Induction of transforming growth factor beta-1 in cervical intraepithelial neoplasia in vivo after treatment with beta-carotene
Transforming growth factor (TGF) beta1 is a potent growth inhibitor of epithelial cells. Loss of responsiveness to TGF-beta1 and/or loss of TGF-beta1 itself may be important in the progression of cervical intraepithelial neoplasia to invasive cervical cancer. Retinoids have antiproliferative effects...
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| Veröffentlicht in: | Clinical cancer research 1997-02, Vol.3 (2), p.157-160 |
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| creator | J T Comerci, Jr C D Runowicz A L Fields S L Romney P R Palan A S Kadish G L Goldberg |
| description | Transforming growth factor (TGF) beta1 is a potent growth inhibitor of epithelial cells. Loss of responsiveness to TGF-beta1
and/or loss of TGF-beta1 itself may be important in the progression of cervical intraepithelial neoplasia to invasive cervical
cancer. Retinoids have antiproliferative effects on epithelial cells and have been used as chemopreventive and chemotherapeutic
agents for several human cancers. There is evidence that retinoids exert their effects by promoting the induction of TGF-beta.
The aim of this study was to determine whether the expression of TGF-beta1 was altered in patients enrolled in a clinical
trial designed to test the therapeutic efficacy of beta-carotene, a carotenoid metabolized to retinol, in cervical intraepithelial
neoplasia. Using an immunohistochemical technique, tissues were stained with two types of antisera that react with the intracellular
and extracellular forms of TGF-beta1. Matched cervical biopsies taken from 10 patients before and after treatment with beta-carotene
were immunostained simultaneously to allow direct comparison of relative staining intensity. A significant increase in intracellular
TGF-beta1 immunoreactivity was noted in cervical epithelial cells in patients with cervical intraepithelial neoplasia after
treatment with beta-carotene (P = 0.003). These results demonstrate regulation of a TGF-beta isoform in vivo in humans in
response to beta-carotene administered as a chemopreventive agent. |
| format | Article |
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and/or loss of TGF-beta1 itself may be important in the progression of cervical intraepithelial neoplasia to invasive cervical
cancer. Retinoids have antiproliferative effects on epithelial cells and have been used as chemopreventive and chemotherapeutic
agents for several human cancers. There is evidence that retinoids exert their effects by promoting the induction of TGF-beta.
The aim of this study was to determine whether the expression of TGF-beta1 was altered in patients enrolled in a clinical
trial designed to test the therapeutic efficacy of beta-carotene, a carotenoid metabolized to retinol, in cervical intraepithelial
neoplasia. Using an immunohistochemical technique, tissues were stained with two types of antisera that react with the intracellular
and extracellular forms of TGF-beta1. Matched cervical biopsies taken from 10 patients before and after treatment with beta-carotene
were immunostained simultaneously to allow direct comparison of relative staining intensity. A significant increase in intracellular
TGF-beta1 immunoreactivity was noted in cervical epithelial cells in patients with cervical intraepithelial neoplasia after
treatment with beta-carotene (P = 0.003). These results demonstrate regulation of a TGF-beta isoform in vivo in humans in
response to beta-carotene administered as a chemopreventive agent.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 9815667</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>beta Carotene - therapeutic use ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Cervical Intraepithelial Neoplasia - metabolism ; Cervical Intraepithelial Neoplasia - pathology ; Cervical Intraepithelial Neoplasia - prevention & control ; Chemoprevention ; Female ; Foods and miscellaneous ; Humans ; Immunohistochemistry ; Medical sciences ; Transforming Growth Factor beta - analysis ; Transforming Growth Factor beta - biosynthesis ; Tumors ; Uterine Cervical Neoplasms - metabolism ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - prevention & control</subject><ispartof>Clinical cancer research, 1997-02, Vol.3 (2), p.157-160</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2781677$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9815667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>J T Comerci, Jr</creatorcontrib><creatorcontrib>C D Runowicz</creatorcontrib><creatorcontrib>A L Fields</creatorcontrib><creatorcontrib>S L Romney</creatorcontrib><creatorcontrib>P R Palan</creatorcontrib><creatorcontrib>A S Kadish</creatorcontrib><creatorcontrib>G L Goldberg</creatorcontrib><title>Induction of transforming growth factor beta-1 in cervical intraepithelial neoplasia in vivo after treatment with beta-carotene</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Transforming growth factor (TGF) beta1 is a potent growth inhibitor of epithelial cells. Loss of responsiveness to TGF-beta1
and/or loss of TGF-beta1 itself may be important in the progression of cervical intraepithelial neoplasia to invasive cervical
cancer. Retinoids have antiproliferative effects on epithelial cells and have been used as chemopreventive and chemotherapeutic
agents for several human cancers. There is evidence that retinoids exert their effects by promoting the induction of TGF-beta.
The aim of this study was to determine whether the expression of TGF-beta1 was altered in patients enrolled in a clinical
trial designed to test the therapeutic efficacy of beta-carotene, a carotenoid metabolized to retinol, in cervical intraepithelial
neoplasia. Using an immunohistochemical technique, tissues were stained with two types of antisera that react with the intracellular
and extracellular forms of TGF-beta1. Matched cervical biopsies taken from 10 patients before and after treatment with beta-carotene
were immunostained simultaneously to allow direct comparison of relative staining intensity. A significant increase in intracellular
TGF-beta1 immunoreactivity was noted in cervical epithelial cells in patients with cervical intraepithelial neoplasia after
treatment with beta-carotene (P = 0.003). These results demonstrate regulation of a TGF-beta isoform in vivo in humans in
response to beta-carotene administered as a chemopreventive agent.</description><subject>beta Carotene - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Cervical Intraepithelial Neoplasia - metabolism</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervical Intraepithelial Neoplasia - prevention & control</subject><subject>Chemoprevention</subject><subject>Female</subject><subject>Foods and miscellaneous</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Transforming Growth Factor beta - analysis</subject><subject>Transforming Growth Factor beta - biosynthesis</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - prevention & control</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoso67r6E4QcxFshaZqPHmXxY0HwoueSppNtpG1qku7iyb9ull30MMwM8_DOzHuWLQljIqcFZ-epxkLmuKTFZXYVwifGpCS4XGSLShLGuVhmP5uxnXW0bkTOoOjVGIzzgx23aOvdPnbIKB2dRw1ElRNkR6TB76xWfaoTD5ONHfQ29SO4qVfBqgO1szuHlIngkyqoOMAY0T6xRyWtvIswwnV2YVQf4OaUV9nH0-P7-iV_fXverB9e867gPOYV5yVrZXG4vxGmaoAYzRgUAhoq08ecVbRsKmwkbbSStMC8wk0pq1ZhWhq6yu6PupN3XzOEWA82aOh7la6eQy0qTlPIBN6ewLkZoK0nbwflv-uTY2l-d5qrkEwwyTFtwx9WCEm4EP_7Orvt9tZDrRMI3kMA5XVX07qoCRP0F9UdhHw</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>J T Comerci, Jr</creator><creator>C D Runowicz</creator><creator>A L Fields</creator><creator>S L Romney</creator><creator>P R Palan</creator><creator>A S Kadish</creator><creator>G L Goldberg</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19970201</creationdate><title>Induction of transforming growth factor beta-1 in cervical intraepithelial neoplasia in vivo after treatment with beta-carotene</title><author>J T Comerci, Jr ; C D Runowicz ; A L Fields ; S L Romney ; P R Palan ; A S Kadish ; G L Goldberg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-96645d821410b7f9be1fc55e27eb3855765934b90f83bca8320690b489da034f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>beta Carotene - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Cervical Intraepithelial Neoplasia - metabolism</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervical Intraepithelial Neoplasia - prevention & control</topic><topic>Chemoprevention</topic><topic>Female</topic><topic>Foods and miscellaneous</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Transforming Growth Factor beta - analysis</topic><topic>Transforming Growth Factor beta - biosynthesis</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>J T Comerci, Jr</creatorcontrib><creatorcontrib>C D Runowicz</creatorcontrib><creatorcontrib>A L Fields</creatorcontrib><creatorcontrib>S L Romney</creatorcontrib><creatorcontrib>P R Palan</creatorcontrib><creatorcontrib>A S Kadish</creatorcontrib><creatorcontrib>G L Goldberg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>J T Comerci, Jr</au><au>C D Runowicz</au><au>A L Fields</au><au>S L Romney</au><au>P R Palan</au><au>A S Kadish</au><au>G L Goldberg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of transforming growth factor beta-1 in cervical intraepithelial neoplasia in vivo after treatment with beta-carotene</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>1997-02-01</date><risdate>1997</risdate><volume>3</volume><issue>2</issue><spage>157</spage><epage>160</epage><pages>157-160</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Transforming growth factor (TGF) beta1 is a potent growth inhibitor of epithelial cells. Loss of responsiveness to TGF-beta1
and/or loss of TGF-beta1 itself may be important in the progression of cervical intraepithelial neoplasia to invasive cervical
cancer. Retinoids have antiproliferative effects on epithelial cells and have been used as chemopreventive and chemotherapeutic
agents for several human cancers. There is evidence that retinoids exert their effects by promoting the induction of TGF-beta.
The aim of this study was to determine whether the expression of TGF-beta1 was altered in patients enrolled in a clinical
trial designed to test the therapeutic efficacy of beta-carotene, a carotenoid metabolized to retinol, in cervical intraepithelial
neoplasia. Using an immunohistochemical technique, tissues were stained with two types of antisera that react with the intracellular
and extracellular forms of TGF-beta1. Matched cervical biopsies taken from 10 patients before and after treatment with beta-carotene
were immunostained simultaneously to allow direct comparison of relative staining intensity. A significant increase in intracellular
TGF-beta1 immunoreactivity was noted in cervical epithelial cells in patients with cervical intraepithelial neoplasia after
treatment with beta-carotene (P = 0.003). These results demonstrate regulation of a TGF-beta isoform in vivo in humans in
response to beta-carotene administered as a chemopreventive agent.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>9815667</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Clinical cancer research, 1997-02, Vol.3 (2), p.157-160 |
| issn | 1078-0432 1557-3265 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | beta Carotene - therapeutic use Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cervical Intraepithelial Neoplasia - metabolism Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - prevention & control Chemoprevention Female Foods and miscellaneous Humans Immunohistochemistry Medical sciences Transforming Growth Factor beta - analysis Transforming Growth Factor beta - biosynthesis Tumors Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - prevention & control |
| title | Induction of transforming growth factor beta-1 in cervical intraepithelial neoplasia in vivo after treatment with beta-carotene |
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