Effect of a vegetable oil formula rich in linoleic acid on tissue fatty acid accretion in the brain, liver, plasma, and erythrocytes of infant piglets
The effect of feeding sow-milk formula (SMF) or a vegetable-oil infant formula (FF) with minimal n-6 and n-3 long-chain polyenoic fatty acids (LCPs) but high linoleic acid (18:2n-6) and a high ratio of 18:2n-6 to linolenic acid (18:3n-3) on the fatty acids of brain lipid and liver, plasma, and red c...
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| Veröffentlicht in: | The American journal of clinical nutrition 1990-02, Vol.51 (2), p.173-182 |
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| creator | Hrboticky, N MacKinnon, MJ Innis, SM |
| description | The effect of feeding sow-milk formula (SMF) or a vegetable-oil infant formula (FF) with minimal n-6 and n-3 long-chain polyenoic fatty acids (LCPs) but high linoleic acid (18:2n-6) and a high ratio of 18:2n-6 to linolenic acid (18:3n-3) on the fatty acids of brain lipid and liver, plasma, and red cell phospholipids was studied in piglets fed from birth for 5, 10, 15, or 25 d. Compared with SMF, FF reduced the concentrations of 18:1 and n-3 LCPs, especially 22:6n-3, in all tissues and increased 22:4n-6 in brain, liver, plasma, and red cell phosphatidylethanolamine. FF also increased 22:5n-6 in brain lipid, liver, and plasma but not in red cell phospholipids. Thus, changes in tissues capable of in situ desaturation were not completely reflected in the red cell phospholipids. The increased liver and brain n-6 LCP accretion in the FF piglets may suggest competent desaturation and possible inhibition of n-3 desaturation and/or acylation by dietary n-6 fatty acids. |
| doi_str_mv | 10.1093/ajcn/51.2.173 |
| format | Article |
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Compared with SMF, FF reduced the concentrations of 18:1 and n-3 LCPs, especially 22:6n-3, in all tissues and increased 22:4n-6 in brain, liver, plasma, and red cell phosphatidylethanolamine. FF also increased 22:5n-6 in brain lipid, liver, and plasma but not in red cell phospholipids. Thus, changes in tissues capable of in situ desaturation were not completely reflected in the red cell phospholipids. 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Compared with SMF, FF reduced the concentrations of 18:1 and n-3 LCPs, especially 22:6n-3, in all tissues and increased 22:4n-6 in brain, liver, plasma, and red cell phosphatidylethanolamine. FF also increased 22:5n-6 in brain lipid, liver, and plasma but not in red cell phospholipids. Thus, changes in tissues capable of in situ desaturation were not completely reflected in the red cell phospholipids. The increased liver and brain n-6 LCP accretion in the FF piglets may suggest competent desaturation and possible inhibition of n-3 desaturation and/or acylation by dietary n-6 fatty acids.</description><subject>Animals</subject><subject>Body Weight</subject><subject>Brain Chemistry - drug effects</subject><subject>Dietary Fats - pharmacology</subject><subject>Erythrocytes - analysis</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids - metabolism</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Food</subject><subject>Linoleic Acids - pharmacology</subject><subject>Liver - analysis</subject><subject>Male</subject><subject>Organ Size</subject><subject>Phospholipids - analysis</subject><subject>Plant Oils - pharmacology</subject><subject>Swine</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1rGzEQhkVpSd20xx4LOvXkdaTVfmiPJaQfEOilPQvtaBQraCVX0hr8R_p7I2PTW08D8z7zDjMvIR8523E2iTv9DOGu57t2x0fximz4JGQjWja-JhvGWNtMfOjfknc5PzPG204ON-SmFawfmdiQvw_WIhQaLdX0iE9Y9OyRRuepjWlZvabJwZ66QL0L0aMDqsEZGgMtLucVqdWlnC5NDZCwuKpVvuyRzkm7sK2jR0xbevA6L3pLdTAU06nsU4RTwXze7oLVodCDe_JY8nvyxmqf8cO13pLfXx9-3X9vHn9--3H_5bEBIYbS9NxYaXj9g4HedFbiLFo00PX1Zi16kHKabA9Wtp0YB8lnCzM3bGDaCs46cUs-X3wPKf5ZMRe1uAzovQ4Y16zGaRByGmUFmwsIKeac0KpDcotOJ8WZOuegzjmonqtW1Rwq_-lqvM4Lmn_09fFVHy861uuODpPK4DAAGpdqHspE9x_nF0OQmNE</recordid><startdate>19900201</startdate><enddate>19900201</enddate><creator>Hrboticky, N</creator><creator>MacKinnon, MJ</creator><creator>Innis, SM</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900201</creationdate><title>Effect of a vegetable oil formula rich in linoleic acid on tissue fatty acid accretion in the brain, liver, plasma, and erythrocytes of infant piglets</title><author>Hrboticky, N ; MacKinnon, MJ ; Innis, SM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-51df8d1109dc5d4f8eb32edc45165a35c8899f5cf82437681bfcb1d060af31043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Body Weight</topic><topic>Brain Chemistry - drug effects</topic><topic>Dietary Fats - pharmacology</topic><topic>Erythrocytes - analysis</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids - metabolism</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Food</topic><topic>Linoleic Acids - pharmacology</topic><topic>Liver - analysis</topic><topic>Male</topic><topic>Organ Size</topic><topic>Phospholipids - analysis</topic><topic>Plant Oils - pharmacology</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hrboticky, N</creatorcontrib><creatorcontrib>MacKinnon, MJ</creatorcontrib><creatorcontrib>Innis, SM</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hrboticky, N</au><au>MacKinnon, MJ</au><au>Innis, SM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a vegetable oil formula rich in linoleic acid on tissue fatty acid accretion in the brain, liver, plasma, and erythrocytes of infant piglets</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1990-02-01</date><risdate>1990</risdate><volume>51</volume><issue>2</issue><spage>173</spage><epage>182</epage><pages>173-182</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>The effect of feeding sow-milk formula (SMF) or a vegetable-oil infant formula (FF) with minimal n-6 and n-3 long-chain polyenoic fatty acids (LCPs) but high linoleic acid (18:2n-6) and a high ratio of 18:2n-6 to linolenic acid (18:3n-3) on the fatty acids of brain lipid and liver, plasma, and red cell phospholipids was studied in piglets fed from birth for 5, 10, 15, or 25 d. 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| ispartof | The American journal of clinical nutrition, 1990-02, Vol.51 (2), p.173-182 |
| issn | 0002-9165 1938-3207 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Body Weight Brain Chemistry - drug effects Dietary Fats - pharmacology Erythrocytes - analysis Fatty Acids - blood Fatty Acids - metabolism Humans Infant Infant Food Linoleic Acids - pharmacology Liver - analysis Male Organ Size Phospholipids - analysis Plant Oils - pharmacology Swine |
| title | Effect of a vegetable oil formula rich in linoleic acid on tissue fatty acid accretion in the brain, liver, plasma, and erythrocytes of infant piglets |
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