Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient
A case of non-Hodgkin's lymphoma of T-cell type occurring in a renal transplant recipient is described. This lymphoma was classified as large cell, immunoblastic type and presented as a mediastinal mass, although it was demonstrated to be disseminated at autopsy two weeks later. Lymphoma cells...
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| Veröffentlicht in: | American journal of clinical pathology 1990-02, Vol.93 (2), p.280-285 |
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| container_end_page | 285 |
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| container_issue | 2 |
| container_start_page | 280 |
| container_title | American journal of clinical pathology |
| container_volume | 93 |
| creator | GRIFFITH, R. C SAHA, B. K JANNEY, C. M RATNER, L BRUNT, E. M GAJL-PECZALSKA, K. J HANTO, D. W |
| description | A case of non-Hodgkin's lymphoma of T-cell type occurring in a renal transplant recipient is described. This lymphoma was classified as large cell, immunoblastic type and presented as a mediastinal mass, although it was demonstrated to be disseminated at autopsy two weeks later. Lymphoma cells expressed the immunologic profile of a mature, activated cytotoxic/suppressor T-lymphocyte. T-cell receptor gene rearrangement and karyotypic studies confirmed a clonal T-cell genotype. Molecular studies failed to demonstrate any association with Epstein-Barr virus or human T-cell lymphotropic virus type I or type II. Pathogenesis of lymphomas in this clinical setting is discussed. |
| doi_str_mv | 10.1093/ajcp/93.2.280 |
| format | Article |
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Pathogenesis of lymphomas in this clinical setting is discussed.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/93.2.280</identifier><identifier>PMID: 2301290</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adult ; Biological and medical sciences ; Gene Rearrangement, T-Lymphocyte ; Genotype ; Hematologic and hematopoietic diseases ; Humans ; Immunosuppression ; Kidney Transplantation ; Lymph Nodes - pathology ; Lymphoma, Non-Hodgkin - genetics ; Lymphoma, Non-Hodgkin - pathology ; Male ; Medical sciences ; T-Lymphocytes - pathology</subject><ispartof>American journal of clinical pathology, 1990-02, Vol.93 (2), p.280-285</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-b4f7749e4076c86b19c2146a26b4ff7ee077e1a7ba43dfab1c8a63e4d8fbed03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4427135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2301290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GRIFFITH, R. C</creatorcontrib><creatorcontrib>SAHA, B. K</creatorcontrib><creatorcontrib>JANNEY, C. M</creatorcontrib><creatorcontrib>RATNER, L</creatorcontrib><creatorcontrib>BRUNT, E. M</creatorcontrib><creatorcontrib>GAJL-PECZALSKA, K. J</creatorcontrib><creatorcontrib>HANTO, D. W</creatorcontrib><title>Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>A case of non-Hodgkin's lymphoma of T-cell type occurring in a renal transplant recipient is described. This lymphoma was classified as large cell, immunoblastic type and presented as a mediastinal mass, although it was demonstrated to be disseminated at autopsy two weeks later. Lymphoma cells expressed the immunologic profile of a mature, activated cytotoxic/suppressor T-lymphocyte. T-cell receptor gene rearrangement and karyotypic studies confirmed a clonal T-cell genotype. Molecular studies failed to demonstrate any association with Epstein-Barr virus or human T-cell lymphotropic virus type I or type II. Pathogenesis of lymphomas in this clinical setting is discussed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Gene Rearrangement, T-Lymphocyte</subject><subject>Genotype</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunosuppression</subject><subject>Kidney Transplantation</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>T-Lymphocytes - pathology</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kLtrwzAQh0VpSdO0Y8eChtLNiV6x7LGEPgKBLtnNWT4TBT9UyR7831dpQqY77vfdwX2EPHO25CyXKzgat8rlUixFxm7InOdKJloLcUvmjDGR5FzLe_IQwpExHhk1IzMhY5uzOSm3bTt2fdlAGKyhzdS6Q98C7Wu6Tww2DR0mh9R2FKg5-L6zBppmovZ_LYzOeQwBK-qxgwh76IJroBviwFhnsRseyV0NTcCnS12Q_efHfvOd7H6-tpv3XWIk10NSqlprlaNiOjVZWvLcCK5SEGlMao3ItEYOugQlqxpKbjJIJaoqq0usmFyQt_NZ5_vfEcNQtDacPoAO-zEUOk-ZXossgskZNL4PwWNdOG9b8FPBWXFSWpyUFrGKIuqK_Mvl8Fi2WF3pi8OYv15yCFFOHRUYG66YUkJzuZZ_pw-Bog</recordid><startdate>19900201</startdate><enddate>19900201</enddate><creator>GRIFFITH, R. 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M</creatorcontrib><creatorcontrib>RATNER, L</creatorcontrib><creatorcontrib>BRUNT, E. M</creatorcontrib><creatorcontrib>GAJL-PECZALSKA, K. J</creatorcontrib><creatorcontrib>HANTO, D. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GRIFFITH, R. C</au><au>SAHA, B. K</au><au>JANNEY, C. M</au><au>RATNER, L</au><au>BRUNT, E. M</au><au>GAJL-PECZALSKA, K. J</au><au>HANTO, D. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1990-02-01</date><risdate>1990</risdate><volume>93</volume><issue>2</issue><spage>280</spage><epage>285</epage><pages>280-285</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>A case of non-Hodgkin's lymphoma of T-cell type occurring in a renal transplant recipient is described. This lymphoma was classified as large cell, immunoblastic type and presented as a mediastinal mass, although it was demonstrated to be disseminated at autopsy two weeks later. Lymphoma cells expressed the immunologic profile of a mature, activated cytotoxic/suppressor T-lymphocyte. T-cell receptor gene rearrangement and karyotypic studies confirmed a clonal T-cell genotype. Molecular studies failed to demonstrate any association with Epstein-Barr virus or human T-cell lymphotropic virus type I or type II. Pathogenesis of lymphomas in this clinical setting is discussed.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>2301290</pmid><doi>10.1093/ajcp/93.2.280</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1990-02, Vol.93 (2), p.280-285 |
| issn | 0002-9173 1943-7722 |
| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Adult Biological and medical sciences Gene Rearrangement, T-Lymphocyte Genotype Hematologic and hematopoietic diseases Humans Immunosuppression Kidney Transplantation Lymph Nodes - pathology Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - pathology Male Medical sciences T-Lymphocytes - pathology |
| title | Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient |
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