Desensitization of NMDA receptors does not proceed in the presence of kynurenate

The agonist-induced steady-state desensitization of the N- methyl- d-aspartate (NMDA) receptor was investigated by means of whole cell patch and concentration clamp in isolated pyramidal neurons from rat hippocampus. When administered against a background of previously applied agonist, glycine (Gly)...

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Veröffentlicht in:	Neuroscience letters 1990, Vol.108 (1), p.88-92
Hauptverfasser:	Chizhmakov, I.V., Kiskin, N.I., Tsyndrenko, A.Ya, Krishtal, O.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	[formula omitted] receptor Animals Biological and medical sciences Central nervous system Electrophysiology Fundamental and applied biological sciences. Psychology Glycine Glycine - pharmacology Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology In Vitro Techniques Isolated neuron Kynurenate Kynurenic Acid - pharmacology l-Aspartate Membrane Potentials - drug effects Rats Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - drug effects Receptors, Neurotransmitter - physiology Steady-state desensitization Vertebrates: nervous system and sense organs
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