Reduced Aggressiveness and Low Testosterone Levels in Autoimmune MRL-lpr Males
Šakić, B., L. Gurunlian, S. D. Denberg. Reduced aggressiveness and low testosterone levels in autoimmune MRL-lpr males. PHYSIOL BEHAV 63(2) 305–309, 1998.—Autoimmune, lupus-prone MRL-lpr mice float excessively in the forced swim test, explore novel objects and places less, and show blunted responsiv...
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| Veröffentlicht in: | Physiology & behavior 1998-01, Vol.63 (2), p.305-309 |
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| creator | Šakić, Boris Gurunlian, Leonard Denburg, Susan D |
| description | Šakić, B., L. Gurunlian, S. D. Denberg.
Reduced aggressiveness and low testosterone levels in autoimmune MRL-lpr males.
PHYSIOL BEHAV 63(2) 305–309, 1998.—Autoimmune, lupus-prone MRL-lpr mice float excessively in the forced swim test, explore novel objects and places less, and show blunted responsiveness to palatable stimuli, which is consistent with the hypothesis that the development of chronic autoimmune disease alters emotional reactivity and/or motivation. The present study measures isolation-induced fighting, a model of “affective” aggression, in lupus-prone MRL-lpr and control MRL +/+ males. When compared with controls, autoimmune MRL-lpr mice show reduced aggressiveness, as evidenced by fewer fighting contacts, longer attack latency, shorter fighting episodes and shorter duration of fighting. In addition, reduced testosterone levels accompany serological signs of autoimmunity in the MRL-lpr males. The present results support the hypothesis that affective responsiveness is altered in lupus-prone mice and may suggest limbic system dysfunction during chronic autoimmune/inflammatory disease. The question of whether immune activation alters behavior by a direct effect on the nervous system, or also via the endocrine system, requires further study. |
| doi_str_mv | 10.1016/S0031-9384(97)00422-8 |
| format | Article |
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Reduced aggressiveness and low testosterone levels in autoimmune MRL-lpr males.
PHYSIOL BEHAV 63(2) 305–309, 1998.—Autoimmune, lupus-prone MRL-lpr mice float excessively in the forced swim test, explore novel objects and places less, and show blunted responsiveness to palatable stimuli, which is consistent with the hypothesis that the development of chronic autoimmune disease alters emotional reactivity and/or motivation. The present study measures isolation-induced fighting, a model of “affective” aggression, in lupus-prone MRL-lpr and control MRL +/+ males. When compared with controls, autoimmune MRL-lpr mice show reduced aggressiveness, as evidenced by fewer fighting contacts, longer attack latency, shorter fighting episodes and shorter duration of fighting. In addition, reduced testosterone levels accompany serological signs of autoimmunity in the MRL-lpr males. The present results support the hypothesis that affective responsiveness is altered in lupus-prone mice and may suggest limbic system dysfunction during chronic autoimmune/inflammatory disease. The question of whether immune activation alters behavior by a direct effect on the nervous system, or also via the endocrine system, requires further study.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/S0031-9384(97)00422-8</identifier><identifier>PMID: 9423973</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Affective response ; Aggression - physiology ; Aggressiveness ; Animals ; Autoimmunity ; Autoimmunity - physiology ; Behavioral immunology ; Behavioral psychophysiology ; Biological and medical sciences ; Conflict (Psychology) ; Fundamental and applied biological sciences. Psychology ; Hormones and behavior ; Interleukin-6 ; Lupus ; Male ; Mice ; Mice, Inbred MRL lpr ; MRL mice ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Resident-intruder paradigm ; Social Isolation ; Testosterone ; Testosterone - blood</subject><ispartof>Physiology & behavior, 1998-01, Vol.63 (2), p.305-309</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-4c918f527ba6f4ea0c10b604789707f1418f0f4a2ba90018fb3b16bf961bb4f73</citedby><cites>FETCH-LOGICAL-c422t-4c918f527ba6f4ea0c10b604789707f1418f0f4a2ba90018fb3b16bf961bb4f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0031-9384(97)00422-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2074710$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9423973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Šakić, Boris</creatorcontrib><creatorcontrib>Gurunlian, Leonard</creatorcontrib><creatorcontrib>Denburg, Susan D</creatorcontrib><title>Reduced Aggressiveness and Low Testosterone Levels in Autoimmune MRL-lpr Males</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Šakić, B., L. Gurunlian, S. D. Denberg.
Reduced aggressiveness and low testosterone levels in autoimmune MRL-lpr males.
PHYSIOL BEHAV 63(2) 305–309, 1998.—Autoimmune, lupus-prone MRL-lpr mice float excessively in the forced swim test, explore novel objects and places less, and show blunted responsiveness to palatable stimuli, which is consistent with the hypothesis that the development of chronic autoimmune disease alters emotional reactivity and/or motivation. The present study measures isolation-induced fighting, a model of “affective” aggression, in lupus-prone MRL-lpr and control MRL +/+ males. When compared with controls, autoimmune MRL-lpr mice show reduced aggressiveness, as evidenced by fewer fighting contacts, longer attack latency, shorter fighting episodes and shorter duration of fighting. In addition, reduced testosterone levels accompany serological signs of autoimmunity in the MRL-lpr males. The present results support the hypothesis that affective responsiveness is altered in lupus-prone mice and may suggest limbic system dysfunction during chronic autoimmune/inflammatory disease. The question of whether immune activation alters behavior by a direct effect on the nervous system, or also via the endocrine system, requires further study.</description><subject>Affective response</subject><subject>Aggression - physiology</subject><subject>Aggressiveness</subject><subject>Animals</subject><subject>Autoimmunity</subject><subject>Autoimmunity - physiology</subject><subject>Behavioral immunology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Conflict (Psychology)</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and behavior</subject><subject>Interleukin-6</subject><subject>Lupus</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred MRL lpr</subject><subject>MRL mice</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Resident-intruder paradigm</subject><subject>Social Isolation</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVpcN00P8Gwh1LSwzajlbxanYoJbVLYpOA4kJuQtKOgsh-utOuQfx8lNr5Gl0GaZ6SXR4QsKPygQMuLOwBGc8kqfi7FdwBeFHn1gcxpJVi-BPHwkcyPyCfyOcZ_kBbjbEZmkhdMCjYnt2tsJotNtnp8DBij32GfSqb7JquHp2yDcRziiGHoMatxh23MfJ-tpnHwXTelw5t1nbfbkN3oFuMXcuJ0G_HsUE_J_e9fm8vrvP579edyVec2xRxzbiWt3LIQRpeOowZLwZTARSUFCEd56oLjujBaAqSNYYaWxsmSGsOdYKfk2_7ebRj-Tymj6ny02La6x2GKSsiSFSXn74JUFEvKuEzgcg_aMMQY0Klt8J0Oz4qCehWu3oSrV5tKCvUmXFVpbnF4YDIdNsepg-HU_3ro62h164LurY9HrADBBYWE_dxjSTDuPAYVrcc-_YwPaEfVDP6dIC9_I5uR</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Šakić, Boris</creator><creator>Gurunlian, Leonard</creator><creator>Denburg, Susan D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>Reduced Aggressiveness and Low Testosterone Levels in Autoimmune MRL-lpr Males</title><author>Šakić, Boris ; Gurunlian, Leonard ; Denburg, Susan D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-4c918f527ba6f4ea0c10b604789707f1418f0f4a2ba90018fb3b16bf961bb4f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Affective response</topic><topic>Aggression - physiology</topic><topic>Aggressiveness</topic><topic>Animals</topic><topic>Autoimmunity</topic><topic>Autoimmunity - physiology</topic><topic>Behavioral immunology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Conflict (Psychology)</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and behavior</topic><topic>Interleukin-6</topic><topic>Lupus</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred MRL lpr</topic><topic>MRL mice</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Resident-intruder paradigm</topic><topic>Social Isolation</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Šakić, Boris</creatorcontrib><creatorcontrib>Gurunlian, Leonard</creatorcontrib><creatorcontrib>Denburg, Susan D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Šakić, Boris</au><au>Gurunlian, Leonard</au><au>Denburg, Susan D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Aggressiveness and Low Testosterone Levels in Autoimmune MRL-lpr Males</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1998-01</date><risdate>1998</risdate><volume>63</volume><issue>2</issue><spage>305</spage><epage>309</epage><pages>305-309</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Šakić, B., L. Gurunlian, S. D. Denberg.
Reduced aggressiveness and low testosterone levels in autoimmune MRL-lpr males.
PHYSIOL BEHAV 63(2) 305–309, 1998.—Autoimmune, lupus-prone MRL-lpr mice float excessively in the forced swim test, explore novel objects and places less, and show blunted responsiveness to palatable stimuli, which is consistent with the hypothesis that the development of chronic autoimmune disease alters emotional reactivity and/or motivation. The present study measures isolation-induced fighting, a model of “affective” aggression, in lupus-prone MRL-lpr and control MRL +/+ males. When compared with controls, autoimmune MRL-lpr mice show reduced aggressiveness, as evidenced by fewer fighting contacts, longer attack latency, shorter fighting episodes and shorter duration of fighting. In addition, reduced testosterone levels accompany serological signs of autoimmunity in the MRL-lpr males. The present results support the hypothesis that affective responsiveness is altered in lupus-prone mice and may suggest limbic system dysfunction during chronic autoimmune/inflammatory disease. The question of whether immune activation alters behavior by a direct effect on the nervous system, or also via the endocrine system, requires further study.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9423973</pmid><doi>10.1016/S0031-9384(97)00422-8</doi><tpages>5</tpages></addata></record> |
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| subjects | Affective response Aggression - physiology Aggressiveness Animals Autoimmunity Autoimmunity - physiology Behavioral immunology Behavioral psychophysiology Biological and medical sciences Conflict (Psychology) Fundamental and applied biological sciences. Psychology Hormones and behavior Interleukin-6 Lupus Male Mice Mice, Inbred MRL lpr MRL mice Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Resident-intruder paradigm Social Isolation Testosterone Testosterone - blood |
| title | Reduced Aggressiveness and Low Testosterone Levels in Autoimmune MRL-lpr Males |
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