Oxygen dependence of oxidative stress: Rate of nadph supply for maintaining the GSH pool during hypoxia

NADPH supply for oxidized glutathione (GSSG) reduction was studied in hepatocytes under different steady-state O 2 concentrations with controlled infusions of diamide, a thiol oxidant. When bis-chloronitrosourea (BCNU) was used to inhibit GSSG reductase, the rate of GSH depletion approximated the ra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 1990-02, Vol.39 (4), p.729-736
Hauptverfasser:	Tribble, Diane L., Jones, Dean P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carmustine - pharmacology Cell metabolism, cell oxidation Cell physiology Citrates - pharmacology Citric Acid Diamide - metabolism Fundamental and applied biological sciences. Psychology Glucose - pharmacology glutathione Glutathione - metabolism Glutathione Reductase - antagonists & inhibitors hypoxia Hypoxia - metabolism Kinetics Liver - drug effects Liver - metabolism Male Molecular and cellular biology NADP - metabolism NADPH Oxidation-Reduction Oxygen - pharmacology Rats Sulfhydryl Compounds - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!