Gastrointestinal symptoms and delayed gastric emptying in Fabryʼs disease: Response to metoclopramide
SUMMARYThe pathophysiology of gastrointestinal symptoms in patients with Fabryʼs disease is uncertain, despite the demonstration of histological and radiographic abnormalities of the gastrointestinal tract. The aims of this study were to determine if the gastrointestinal symptoms reported by patient...
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| Veröffentlicht in: | Nuclear medicine communications 1998-09, Vol.19 (9), p.887-892 |
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| creator | ARGOFF, C E BARTON, N W BRADY, R O ZIESSMAN, H A |
| description | SUMMARYThe pathophysiology of gastrointestinal symptoms in patients with Fabryʼs disease is uncertain, despite the demonstration of histological and radiographic abnormalities of the gastrointestinal tract. The aims of this study were to determine if the gastrointestinal symptoms reported by patients with Fabryʼs disease are associated with abnormal gastric emptying and, if they are, whether prokinetic drug therapy would be beneficial. Ten patients with Fabryʼs disease had radionuclide gastric emptying studies performed to determine if gastrointestinal symptoms correlated with objective evidence of abnormal gastric emptying. A second study was performed in seven patients who received 5 days of therapy with oral metoclopramide. The mean percent solid gastric emptying for Fabryʼs patients was significantly less than that of a normal control group (40 vs 67%, P < 0.005). Five of seven patients with symptoms had abnormal gastric emptying. Six of seven symptomatic patients reported clinical improvement with metoclopramide. Of four symptomatic patients who had a repeat study after treatment, two showed improved emptying. In conclusion, our results suggest that gastrointestinal symptoms in Fabryʼs disease are frequently associated with delayed gastric emptying and that treatment with metoclopramide produces symptomatic and sometimes functional improvement. |
| doi_str_mv | 10.1097/00006231-199809000-00009 |
| format | Article |
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The aims of this study were to determine if the gastrointestinal symptoms reported by patients with Fabryʼs disease are associated with abnormal gastric emptying and, if they are, whether prokinetic drug therapy would be beneficial. Ten patients with Fabryʼs disease had radionuclide gastric emptying studies performed to determine if gastrointestinal symptoms correlated with objective evidence of abnormal gastric emptying. A second study was performed in seven patients who received 5 days of therapy with oral metoclopramide. The mean percent solid gastric emptying for Fabryʼs patients was significantly less than that of a normal control group (40 vs 67%, P < 0.005). Five of seven patients with symptoms had abnormal gastric emptying. Six of seven symptomatic patients reported clinical improvement with metoclopramide. Of four symptomatic patients who had a repeat study after treatment, two showed improved emptying. In conclusion, our results suggest that gastrointestinal symptoms in Fabryʼs disease are frequently associated with delayed gastric emptying and that treatment with metoclopramide produces symptomatic and sometimes functional improvement.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>DOI: 10.1097/00006231-199809000-00009</identifier><identifier>PMID: 10581595</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Antiemetics - therapeutic use ; Biological and medical sciences ; Child, Preschool ; Digestion. Liver. Biliary tract. Spleen. Pancreas ; Errors of metabolism ; Fabry Disease - complications ; Fabry Disease - physiopathology ; Female ; Gastric Emptying - drug effects ; Gastrointestinal Diseases - diagnostic imaging ; Gastrointestinal Diseases - etiology ; Gastrointestinal Diseases - physiopathology ; Humans ; Indium Radioisotopes - pharmacokinetics ; Investigative techniques, diagnostic techniques (general aspects) ; Lipids (lysosomal enzyme disorders, storage diseases) ; Male ; Medical sciences ; Metabolic diseases ; Metoclopramide - therapeutic use ; Middle Aged ; Radionuclide Imaging ; Radionuclide investigations ; Radiopharmaceuticals - pharmacokinetics ; Technetium Tc 99m Sulfur Colloid - pharmacokinetics</subject><ispartof>Nuclear medicine communications, 1998-09, Vol.19 (9), p.887-892</ispartof><rights>1998 Lippincott Williams & Wilkins, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1591342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10581595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARGOFF, C E</creatorcontrib><creatorcontrib>BARTON, N W</creatorcontrib><creatorcontrib>BRADY, R O</creatorcontrib><creatorcontrib>ZIESSMAN, H A</creatorcontrib><title>Gastrointestinal symptoms and delayed gastric emptying in Fabryʼs disease: Response to metoclopramide</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>SUMMARYThe pathophysiology of gastrointestinal symptoms in patients with Fabryʼs disease is uncertain, despite the demonstration of histological and radiographic abnormalities of the gastrointestinal tract. The aims of this study were to determine if the gastrointestinal symptoms reported by patients with Fabryʼs disease are associated with abnormal gastric emptying and, if they are, whether prokinetic drug therapy would be beneficial. Ten patients with Fabryʼs disease had radionuclide gastric emptying studies performed to determine if gastrointestinal symptoms correlated with objective evidence of abnormal gastric emptying. A second study was performed in seven patients who received 5 days of therapy with oral metoclopramide. The mean percent solid gastric emptying for Fabryʼs patients was significantly less than that of a normal control group (40 vs 67%, P < 0.005). Five of seven patients with symptoms had abnormal gastric emptying. Six of seven symptomatic patients reported clinical improvement with metoclopramide. Of four symptomatic patients who had a repeat study after treatment, two showed improved emptying. In conclusion, our results suggest that gastrointestinal symptoms in Fabryʼs disease are frequently associated with delayed gastric emptying and that treatment with metoclopramide produces symptomatic and sometimes functional improvement.</description><subject>Adult</subject><subject>Antiemetics - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Digestion. Liver. Biliary tract. Spleen. Pancreas</subject><subject>Errors of metabolism</subject><subject>Fabry Disease - complications</subject><subject>Fabry Disease - physiopathology</subject><subject>Female</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastrointestinal Diseases - diagnostic imaging</subject><subject>Gastrointestinal Diseases - etiology</subject><subject>Gastrointestinal Diseases - physiopathology</subject><subject>Humans</subject><subject>Indium Radioisotopes - pharmacokinetics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lipids (lysosomal enzyme disorders, storage diseases)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metoclopramide - therapeutic use</subject><subject>Middle Aged</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Technetium Tc 99m Sulfur Colloid - pharmacokinetics</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAQgC0EokvhFZAPiFsgthMn5oaqtiBVQkJwjib2uDU4cfBkVeXdeAKeCi-7_FyYizXjb2bkz4xxUb8Stele1yW0VKISxvS1KVl1KJkHbCeaTlWtlv1DtqtFoyqllT5jT4i-FKJXunvMzkTd9qI17Y75a6A1pzCvSGuYIXLapmVNE3GYHXcYYUPHbw9UsBzL3RbmWx5mfgVj3n58J-4CIRC-4R-RljQT8jXxCddkY1oyTMHhU_bIQyR8djrP2eery08X76qbD9fvL97eVFZqaSqvdY3So-h604KxXqLrAY2zOErhjVNqBFkLL40cVQ-u9y2ODhpnZautV-fs5XHuktO3fXnSMAWyGCPMmPY0dEYXXUoVsD-CNieijH5Ycpggb4Ooh4Pj4bfj4Y_jXyVTWp-fduzHCd0_jUepBXhxAoAsRJ9htoH-cq0RqpEFa47YfYorZvoa9_eYhzuEuN4N__ti9ROB_pdU</recordid><startdate>199809</startdate><enddate>199809</enddate><creator>ARGOFF, C E</creator><creator>BARTON, N W</creator><creator>BRADY, R O</creator><creator>ZIESSMAN, H A</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199809</creationdate><title>Gastrointestinal symptoms and delayed gastric emptying in Fabryʼs disease: Response to metoclopramide</title><author>ARGOFF, C E ; BARTON, N W ; BRADY, R O ; ZIESSMAN, H A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2629-f660e2fe17895a9cf2ed8ae9dceb21f9d33ba201f292b38ad8f5ebda4dc256cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Antiemetics - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Digestion. Liver. Biliary tract. Spleen. Pancreas</topic><topic>Errors of metabolism</topic><topic>Fabry Disease - complications</topic><topic>Fabry Disease - physiopathology</topic><topic>Female</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastrointestinal Diseases - diagnostic imaging</topic><topic>Gastrointestinal Diseases - etiology</topic><topic>Gastrointestinal Diseases - physiopathology</topic><topic>Humans</topic><topic>Indium Radioisotopes - pharmacokinetics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lipids (lysosomal enzyme disorders, storage diseases)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metoclopramide - therapeutic use</topic><topic>Middle Aged</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Technetium Tc 99m Sulfur Colloid - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARGOFF, C E</creatorcontrib><creatorcontrib>BARTON, N W</creatorcontrib><creatorcontrib>BRADY, R O</creatorcontrib><creatorcontrib>ZIESSMAN, H A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARGOFF, C E</au><au>BARTON, N W</au><au>BRADY, R O</au><au>ZIESSMAN, H A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastrointestinal symptoms and delayed gastric emptying in Fabryʼs disease: Response to metoclopramide</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>1998-09</date><risdate>1998</risdate><volume>19</volume><issue>9</issue><spage>887</spage><epage>892</epage><pages>887-892</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>SUMMARYThe pathophysiology of gastrointestinal symptoms in patients with Fabryʼs disease is uncertain, despite the demonstration of histological and radiographic abnormalities of the gastrointestinal tract. The aims of this study were to determine if the gastrointestinal symptoms reported by patients with Fabryʼs disease are associated with abnormal gastric emptying and, if they are, whether prokinetic drug therapy would be beneficial. Ten patients with Fabryʼs disease had radionuclide gastric emptying studies performed to determine if gastrointestinal symptoms correlated with objective evidence of abnormal gastric emptying. A second study was performed in seven patients who received 5 days of therapy with oral metoclopramide. The mean percent solid gastric emptying for Fabryʼs patients was significantly less than that of a normal control group (40 vs 67%, P < 0.005). Five of seven patients with symptoms had abnormal gastric emptying. Six of seven symptomatic patients reported clinical improvement with metoclopramide. Of four symptomatic patients who had a repeat study after treatment, two showed improved emptying. In conclusion, our results suggest that gastrointestinal symptoms in Fabryʼs disease are frequently associated with delayed gastric emptying and that treatment with metoclopramide produces symptomatic and sometimes functional improvement.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10581595</pmid><doi>10.1097/00006231-199809000-00009</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Antiemetics - therapeutic use Biological and medical sciences Child, Preschool Digestion. Liver. Biliary tract. Spleen. Pancreas Errors of metabolism Fabry Disease - complications Fabry Disease - physiopathology Female Gastric Emptying - drug effects Gastrointestinal Diseases - diagnostic imaging Gastrointestinal Diseases - etiology Gastrointestinal Diseases - physiopathology Humans Indium Radioisotopes - pharmacokinetics Investigative techniques, diagnostic techniques (general aspects) Lipids (lysosomal enzyme disorders, storage diseases) Male Medical sciences Metabolic diseases Metoclopramide - therapeutic use Middle Aged Radionuclide Imaging Radionuclide investigations Radiopharmaceuticals - pharmacokinetics Technetium Tc 99m Sulfur Colloid - pharmacokinetics |
| title | Gastrointestinal symptoms and delayed gastric emptying in Fabryʼs disease: Response to metoclopramide |
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