Successful treatment of severe refractory idiopathic thrombocytopenic purpura with liposomal doxorubicin
Idiopathic thrombocytopenic purpura (ITP) is refractory to initial treatment (steroids and splenectomy) in 25 to 30% of patients. These patients have a significant risk of fatal hemorrhage. Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded...
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| Veröffentlicht in: | American Journal of Hematology 1998-01, Vol.57 (1), p.85-86 |
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| container_title | American Journal of Hematology |
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| creator | Cosgriff, Thomas M. Black, Marcus L. Stein, William |
| description | Idiopathic thrombocytopenic purpura (ITP) is refractory to initial treatment (steroids and splenectomy) in 25 to 30% of patients. These patients have a significant risk of fatal hemorrhage. Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded to treatment with liposomal doxorubicin with a return of platelet counts to normal. The drug is easily administered and was well tolerated. Use of this drug in refractory ITP merits further study. Am. J. Hematol. 57:85–86, 1998. © 1998 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-8652(199801)57:1<85::AID-AJH16>3.0.CO;2-8 |
| format | Article |
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These patients have a significant risk of fatal hemorrhage. Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded to treatment with liposomal doxorubicin with a return of platelet counts to normal. The drug is easily administered and was well tolerated. Use of this drug in refractory ITP merits further study. Am. J. 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These patients have a significant risk of fatal hemorrhage. Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded to treatment with liposomal doxorubicin with a return of platelet counts to normal. The drug is easily administered and was well tolerated. Use of this drug in refractory ITP merits further study. Am. J. Hematol. 57:85–86, 1998. © 1998 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Doxorubicin - administration & dosage</subject><subject>Female</subject><subject>Humans</subject><subject>ITP</subject><subject>liposomal doxorubicin</subject><subject>Liposomes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Purpura, Thrombocytopenic, Idiopathic - drug therapy</subject><subject>refractory</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UV2L1DAUDaKs4-pPEPogsvvQMR9tmoyLMNSPHVmYh12fL0maMpG2qUnrOv_ejDPMiyIEEu499-TccxC6IXhJMKbvru439eaaYMlzwUt6RaQUmFyX1YrciHK1Wm8-5uuvt4R_YEu8rLfvaS6eoMV54ClaYMZJemP5HL2I8TvGhBQCX6ALWVAmaLFAu_vZGBtjO3fZFKyaejtMmW-zaH_aYLNg26DM5MM-c43zo5p2zmTTLvhee7Of_GiHVBjnkI7KHt20yzo3-uh71WWN_-XDrJ1xw0v0rFVdtK9O9yX69vnTQ32b322_bOr1XW6YxDxvGq0NUdxWheCsaVqtZFVxWRZlqURVNU1RaEKUsC3VurJat0LKtBdTklPM2CV6e-Qdg_8x2zhB76KxXacG6-cIleSsTCMJ-HAEmuBjTHvCGFyvwh4IhkMAAIcA4OAnHPyEYwBQVkBAlAApAPgTADDAUG-Bgki0r0__z7q3zZn05Hjqvzn1VTSqS-4OxsUzjBLKeIXZ2Z5H19n9X9L-r-xfwo4F9hurVLAB</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Cosgriff, Thomas M.</creator><creator>Black, Marcus L.</creator><creator>Stein, William</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>Successful treatment of severe refractory idiopathic thrombocytopenic purpura with liposomal doxorubicin</title><author>Cosgriff, Thomas M. ; Black, Marcus L. ; Stein, William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3906-ddbbc1a6e74863ddfba977695455a877dd44b11a8ef2bb7ebbf8990113a962033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Doxorubicin - administration & dosage</topic><topic>Female</topic><topic>Humans</topic><topic>ITP</topic><topic>liposomal doxorubicin</topic><topic>Liposomes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Purpura, Thrombocytopenic, Idiopathic - drug therapy</topic><topic>refractory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cosgriff, Thomas M.</creatorcontrib><creatorcontrib>Black, Marcus L.</creatorcontrib><creatorcontrib>Stein, William</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American Journal of Hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cosgriff, Thomas M.</au><au>Black, Marcus L.</au><au>Stein, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of severe refractory idiopathic thrombocytopenic purpura with liposomal doxorubicin</atitle><jtitle>American Journal of Hematology</jtitle><addtitle>Am J Hematol</addtitle><date>1998-01</date><risdate>1998</risdate><volume>57</volume><issue>1</issue><spage>85</spage><epage>86</epage><pages>85-86</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Idiopathic thrombocytopenic purpura (ITP) is refractory to initial treatment (steroids and splenectomy) in 25 to 30% of patients. These patients have a significant risk of fatal hemorrhage. Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded to treatment with liposomal doxorubicin with a return of platelet counts to normal. The drug is easily administered and was well tolerated. Use of this drug in refractory ITP merits further study. Am. J. Hematol. 57:85–86, 1998. © 1998 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9423824</pmid><doi>10.1002/(SICI)1096-8652(199801)57:1<85::AID-AJH16>3.0.CO;2-8</doi><tpages>2</tpages></addata></record> |
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| ispartof | American Journal of Hematology, 1998-01, Vol.57 (1), p.85-86 |
| issn | 0361-8609 1096-8652 |
| language | eng |
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| source | MEDLINE; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals |
| subjects | Adult Aged Antibiotics, Antineoplastic - administration & dosage Antineoplastic agents Biological and medical sciences Chemotherapy Doxorubicin - administration & dosage Female Humans ITP liposomal doxorubicin Liposomes Male Medical sciences Pharmacology. Drug treatments Purpura, Thrombocytopenic, Idiopathic - drug therapy refractory |
| title | Successful treatment of severe refractory idiopathic thrombocytopenic purpura with liposomal doxorubicin |
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