Progress in the design of DNA sequence-specific lexitropsins

Progress in the design of DNA sequence-specific lexitropsins

Sequence‐specific polyamides that bind in the minor groove of DNA are attractive candidates for antibiotics, cancer chemotherapeutics, and transcriptional antagonists. This paper reviews the progress of structure‐based design of minor‐groove‐binding polyamides, from the first structure of netropsin...

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Veröffentlicht in:Biopolymers 1997, Vol.44 (4), p.323-334
Hauptverfasser: Walker, Wynn L., Kopka, Mary L., Goodsell, David S.
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - chemistry
Antiviral Agents - chemistry
Base Sequence
Binding Sites
DNA
DNA - chemistry
Drug Design
lexitropsins
minor groove
Models, Molecular
Netropsin - analogs & derivatives
Netropsin - chemistry
Nucleic Acid Conformation
Oligodeoxyribonucleotides
Protein Conformation
rational drug design
sequence-specific polyamides
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Zusammenfassung:Sequence‐specific polyamides that bind in the minor groove of DNA are attractive candidates for antibiotics, cancer chemotherapeutics, and transcriptional antagonists. This paper reviews the progress of structure‐based design of minor‐groove‐binding polyamides, from the first structure of netropsin with DNA, to the effective linked polyamides currently under study. A theory of polyamide specificity is also reviewed, introducing methods to determine the optimal strategies for targeting a given DNA sequence within a genome of competing sequences. © 1998 John Wiley & Sons, Inc. Biopoly 44: 323–334, 1997
ISSN:0006-3525
1097-0282
DOI:10.1002/(SICI)1097-0282(1997)44:4<323::AID-BIP2>3.0.CO;2-0