Comparison of the acid stability of azithromycin and erythromycin A

In acidic aqueous media, erythromycin A is rapidly degraded via intramolecular dehydration to form erythromycin-6,9-hemiketal and then anhydroerythromycin, both of which possess little antimicrobial activity. Azithromycin, a new azalide antibiotic, has a methyl-substituted nitrogen in place of the c...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1990, Vol.25 (suppl-A), p.39-47
Hauptverfasser:	Fiese, E. F., Steffen, S. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitriles - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Azithromycin Biological and medical sciences Chromatography, High Pressure Liquid Drug Stability Erythromycin - analogs & derivatives Erythromycin - pharmacokinetics Hydrogen-Ion Concentration Hydrolysis Medical sciences Pharmacology. Drug treatments
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