Residual immunity of athymic NCr/sed nude mice and the xenotransplantation of human tumors

This study assessed the residual immunity possessed by NCr/Sed (nu/nu) athymic nude mice and examined strategies to reduce it in order to enhance the transplantability of human tumors for experimentation. Adult (8‐week‐old) female mice had fewer T cells (11%) and more B and NK (asialo‐GM1‐positive [...

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Veröffentlicht in:	International journal of cancer 1990-02, Vol.45 (2), p.325-333
Hauptverfasser:	Silobricic, Vlatko, Zietman, Anthony L., Ramsay, Jonathan R., Suit, Herman D., Sedlacek, Robert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunosuppression Killer Cells, Natural - physiology Macrophages - physiology Male Mice Mice, Nude - immunology Modulation of the immune response (stimulation, suppression) Neoplasm Transplantation T-Lymphocytes - immunology Transplantation, Heterologous Whole-Body Irradiation
Online-Zugang:	Volltext
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