ISOLATED HUMAN BLOOD PLATELETS DISCRIMINATE BETWEEN ANAESTHETIC AND NON-ANAESTHETIC GASES AT HIGH PRESSURES
We have compared the effects of the anaesthetic gases nitrogen and argon on adenosine diphosphate (ADP)-induced human blood platelet aggregation with the effects of the non-anaesthetic gas helium. All three gases showed dose-dependent inhibition of platelet aggregation. For nitrogen and argon there...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1990-01, Vol.64 (1), p.77-84 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | McIVER, D.J.L. FIELDS, N.D. PHILP, R.B. |
| description | We have compared the effects of the anaesthetic gases nitrogen and argon on adenosine diphosphate (ADP)-induced human blood platelet aggregation with the effects of the non-anaesthetic gas helium. All three gases showed dose-dependent inhibition of platelet aggregation. For nitrogen and argon there was a linear relationship between gas pressure and inhibition of aggregation over the range 15–68 atmospheres absolute (atm abs), whereas helium had a threshold for inhibition of approximately 34 atm abs. The inhibition by all gases was reversible after slow decompression. At pressures greater than 55 atm abs, nitrogen produced less inhibition than helium, indicating anaesthetic-pressure antagonism. Whereas pressure alone and the anaesthetic gases inhibited aggregation, the platelet shape change elicited by ADP was resistant to both nitrogen and helium, indicating that ADP binding and the early events in platelet activation were relatively unaffected by these conditions. |
| doi_str_mv | 10.1093/bja/64.1.77 |
| format | Article |
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All three gases showed dose-dependent inhibition of platelet aggregation. For nitrogen and argon there was a linear relationship between gas pressure and inhibition of aggregation over the range 15–68 atmospheres absolute (atm abs), whereas helium had a threshold for inhibition of approximately 34 atm abs. The inhibition by all gases was reversible after slow decompression. At pressures greater than 55 atm abs, nitrogen produced less inhibition than helium, indicating anaesthetic-pressure antagonism. Whereas pressure alone and the anaesthetic gases inhibited aggregation, the platelet shape change elicited by ADP was resistant to both nitrogen and helium, indicating that ADP binding and the early events in platelet activation were relatively unaffected by these conditions.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/64.1.77</identifier><identifier>PMID: 2302380</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adenosine Diphosphate - pharmacology ; Anaesthetics: gases ; Anesthetics - pharmacology ; Anesthetics. Neuromuscular blocking agents ; Argon - pharmacology ; Biological and medical sciences ; Blood: platelet aggregation ; Dose-Response Relationship, Drug ; Female ; Gases - pharmacology ; Helium - pharmacology ; Humans ; Male ; Medical sciences ; Neuropharmacology ; Nitrogen - pharmacology ; Pharmacology. Drug treatments ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - pharmacology ; Pressure ; Theories of anaesthetic action: pressure reversal</subject><ispartof>British journal of anaesthesia : BJA, 1990-01, Vol.64 (1), p.77-84</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-51847d5ff777abaf4f1f9eb44cfb199eaa8c298d6df48ed57daf6ba5e4fe24c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6736487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2302380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McIVER, D.J.L.</creatorcontrib><creatorcontrib>FIELDS, N.D.</creatorcontrib><creatorcontrib>PHILP, R.B.</creatorcontrib><title>ISOLATED HUMAN BLOOD PLATELETS DISCRIMINATE BETWEEN ANAESTHETIC AND NON-ANAESTHETIC GASES AT HIGH PRESSURES</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>We have compared the effects of the anaesthetic gases nitrogen and argon on adenosine diphosphate (ADP)-induced human blood platelet aggregation with the effects of the non-anaesthetic gas helium. All three gases showed dose-dependent inhibition of platelet aggregation. For nitrogen and argon there was a linear relationship between gas pressure and inhibition of aggregation over the range 15–68 atmospheres absolute (atm abs), whereas helium had a threshold for inhibition of approximately 34 atm abs. The inhibition by all gases was reversible after slow decompression. At pressures greater than 55 atm abs, nitrogen produced less inhibition than helium, indicating anaesthetic-pressure antagonism. Whereas pressure alone and the anaesthetic gases inhibited aggregation, the platelet shape change elicited by ADP was resistant to both nitrogen and helium, indicating that ADP binding and the early events in platelet activation were relatively unaffected by these conditions.</description><subject>Adenosine Diphosphate - pharmacology</subject><subject>Anaesthetics: gases</subject><subject>Anesthetics - pharmacology</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Argon - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood: platelet aggregation</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Gases - pharmacology</subject><subject>Helium - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Nitrogen - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Pressure</subject><subject>Theories of anaesthetic action: pressure reversal</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9r2zAUx0VZ6bKup50HOoxehlPJli3r6DpqbObYIXa2souQZQnc5kcnJaP97-uQEHbY5b3H9_vhy-MLwBeMxhix4K59kncRGeMxpRdghAnFXkQp_gBGCCHqIYb9j-CTc08IYeqz8Apc-QHygxiNwHNeV0XS8AnMlrOkhPdFVU3g_CAVvKnhJK_TRT7Ly0GA97z5xXkJkzLhdZPxJk-HewLLqvT-1aZJzWuYNDDLpxmcL3hdL4fxGVwauXL65rSvwfKBN2nmFdU0T5PCUyQgOy_EMaFdaAylVLbSEIMN0y0hyrSYMS1lrHwWd1FnSKy7kHbSRK0MNTHaJyoMrsHtMffFbv_stduJde-UXq3kRm_3TlAW4RizeAC_H0Flt85ZbcSL7dfSvgmMxKFaMVQrIiKwoHSgv55i9-1ad2f21OXgfzv50im5MlZuVO_OWESDiMSHGO-I9W6nX8-2tM8HhIYie_wtHh9-ZLP54qdIBz488nqo7G-vrXCq1xulu95qtRPdtv_vu--ZpZrV</recordid><startdate>199001</startdate><enddate>199001</enddate><creator>McIVER, D.J.L.</creator><creator>FIELDS, N.D.</creator><creator>PHILP, R.B.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199001</creationdate><title>ISOLATED HUMAN BLOOD PLATELETS DISCRIMINATE BETWEEN ANAESTHETIC AND NON-ANAESTHETIC GASES AT HIGH PRESSURES</title><author>McIVER, D.J.L. ; FIELDS, N.D. ; PHILP, R.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-51847d5ff777abaf4f1f9eb44cfb199eaa8c298d6df48ed57daf6ba5e4fe24c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adenosine Diphosphate - pharmacology</topic><topic>Anaesthetics: gases</topic><topic>Anesthetics - pharmacology</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Argon - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood: platelet aggregation</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Gases - pharmacology</topic><topic>Helium - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Nitrogen - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Pressure</topic><topic>Theories of anaesthetic action: pressure reversal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McIVER, D.J.L.</creatorcontrib><creatorcontrib>FIELDS, N.D.</creatorcontrib><creatorcontrib>PHILP, R.B.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McIVER, D.J.L.</au><au>FIELDS, N.D.</au><au>PHILP, R.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ISOLATED HUMAN BLOOD PLATELETS DISCRIMINATE BETWEEN ANAESTHETIC AND NON-ANAESTHETIC GASES AT HIGH PRESSURES</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1990-01</date><risdate>1990</risdate><volume>64</volume><issue>1</issue><spage>77</spage><epage>84</epage><pages>77-84</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>We have compared the effects of the anaesthetic gases nitrogen and argon on adenosine diphosphate (ADP)-induced human blood platelet aggregation with the effects of the non-anaesthetic gas helium. All three gases showed dose-dependent inhibition of platelet aggregation. For nitrogen and argon there was a linear relationship between gas pressure and inhibition of aggregation over the range 15–68 atmospheres absolute (atm abs), whereas helium had a threshold for inhibition of approximately 34 atm abs. The inhibition by all gases was reversible after slow decompression. At pressures greater than 55 atm abs, nitrogen produced less inhibition than helium, indicating anaesthetic-pressure antagonism. Whereas pressure alone and the anaesthetic gases inhibited aggregation, the platelet shape change elicited by ADP was resistant to both nitrogen and helium, indicating that ADP binding and the early events in platelet activation were relatively unaffected by these conditions.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2302380</pmid><doi>10.1093/bja/64.1.77</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of anaesthesia : BJA, 1990-01, Vol.64 (1), p.77-84 |
| issn | 0007-0912 1471-6771 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adenosine Diphosphate - pharmacology Anaesthetics: gases Anesthetics - pharmacology Anesthetics. Neuromuscular blocking agents Argon - pharmacology Biological and medical sciences Blood: platelet aggregation Dose-Response Relationship, Drug Female Gases - pharmacology Helium - pharmacology Humans Male Medical sciences Neuropharmacology Nitrogen - pharmacology Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Pressure Theories of anaesthetic action: pressure reversal |
| title | ISOLATED HUMAN BLOOD PLATELETS DISCRIMINATE BETWEEN ANAESTHETIC AND NON-ANAESTHETIC GASES AT HIGH PRESSURES |
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