Experience with univentricular support in mortally ill cardiac transplant candidates
Between July 1987 and March 1989, 11 patients underwent left ventricular support with the Novacor left ventricular assist system irrespective of apparent degree of right ventricular failure. The first 2 patients died of multisystem organ failure while on support. All the remaining patients survived...
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| Veröffentlicht in: | The Annals of thoracic surgery 1990-02, Vol.49 (2), p.261-272 |
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| container_title | The Annals of thoracic surgery |
| container_volume | 49 |
| creator | Kormos, Robert L. Borovetz, Harvey S. Gasior, Thomas Antaki, James F. Armitage, John M. Pristas, John M. Hardesty, Robert L. Griffith, Bartley P. |
| description | Between July 1987 and March 1989, 11 patients underwent left ventricular support with the Novacor left ventricular assist system irrespective of apparent degree of right ventricular failure. The first 2 patients died of multisystem organ failure while on support. All the remaining patients survived the support period, and actuarial survival after transplantation was 100% at 6 months and 89% at 1 year. In no patient did bacterial infection develop during support or after transplantation. Right ventricular ejection fraction before implantation of the left ventricular assist system was lower than 15% in 6 of 6 patients, yet it increased twofold during left ventricular support. The need for excessive inotropic support (2 patients) or temporary (four days) mechanical right ventricular support (2 patients) while on the left ventricular support system appeared to be related to elevated pulmonary vascular resistance during support in association with large preimplantation ventricular volumes. It appears that even patients with compromised right ventricular performance can be supported long term with a left ventricular assist device. Patients with elevated pulmonary vascular resistance may require temporary right ventricular support. |
| doi_str_mv | 10.1016/0003-4975(90)90148-Y |
| format | Article |
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The first 2 patients died of multisystem organ failure while on support. All the remaining patients survived the support period, and actuarial survival after transplantation was 100% at 6 months and 89% at 1 year. In no patient did bacterial infection develop during support or after transplantation. Right ventricular ejection fraction before implantation of the left ventricular assist system was lower than 15% in 6 of 6 patients, yet it increased twofold during left ventricular support. The need for excessive inotropic support (2 patients) or temporary (four days) mechanical right ventricular support (2 patients) while on the left ventricular support system appeared to be related to elevated pulmonary vascular resistance during support in association with large preimplantation ventricular volumes. It appears that even patients with compromised right ventricular performance can be supported long term with a left ventricular assist device. Patients with elevated pulmonary vascular resistance may require temporary right ventricular support.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/0003-4975(90)90148-Y</identifier><identifier>PMID: 2306148</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Assisted Circulation - adverse effects ; Assisted Circulation - methods ; Biomechanical Phenomena ; Blood Pressure ; Cardiac Volume ; Critical Care ; Equipment Design ; Female ; Heart Diseases - surgery ; Heart Transplantation ; Heart-Assist Devices - adverse effects ; Heparin - therapeutic use ; Humans ; Male ; Middle Aged ; Preoperative Care ; Prospective Studies ; Stroke Volume</subject><ispartof>The Annals of thoracic surgery, 1990-02, Vol.49 (2), p.261-272</ispartof><rights>1990 The Society of Thoracic Surgeons</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-63a5c56b88c0f693ca44a91859f087c01c4850b199e4a951732436847f1d07e73</citedby><cites>FETCH-LOGICAL-c438t-63a5c56b88c0f693ca44a91859f087c01c4850b199e4a951732436847f1d07e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2306148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kormos, Robert L.</creatorcontrib><creatorcontrib>Borovetz, Harvey S.</creatorcontrib><creatorcontrib>Gasior, Thomas</creatorcontrib><creatorcontrib>Antaki, James F.</creatorcontrib><creatorcontrib>Armitage, John M.</creatorcontrib><creatorcontrib>Pristas, John M.</creatorcontrib><creatorcontrib>Hardesty, Robert L.</creatorcontrib><creatorcontrib>Griffith, Bartley P.</creatorcontrib><title>Experience with univentricular support in mortally ill cardiac transplant candidates</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Between July 1987 and March 1989, 11 patients underwent left ventricular support with the Novacor left ventricular assist system irrespective of apparent degree of right ventricular failure. The first 2 patients died of multisystem organ failure while on support. All the remaining patients survived the support period, and actuarial survival after transplantation was 100% at 6 months and 89% at 1 year. In no patient did bacterial infection develop during support or after transplantation. Right ventricular ejection fraction before implantation of the left ventricular assist system was lower than 15% in 6 of 6 patients, yet it increased twofold during left ventricular support. The need for excessive inotropic support (2 patients) or temporary (four days) mechanical right ventricular support (2 patients) while on the left ventricular support system appeared to be related to elevated pulmonary vascular resistance during support in association with large preimplantation ventricular volumes. It appears that even patients with compromised right ventricular performance can be supported long term with a left ventricular assist device. Patients with elevated pulmonary vascular resistance may require temporary right ventricular support.</description><subject>Adult</subject><subject>Assisted Circulation - adverse effects</subject><subject>Assisted Circulation - methods</subject><subject>Biomechanical Phenomena</subject><subject>Blood Pressure</subject><subject>Cardiac Volume</subject><subject>Critical Care</subject><subject>Equipment Design</subject><subject>Female</subject><subject>Heart Diseases - surgery</subject><subject>Heart Transplantation</subject><subject>Heart-Assist Devices - adverse effects</subject><subject>Heparin - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Preoperative Care</subject><subject>Prospective Studies</subject><subject>Stroke Volume</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PAyEQxYnR1Fr9BppwMnpYhQV24WJimvonaeKlHnoilGUjhu6uwFb77WXbxqOnycx7b2B-AFxidIcRLu4RQiSjomQ3At0KhCnPlkdgjBnLsyJn4hiM_yyn4CyEz9TmSR6BUU5QkQJjsJj9dMZb02gDv238gH1jN6aJ3ureKQ9D33Wtj9A2cJ2qcm4LrXNQK19ZpWH0qgmdU01Mo6aylYomnIOTWrlgLg51At6fZovpSzZ_e36dPs4zTQmPWUEU06xYca5RXQiiFaVKYM5EjXipEdaUM7TCQpg0Z7gkOSUFp2WNK1SakkzA9X5v59uv3oQo1zZo49J3TNsHWYqClJwNRro3at-G4E0tO2_Xym8lRnKAKQdSciAlBZI7mHKZYleH_f1qbaq_0IFe0h_2uklHbqzxMugdysp6o6OsWvv_A79maYPy</recordid><startdate>19900201</startdate><enddate>19900201</enddate><creator>Kormos, Robert L.</creator><creator>Borovetz, Harvey S.</creator><creator>Gasior, Thomas</creator><creator>Antaki, James F.</creator><creator>Armitage, John M.</creator><creator>Pristas, John M.</creator><creator>Hardesty, Robert L.</creator><creator>Griffith, Bartley P.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900201</creationdate><title>Experience with univentricular support in mortally ill cardiac transplant candidates</title><author>Kormos, Robert L. ; Borovetz, Harvey S. ; Gasior, Thomas ; Antaki, James F. ; Armitage, John M. ; Pristas, John M. ; Hardesty, Robert L. ; Griffith, Bartley P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-63a5c56b88c0f693ca44a91859f087c01c4850b199e4a951732436847f1d07e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Assisted Circulation - adverse effects</topic><topic>Assisted Circulation - methods</topic><topic>Biomechanical Phenomena</topic><topic>Blood Pressure</topic><topic>Cardiac Volume</topic><topic>Critical Care</topic><topic>Equipment Design</topic><topic>Female</topic><topic>Heart Diseases - surgery</topic><topic>Heart Transplantation</topic><topic>Heart-Assist Devices - adverse effects</topic><topic>Heparin - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Preoperative Care</topic><topic>Prospective Studies</topic><topic>Stroke Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kormos, Robert L.</creatorcontrib><creatorcontrib>Borovetz, Harvey S.</creatorcontrib><creatorcontrib>Gasior, Thomas</creatorcontrib><creatorcontrib>Antaki, James F.</creatorcontrib><creatorcontrib>Armitage, John M.</creatorcontrib><creatorcontrib>Pristas, John M.</creatorcontrib><creatorcontrib>Hardesty, Robert L.</creatorcontrib><creatorcontrib>Griffith, Bartley P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kormos, Robert L.</au><au>Borovetz, Harvey S.</au><au>Gasior, Thomas</au><au>Antaki, James F.</au><au>Armitage, John M.</au><au>Pristas, John M.</au><au>Hardesty, Robert L.</au><au>Griffith, Bartley P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experience with univentricular support in mortally ill cardiac transplant candidates</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1990-02-01</date><risdate>1990</risdate><volume>49</volume><issue>2</issue><spage>261</spage><epage>272</epage><pages>261-272</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Between July 1987 and March 1989, 11 patients underwent left ventricular support with the Novacor left ventricular assist system irrespective of apparent degree of right ventricular failure. 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Patients with elevated pulmonary vascular resistance may require temporary right ventricular support.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>2306148</pmid><doi>10.1016/0003-4975(90)90148-Y</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Annals of thoracic surgery, 1990-02, Vol.49 (2), p.261-272 |
| issn | 0003-4975 1552-6259 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Assisted Circulation - adverse effects Assisted Circulation - methods Biomechanical Phenomena Blood Pressure Cardiac Volume Critical Care Equipment Design Female Heart Diseases - surgery Heart Transplantation Heart-Assist Devices - adverse effects Heparin - therapeutic use Humans Male Middle Aged Preoperative Care Prospective Studies Stroke Volume |
| title | Experience with univentricular support in mortally ill cardiac transplant candidates |
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