Visualization of neurokinin-3 receptor sites in rat brain using the highly selective ligand [ 3H]senktide

The autoradiographic distribution of the neurokinin (NK)-3 receptor sub-type was visualized in the rat brain using [ 3H]senktide, a highly selective ligand. [ 3H]Senktide apparently binds to a single class of high affinity ( K d = 2.8 ± 1.0nM), low capacity ( B max = 31.2 ± 3.0fmol/mg protein) sites...

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Veröffentlicht in:	Brain research 1990, Vol.506 (1), p.175-179
Hauptverfasser:	Dam, Than-Vinh, Escher, Emanuel, Quirion, Re´mi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Binding site Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - metabolism Fundamental and applied biological sciences. Psychology Male Neurokinin Peptide Fragments - metabolism Rats Rats, Inbred Strains Receptor sub-type Receptors, Neurokinin-3 Receptors, Neurotransmitter - metabolism Senktide Substance P - analogs & derivatives Substance P - metabolism Vertebrates: nervous system and sense organs
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