Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists

A series of 73 dibenzo[a,d]cycloalkenimines were synthesized and evaluated for their ability to displace (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine ([3H]-(+)-10) from its specific binding site on rat cortical membranes. A number of the more active compounds (Ki ranging from 0.0...

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Veröffentlicht in:	Journal of medicinal chemistry 1990-02, Vol.33 (2), p.789-808
Hauptverfasser:	Thompson, Wayne J, Anderson, Paul S, Britcher, Susan F, Lyle, Terry A, Thies, J. Eric, Magill, Catherine A, Varga, Sandor L, Schwering, John E, Lyle, Paulette A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - chemical synthesis Aspartic Acid - analogs & derivatives Aspartic Acid - antagonists & inhibitors Binding, Competitive Cerebral Cortex - metabolism Chemical Phenomena Chemistry Condensed matter: structure, mechanical and thermal properties Drug Design Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Imines - chemical synthesis Imines - pharmacology In Vitro Techniques Ion Channels - drug effects Models, Molecular N-Methylaspartate Organic chemistry Organic compounds Physics Polycyclic Compounds - chemical synthesis Polycyclic Compounds - pharmacology Preparations and properties Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - drug effects Structure of solids and liquids crystallography Structure of specific crystalline solids Thermodynamics
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