osteosarcoma. Radiographs generally showed poor margination, suggestive of malignancy. Histologically, the tumors were composed of spindle cells with only minimal atypia. Some tumors had bone spicules similar to those seen in fibrous dysplasia. An invasive growth pattern was the most helpful feature in differentiating low‐grade osteosarcoma from fibrous dysplasia. Initial treatment was highly variable. Local excision was almost always associated with recurrence. Wide excision was almost never followed by recurrence. The recurrent tumor was a high‐grade, conventional osteosarcoma in 15% of the patients, and this was associated with a poor prognosis. Wide excision seems to be the treatment of choice for this very rare variant of osteosarcoma. |
| doi_str_mv | 10.1002/1097-0142(19900315)65:6<1418::AID-CNCR2820650629>3.0.CO;2-Q |
| format | Article |
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Wide excision was almost never followed by recurrence. The recurrent tumor was a high‐grade, conventional osteosarcoma in 15% of the patients, and this was associated with a poor prognosis. Wide excision seems to be the treatment of choice for this very rare variant of osteosarcoma.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19900315)65:6<1418::AID-CNCR2820650629>3.0.CO;2-Q</identifier><identifier>PMID: 2306687</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - pathology ; Bone Neoplasms - surgery ; Child ; Diseases of the osteoarticular system ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Osteosarcoma - diagnostic imaging ; Osteosarcoma - pathology ; Osteosarcoma - surgery ; Tomography, X-Ray Computed ; Tumors of striated muscle and skeleton</subject><ispartof>Cancer, 1990-03, Vol.65 (6), p.1418-1428</ispartof><rights>Copyright © 1990 American Cancer Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4999-6ec4557dac58c56e0a8006fa9be0456d6829241ef0d6060e32e29c5f98c5299c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19505175$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2306687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurt, Anne‐Marie</creatorcontrib><creatorcontrib>Unni, K. Krishnan</creatorcontrib><creatorcontrib>McLeod, Richard A.</creatorcontrib><creatorcontrib>Pritchard, Douglas J.</creatorcontrib><title>Low‐grade intraosseous osteosarcoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A study of 80 well‐differentiated osteosarcomas, 16 from the Mayo Clinic files and 64 from our consultation files, revealed that males and females were about equally affected, most of the patients were young adults, and skeletal distribution was similar to the distribution seen in conventional osteosarcoma. Radiographs generally showed poor margination, suggestive of malignancy. Histologically, the tumors were composed of spindle cells with only minimal atypia. Some tumors had bone spicules similar to those seen in fibrous dysplasia. An invasive growth pattern was the most helpful feature in differentiating low‐grade osteosarcoma from fibrous dysplasia. Initial treatment was highly variable. Local excision was almost always associated with recurrence. Wide excision was almost never followed by recurrence. The recurrent tumor was a high‐grade, conventional osteosarcoma in 15% of the patients, and this was associated with a poor prognosis. Wide excision seems to be the treatment of choice for this very rare variant of osteosarcoma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Neoplasms - surgery</subject><subject>Child</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteosarcoma - diagnostic imaging</subject><subject>Osteosarcoma - pathology</subject><subject>Osteosarcoma - surgery</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkN1KwzAYhoMoOqeXIHii6EHnl6RJmymC1F8YDkVB8OAjpqlUunUmG7IzL8Fr9EpM2VT0QBACIbxvXh4eQjIKHQrA9iioJAIasx2qFACnYleKrjygMU273aOL4yi7zK5ZykAKkEwd8g50sv4-i64WSOvr9yJpAUAaiZjfrZBV75_CM2GCL5NlxkHKNGmRrV798v769uh0bjfL4djp2ntbT_xm7ce29tqZeqDXyFKhK2_X53eb3J6e3GTnUa9_dpEd9SITK6UiaU0sRJJrI1IjpAWdAshCqwcLsZC5TJliMbUF5BIkWM4sU0YUKrSZUoa3yfZsd-Tq54n1YxyU3tiq0sOGCRMluRIxC8X7WdG4wOtsgSNXDrSbIgVsJGKjARsN-CkRZTjYSEQMEvGnROQImPWR4VVY35hjTB4GNv_anlsL-dY8197oqnB6aEr_jaAECJqI0CtmvZeystP_If5J-CvhH6Ujm3o</recordid><startdate>19900315</startdate><enddate>19900315</enddate><creator>Kurt, Anne‐Marie</creator><creator>Unni, K. 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Krishnan ; McLeod, Richard A. ; Pritchard, Douglas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4999-6ec4557dac58c56e0a8006fa9be0456d6829241ef0d6060e32e29c5f98c5299c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Neoplasms - surgery</topic><topic>Child</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteosarcoma - diagnostic imaging</topic><topic>Osteosarcoma - pathology</topic><topic>Osteosarcoma - surgery</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurt, Anne‐Marie</creatorcontrib><creatorcontrib>Unni, K. Krishnan</creatorcontrib><creatorcontrib>McLeod, Richard A.</creatorcontrib><creatorcontrib>Pritchard, Douglas J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurt, Anne‐Marie</au><au>Unni, K. Krishnan</au><au>McLeod, Richard A.</au><au>Pritchard, Douglas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low‐grade intraosseous osteosarcoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1990-03-15</date><risdate>1990</risdate><volume>65</volume><issue>6</issue><spage>1418</spage><epage>1428</epage><pages>1418-1428</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>A study of 80 well‐differentiated osteosarcomas, 16 from the Mayo Clinic files and 64 from our consultation files, revealed that males and females were about equally affected, most of the patients were young adults, and skeletal distribution was similar to the distribution seen in conventional osteosarcoma. Radiographs generally showed poor margination, suggestive of malignancy. Histologically, the tumors were composed of spindle cells with only minimal atypia. Some tumors had bone spicules similar to those seen in fibrous dysplasia. An invasive growth pattern was the most helpful feature in differentiating low‐grade osteosarcoma from fibrous dysplasia. Initial treatment was highly variable. Local excision was almost always associated with recurrence. Wide excision was almost never followed by recurrence. The recurrent tumor was a high‐grade, conventional osteosarcoma in 15% of the patients, and this was associated with a poor prognosis. Wide excision seems to be the treatment of choice for this very rare variant of osteosarcoma.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2306687</pmid><doi>10.1002/1097-0142(19900315)65:6<1418::AID-CNCR2820650629>3.0.CO;2-Q</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Bone Neoplasms - diagnostic imaging Bone Neoplasms - pathology Bone Neoplasms - surgery Child Diseases of the osteoarticular system Female Follow-Up Studies Humans Magnetic Resonance Imaging Male Medical sciences Middle Aged Osteosarcoma - diagnostic imaging Osteosarcoma - pathology Osteosarcoma - surgery Tomography, X-Ray Computed Tumors of striated muscle and skeleton |
| title | Low‐grade intraosseous osteosarcoma |
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