The Renin-Angiotensin System in Different Stages of Spontaneous Hypertension in the Rat (S H R)
The present study analyzed the concentration of renin-like activity and angiotensinogen concentration (AoC) in different brain areas related to cardiovascular control in SHR and Wistar Kyoto (WKY) animals. Male rats of both strains were studied at 8, 16 and 30 weeks of age. The following brain areas...
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| Veröffentlicht in: | Clinical and experimental hypertension (1993) 1990, Vol.A12 (1), p.63-81 |
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| container_title | Clinical and experimental hypertension (1993) |
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| creator | Ruiz, Patricia Basso, Nidia Cannata, Miguel Angel Taquini, Alberto C. |
| description | The present study analyzed the concentration of renin-like activity and angiotensinogen concentration (AoC) in different brain areas related to cardiovascular control in SHR and Wistar Kyoto (WKY) animals. Male rats of both strains were studied at 8, 16 and 30 weeks of age. The following brain areas were isolated: anterior, medial and posterior hypothalamus, septal area, peri-aqueductal gray (PG) and the remaining brain stem; nucleus tractus solitarius (NTS) and the remaining medulla oblongata. Plasma renin activity (PRA) and plasma and cerebrospinal fluid (CSF) AoC were determined. Renin-like concentration was higher in SHR than in WKY in the anterior hypothalamus, PG and NTS at different stages of hypertension development. AoC was also higher in some areas of the SHR brain during different periods. PRA, plasma and CSF angiotensinogen concentration showed significant differences between both strain of rats during the development of high blood pressure. Present data support the possibility that the central and peripheral renin-angiotensin system may participate in the maintenance of high blood pressure in the SHR animals. |
| doi_str_mv | 10.3109/10641969009074720 |
| format | Article |
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Male rats of both strains were studied at 8, 16 and 30 weeks of age. The following brain areas were isolated: anterior, medial and posterior hypothalamus, septal area, peri-aqueductal gray (PG) and the remaining brain stem; nucleus tractus solitarius (NTS) and the remaining medulla oblongata. Plasma renin activity (PRA) and plasma and cerebrospinal fluid (CSF) AoC were determined. Renin-like concentration was higher in SHR than in WKY in the anterior hypothalamus, PG and NTS at different stages of hypertension development. AoC was also higher in some areas of the SHR brain during different periods. PRA, plasma and CSF angiotensinogen concentration showed significant differences between both strain of rats during the development of high blood pressure. Present data support the possibility that the central and peripheral renin-angiotensin system may participate in the maintenance of high blood pressure in the SHR animals.</description><identifier>ISSN: 1064-1963</identifier><identifier>ISSN: 0730-0077</identifier><identifier>EISSN: 1525-6006</identifier><identifier>DOI: 10.3109/10641969009074720</identifier><identifier>PMID: 2407392</identifier><identifier>CODEN: CEHADM</identifier><language>eng</language><publisher>Basel: Informa UK Ltd</publisher><subject>Age ; Age Factors ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Angiotensinogen - analysis ; Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Brain Chemistry ; Brain localization ; Cardiology. Vascular system ; Experimental diseases ; Hypertension - physiopathology ; Male ; Medical sciences ; Protein Precursors - analysis ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Renin - analysis ; Renin-Angiotensin ; Renin-Angiotensin System - physiology ; Spontaneously hypertensive rats (SHR)</subject><ispartof>Clinical and experimental hypertension (1993), 1990, Vol.A12 (1), p.63-81</ispartof><rights>1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-cd8a4f1865b112045e2fd18f5aee0e759ee9470c72d3cb6e8d5fba7ada6a2b253</citedby><cites>FETCH-LOGICAL-c431t-cd8a4f1865b112045e2fd18f5aee0e759ee9470c72d3cb6e8d5fba7ada6a2b253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10641969009074720$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10641969009074720$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,59624,60413,61198,61379</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19576426$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2407392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz, Patricia</creatorcontrib><creatorcontrib>Basso, Nidia</creatorcontrib><creatorcontrib>Cannata, Miguel Angel</creatorcontrib><creatorcontrib>Taquini, Alberto C.</creatorcontrib><title>The Renin-Angiotensin System in Different Stages of Spontaneous Hypertension in the Rat (S H R)</title><title>Clinical and experimental hypertension (1993)</title><addtitle>Clin Exp Hypertens A</addtitle><description>The present study analyzed the concentration of renin-like activity and angiotensinogen concentration (AoC) in different brain areas related to cardiovascular control in SHR and Wistar Kyoto (WKY) animals. Male rats of both strains were studied at 8, 16 and 30 weeks of age. The following brain areas were isolated: anterior, medial and posterior hypothalamus, septal area, peri-aqueductal gray (PG) and the remaining brain stem; nucleus tractus solitarius (NTS) and the remaining medulla oblongata. Plasma renin activity (PRA) and plasma and cerebrospinal fluid (CSF) AoC were determined. Renin-like concentration was higher in SHR than in WKY in the anterior hypothalamus, PG and NTS at different stages of hypertension development. AoC was also higher in some areas of the SHR brain during different periods. PRA, plasma and CSF angiotensinogen concentration showed significant differences between both strain of rats during the development of high blood pressure. Present data support the possibility that the central and peripheral renin-angiotensin system may participate in the maintenance of high blood pressure in the SHR animals.</description><subject>Age</subject><subject>Age Factors</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Angiotensinogen - analysis</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Brain Chemistry</subject><subject>Brain localization</subject><subject>Cardiology. Vascular system</subject><subject>Experimental diseases</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Protein Precursors - analysis</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Renin - analysis</subject><subject>Renin-Angiotensin</subject><subject>Renin-Angiotensin System - physiology</subject><subject>Spontaneously hypertensive rats (SHR)</subject><issn>1064-1963</issn><issn>0730-0077</issn><issn>1525-6006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1rFDEUxYNYaq3-AT4IeVH0YTTJ5GOCvpT6sYWC0K3PIZO56U6ZSbZJFtn_3mx3VaTQp3vh_M7h3oPQK0o-tJToj5RITrXUhGiiuGLkCTqhgolGEiKf1r3qTQXaZ-h5zreEUC5Fd4yOGSeq1ewEmesV4CsIY2jOws0YC4Q8Brzc5gIzrtuX0XtIEApeFnsDGUePl-sYig0QNxkvtmtI964YdnzZ5dmC3y3xAl-9f4GOvJ0yvDzMU_Tz29fr80Vz-eP7xfnZZeN4S0vjhs5yTzspekoZ4QKYH2jnhQUgoIQG0FwRp9jQul5CNwjfW2UHKy3rmWhP0dt97jrFuw3kYuYxO5im_ZlG1RI0Z6SCdA-6FHNO4M06jbNNW0OJ2ZVqHpRaPa8P4Zt-huGv49Bi1d8cdJudnXyywY35X7AWSnImK_d5z43BxzTbXzFNgyl2O8X0x9Q-dsan_-wrsFNZOZvA3MZNCrXfR574DexRo6Y</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Ruiz, Patricia</creator><creator>Basso, Nidia</creator><creator>Cannata, Miguel Angel</creator><creator>Taquini, Alberto C.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>The Renin-Angiotensin System in Different Stages of Spontaneous Hypertension in the Rat (S H R)</title><author>Ruiz, Patricia ; Basso, Nidia ; Cannata, Miguel Angel ; Taquini, Alberto C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-cd8a4f1865b112045e2fd18f5aee0e759ee9470c72d3cb6e8d5fba7ada6a2b253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Angiotensinogen - analysis</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Brain Chemistry</topic><topic>Brain localization</topic><topic>Cardiology. Vascular system</topic><topic>Experimental diseases</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Protein Precursors - analysis</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Renin - analysis</topic><topic>Renin-Angiotensin</topic><topic>Renin-Angiotensin System - physiology</topic><topic>Spontaneously hypertensive rats (SHR)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz, Patricia</creatorcontrib><creatorcontrib>Basso, Nidia</creatorcontrib><creatorcontrib>Cannata, Miguel Angel</creatorcontrib><creatorcontrib>Taquini, Alberto C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental hypertension (1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz, Patricia</au><au>Basso, Nidia</au><au>Cannata, Miguel Angel</au><au>Taquini, Alberto C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Renin-Angiotensin System in Different Stages of Spontaneous Hypertension in the Rat (S H R)</atitle><jtitle>Clinical and experimental hypertension (1993)</jtitle><addtitle>Clin Exp Hypertens A</addtitle><date>1990</date><risdate>1990</risdate><volume>A12</volume><issue>1</issue><spage>63</spage><epage>81</epage><pages>63-81</pages><issn>1064-1963</issn><issn>0730-0077</issn><eissn>1525-6006</eissn><coden>CEHADM</coden><abstract>The present study analyzed the concentration of renin-like activity and angiotensinogen concentration (AoC) in different brain areas related to cardiovascular control in SHR and Wistar Kyoto (WKY) animals. Male rats of both strains were studied at 8, 16 and 30 weeks of age. The following brain areas were isolated: anterior, medial and posterior hypothalamus, septal area, peri-aqueductal gray (PG) and the remaining brain stem; nucleus tractus solitarius (NTS) and the remaining medulla oblongata. Plasma renin activity (PRA) and plasma and cerebrospinal fluid (CSF) AoC were determined. Renin-like concentration was higher in SHR than in WKY in the anterior hypothalamus, PG and NTS at different stages of hypertension development. AoC was also higher in some areas of the SHR brain during different periods. PRA, plasma and CSF angiotensinogen concentration showed significant differences between both strain of rats during the development of high blood pressure. Present data support the possibility that the central and peripheral renin-angiotensin system may participate in the maintenance of high blood pressure in the SHR animals.</abstract><cop>Basel</cop><cop>Hong Kong</cop><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>2407392</pmid><doi>10.3109/10641969009074720</doi><tpages>19</tpages></addata></record> |
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| identifier | ISSN: 1064-1963 |
| ispartof | Clinical and experimental hypertension (1993), 1990, Vol.A12 (1), p.63-81 |
| issn | 1064-1963 0730-0077 1525-6006 |
| language | eng |
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| source | MEDLINE; Taylor & Francis |
| subjects | Age Age Factors Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensinogen - analysis Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Brain Chemistry Brain localization Cardiology. Vascular system Experimental diseases Hypertension - physiopathology Male Medical sciences Protein Precursors - analysis Rats Rats, Inbred SHR Rats, Inbred WKY Renin - analysis Renin-Angiotensin Renin-Angiotensin System - physiology Spontaneously hypertensive rats (SHR) |
| title | The Renin-Angiotensin System in Different Stages of Spontaneous Hypertension in the Rat (S H R) |
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